This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in brea... See more...

Aliases for SPHK2 Gene

Aliases for SPHK2 Gene

  • Sphingosine Kinase 2 2 3 4 5
  • SPK 2 3 4
  • SK 2 3 4
  • Sphingosine Kinase Type 2 3
  • EC 2.7.1.91 4
  • SPK-2 3
  • SK-2 3
  • SK2 4

External Ids for SPHK2 Gene

Previous GeneCards Identifiers for SPHK2 Gene

  • GC19P049767
  • GC19P049490
  • GC19P053798
  • GC19P053814
  • GC19P049122
  • GC19P045501

Summaries for SPHK2 Gene

Entrez Gene Summary for SPHK2 Gene

  • This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SPHK2 Gene

SPHK2 (Sphingosine Kinase 2) is a Protein Coding gene. Diseases associated with SPHK2 include Alzheimer Disease and Dermatitis, Atopic, 7. Among its related pathways are Immune response Fc epsilon RI pathway and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is SPHK1.

UniProtKB/Swiss-Prot Summary for SPHK2 Gene

  • Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Upregulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity).

Tocris Summary for SPHK2 Gene

  • Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Gene Wiki entry for SPHK2 Gene

Additional gene information for SPHK2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPHK2 Gene

Genomics for SPHK2 Gene

GeneHancer (GH) Regulatory Elements for SPHK2 Gene

Promoters and enhancers for SPHK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPHK2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPHK2

Top Transcription factor binding sites by QIAGEN in the SPHK2 gene promoter:
  • CBF(2)
  • CREB
  • deltaCREB
  • Elk-1
  • NF-Y
  • p53
  • USF-1
  • USF1
  • ZIC2

Genomic Locations for SPHK2 Gene

Genomic Locations for SPHK2 Gene
chr19:48,619,291-48,630,717
(GRCh38/hg38)
Size:
11,427 bases
Orientation:
Plus strand
chr19:49,122,548-49,133,974
(GRCh37/hg19)
Size:
11,427 bases
Orientation:
Plus strand

Genomic View for SPHK2 Gene

Genes around SPHK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPHK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPHK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPHK2 Gene

Proteins for SPHK2 Gene

  • Protein details for SPHK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA0-SPHK2_HUMAN
    Recommended name:
    Sphingosine kinase 2
    Protein Accession:
    Q9NRA0
    Secondary Accessions:
    • A0T4C8
    • B4DU87
    • Q9BRN1
    • Q9H0Q2
    • Q9NWU7

    Protein attributes for SPHK2 Gene

    Size:
    654 amino acids
    Molecular mass:
    69217 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with histone H3 (PubMed:19729656). Interacts with HDAC1, HDAC2, MBD2 and SIN3A (PubMed:19729656). Interacts with EEF1A1; the interaction enhances SPHK2 kinase activity (PubMed:18263879). Interacts with PHB2 (By similarity).

    Alternative splice isoforms for SPHK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPHK2 Gene

Post-translational modifications for SPHK2 Gene

  • Phosphorylated by PKD on Ser-419 and Ser-421 upon PMA treatment. Phosphorylation induces export from the nucleus to the cytoplasm (PubMed:17635916). Phosphorylated by MAPK1 and MAPK2 at Ser-387 and Thr-614, phosphorylation is induced by agonists such as EGF and PMA and increases kinase activity (PubMed:17311928).
  • Cleaved by CASP1 in apoptotic cells. The truncated form is released from cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPHK2 Gene

Domains & Families for SPHK2 Gene

Gene Families for SPHK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SPHK2 Gene

Suggested Antigen Peptide Sequences for SPHK2 Gene

GenScript: Design optimal peptide antigens:
  • Sphingosine kinase 2 (SPHK2_HUMAN)
genes like me logo Genes that share domains with SPHK2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPHK2 Gene

Function for SPHK2 Gene

Molecular function for SPHK2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Upregulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+); Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence={ECO:0000269 PubMed:10751414, ECO:0000269 PubMed:12954646, ECO:0000269 PubMed:19729656};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate; Xref=Rhea:RHEA:35847, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35848; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate; Xref=Rhea:RHEA:15465, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxysphinganine + ATP = 4-hydroxysphinganine 1-phosphate + ADP + H(+); Xref=Rhea:RHEA:33563, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:64124, ChEBI:CHEBI:64795, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sulfatide (PubMed:19168031). Kinase activity is increased by phosphorylation by MAPK2 upon PMA or EGF treatments (PubMed:17311928).

Enzyme Numbers (IUBMB) for SPHK2 Gene

Phenotypes From GWAS Catalog for SPHK2 Gene

Gene Ontology (GO) - Molecular Function for SPHK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0005515 protein binding IPI 11777919
GO:0005524 ATP binding IEA --
GO:0008481 sphinganine kinase activity NAS 10751414
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with SPHK2: view
genes like me logo Genes that share phenotypes with SPHK2: view

Animal Models for SPHK2 Gene

MGI Knock Outs for SPHK2:

Animal Model Products

CRISPR Products

miRNA for SPHK2 Gene

miRTarBase miRNAs that target SPHK2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPHK2

Clone Products

  • Addgene plasmids for SPHK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPHK2 Gene

Localization for SPHK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPHK2 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum. Mitochondrion inner membrane. Note=In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). {ECO:0000269 PubMed:19729656, ECO:0000269 PubMed:20197547, ECO:0000269 PubMed:29615132}.
[Isoform 2]: Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPHK2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
endoplasmic reticulum 4
plasma membrane 2
extracellular 2
cytoskeleton 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPHK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 19729656
GO:0005634 nucleus IDA,IEA 17635916
GO:0005737 cytoplasm IEA,IDA 17635916
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SPHK2: view

Pathways & Interactions for SPHK2 Gene

genes like me logo Genes that share pathways with SPHK2: view

Pathways by source for SPHK2 Gene

SIGNOR curated interactions for SPHK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SPHK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0002374 cytokine secretion involved in immune response ISS --
GO:0003376 sphingosine-1-phosphate receptor signaling pathway IEA --
GO:0006669 sphinganine-1-phosphate biosynthetic process NAS 10751414
GO:0006670 sphingosine metabolic process ISS --
genes like me logo Genes that share ontologies with SPHK2: view

Drugs & Compounds for SPHK2 Gene

(13) Drugs for SPHK2 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Sphingosine Experimental Pharma 0
Idronoxil Investigational Pharma inhibitor Caspase activator, XIAP inhibitor, FLIP suppressor, and TOPO II inhibitor 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
ABC294640 Pharma Sphingosine kinase 2 inhibitor,selective and competitive 0

(4) Additional Compounds for SPHK2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
sphinganine 1-phosphate
  • (2S,3R)-2-amino-3-Hydroxyoctadecyl dihydrogen phosphate
  • Dihydrosphingosine 1-phosphate
  • Dihydrosphingosine-1-phosphate
  • (2S,3R)-2-amino-3-Hydroxyoctadecyl dihydrogen phosphoric acid
  • Sphinganine 1-phosphoric acid
19794-97-9
MP A08
219832-49-2
PF 543 hydrochloride
1706522-79-3

(4) Tocris Compounds for SPHK2 Gene

Compound Action Cas Number
MP A08 Selective ATP competitive SphK1 and 2 inhibitor; cell permeable 219832-49-2
N,N-Dimethylsphingosine Sphingosine kinase inhibitor 119567-63-4
PF 543 hydrochloride Potent and selective SphK1 inhibitor 1706522-79-3
SKI II Selective non-lipid inhibitor of sphingosine kinase 312636-16-1

(4) ApexBio Compounds for SPHK2 Gene

Compound Action Cas Number
ABC294640 Sphingosine kinase 2 inhibitor,selective and competitive 915385-81-8
K145 SphK2 inhibitor 1309444-75-4
K145 hydrochloride 1449240-68-9
SKI II Sphingosine kinase(SK) inhibitor 312636-16-1
genes like me logo Genes that share compounds with SPHK2: view

Drug Products

Transcripts for SPHK2 Gene

mRNA/cDNA for SPHK2 Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPHK2

Clone Products

  • Addgene plasmids for SPHK2

Alternative Splicing Database (ASD) splice patterns (SP) for SPHK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13:
SP14: - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - -
SP20: - - -

ExUns: 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: -
SP7:
SP8: -
SP9: - - -
SP10:
SP11:
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for SPHK2 Gene

GeneLoc Exon Structure for
SPHK2

Expression for SPHK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPHK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPHK2 Gene

This gene is overexpressed in Frontal cortex (27.9), Spinal cord (18.0), and Testis (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPHK2 Gene



Protein tissue co-expression partners for SPHK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPHK2

SOURCE GeneReport for Unigene cluster for SPHK2 Gene:

Hs.528006

mRNA Expression by UniProt/SwissProt for SPHK2 Gene:

Q9NRA0-SPHK2_HUMAN
Tissue specificity: Mainly expressed in adult kidney, liver, and brain (PubMed:10751414). Expressed in cerebral cortex and hippocampus (at protein level) (PubMed:29615132). Isoform 1 is the predominant form expressed in most tissues (PubMed:16103110).

Evidence on tissue expression from TISSUES for SPHK2 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with SPHK2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPHK2 Gene

Orthologs for SPHK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPHK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPHK2 31 30
  • 97.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPHK2 31 30
  • 87.77 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPHK2 31
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPHK2 31 30
  • 85.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sphk2 17 31 30
  • 80.92 (n)
rat
(Rattus norvegicus)
Mammalia Sphk2 30
  • 80.67 (n)
lizard
(Anolis carolinensis)
Reptilia SPHK2 31
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sphk2 30
  • 57.41 (n)
zebrafish
(Danio rerio)
Actinopterygii sphk2 31 30
  • 58.51 (n)
OneToOne
Dr.12967 30
fruit fly
(Drosophila melanogaster)
Insecta Sk1 31 32 30
  • 49.18 (n)
ManyToMany
Sk2 31
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sphk-1 31 30
  • 40.16 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB4 31
  • 19 (a)
ManyToMany
LCB5 31
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
OneToMany
Species where no ortholog for SPHK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPHK2 Gene

ENSEMBL:
Gene Tree for SPHK2 (if available)
TreeFam:
Gene Tree for SPHK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPHK2: view image

Paralogs for SPHK2 Gene

Paralogs for SPHK2 Gene

(2) SIMAP similar genes for SPHK2 Gene using alignment to 7 proteins:

  • SPHK2_HUMAN
  • E7ET12_HUMAN
  • E9PCV4_HUMAN
  • M0QXX5_HUMAN
  • M0QZP3_HUMAN
  • M0R0E9_HUMAN
  • M0R344_HUMAN
genes like me logo Genes that share paralogs with SPHK2: view

Variants for SPHK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPHK2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
709706 Benign: not provided 48,629,324(+) G/T MISSENSE_VARIANT
718292 Benign: not provided 48,629,769(+) C/A MISSENSE_VARIANT
719580 Benign: not provided 48,628,060(+) G/T SYNONYMOUS_VARIANT
723906 Benign: not provided 48,628,948(+) C/T SYNONYMOUS_VARIANT
730358 Benign: not provided 48,626,296(+) G/A MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SPHK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPHK2 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
esv1003432 CNV gain 20482838
nsv9739 CNV gain+loss 18304495

Variation tolerance for SPHK2 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPHK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPHK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPHK2 Gene

Disorders for SPHK2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SPHK2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
dermatitis, atopic, 7
  • atod7
ureteral obstruction
mobitz type ii atrioventricular block
  • mobitz ii atrioventricular block
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search SPHK2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SPHK2_HUMAN
  • Note=In patients with Alzheimer's disease brains, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits. {ECO:0000269 PubMed:29615132}.

Additional Disease Information for SPHK2

genes like me logo Genes that share disorders with SPHK2: view

No data available for Genatlas for SPHK2 Gene

Publications for SPHK2 Gene

  1. A lipid binding domain in sphingosine kinase 2. (PMID: 19168031) Don AS … Rosen H (Biochemical and biophysical research communications 2009) 2 3 4 23 54
  2. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. (PMID: 10751414) Liu H … Spiegel S (The Journal of biological chemistry 2000) 2 3 4 23 54
  3. Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. (PMID: 20197547) Weigert A … Brüne B (Blood 2010) 3 4 23 54
  4. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. (PMID: 19729656) Hait NC … Spiegel S (Science (New York, N.Y.) 2009) 3 4 23 54
  5. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. (PMID: 17311928) Hait NC … Spiegel S (The Journal of biological chemistry 2007) 3 4 23 54

Products for SPHK2 Gene

  • Addgene plasmids for SPHK2

Sources for SPHK2 Gene