Aliases for SPEN Gene
Aliases for SPEN Gene
- Spen Family Transcriptional Repressor 2 3 5
- SMART/HDAC1-Associated Repressor Protein 3 4
- SHARP 3 4
- MINT 3 4
- SPEN Homolog, Transcriptional Regulator (Drosophila) 2
- Spen Homolog, Transcriptional Regulator (Drosophila) 2
- Msx2 Interacting Nuclear Target (MINT) Homolog 3
- Nuclear Receptor Transcription Cofactor 3
External Ids for SPEN Gene
- HGNC: 17575
- Entrez Gene: 23013
- Ensembl: ENSG00000065526
- OMIM: 613484
- UniProtKB: Q96T58
Previous GeneCards Identifiers for SPEN Gene
- GC01P015920
- GC01P016047
- GC01P016174
- GC01P014692
Summaries for SPEN Gene
-
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for SPEN Gene
SPEN (Spen Family Transcriptional Repressor) is a Protein Coding gene. Diseases associated with SPEN include Median Arcuate Ligament Syndrome and Endocervicitis. Among its related pathways are Notch-mediated HES/HEY network and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is RBM15.
UniProtKB/Swiss-Prot for SPEN Gene
-
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPEN Gene
Genomics for SPEN Gene
GeneHancer (GH) Regulatory Elements for SPEN Gene
Promoters and enhancers for SPEN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPEN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SPEN gene promoter:
-
- p53
- MEF-2A
- aMEF-2
- HNF-1A
- HNF-1
- HSF2
- Pax-5
- ZIC2
- Pax-4a
Regulatory Element Products
Genomic Locations for SPEN Gene
Genomic Locations for SPEN Gene
- chr1:15,847,864-15,940,460
- (GRCh38/hg38)
- Size:
- 92,597 bases
- Orientation:
- Plus strand
- chr1:16,174,359-16,266,955
- (GRCh37/hg19)
- Size:
- 92,597 bases
- Orientation:
- Plus strand
Genomic View for SPEN Gene
Genes around SPEN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.21-p36.13 by Entrez Gene
- 1p36.21-p36.13 by HGNC
- 1p36.21 by Ensembl
SPEN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPEN Gene
Proteins for SPEN Gene
-
Protein details for SPEN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96T58-MINT_HUMAN
- Recommended name:
- Msx2-interacting protein
- Protein Accession:
- Q96T58
- Q9H9A8
- Q9NWH5
- Q9UQ01
- Q9Y556
Protein attributes for SPEN Gene
- Size:
- 3664 amino acids
- Molecular mass:
- 402248 Da
- Quaternary structure:
-
- Interacts with MSX2 and HIPK3 (By similarity). Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA. Interacts with Epstein-Barr virus BSFL2/BMLF1.
- SequenceCaution:
-
- Sequence=BAA91405.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14324.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB51072.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SPEN Gene
Post-translational modifications for SPEN Gene
Other Protein References for SPEN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SPEN
-
Abcam antibodies for SPEN
- Invitrogen Antibodies for SPEN (AFLGC-SPEN)
- antibodies-online: Search results for available SPEN related products ranked by validation data
- Search GeneTex for Antibodies for SPEN
-
Biorbyt antibodies for SPEN
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SPEN
- Origene Custom Protein Services for SPEN
- Novus Biologicals proteins for SPEN
- antibodies-online: Search results for available SPEN related products ranked by validation data
- Search GeneTex for Proteins for SPEN
-
Abcam proteins for SPEN
Assay Products
- antibodies-online: Search results for available SPEN related products ranked by validation data
No data available for DME Specific Peptides for SPEN Gene
Domains & Families for SPEN Gene
Gene Families for SPEN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SPEN Gene
Suggested Antigen Peptide Sequences for SPEN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96T58UniProtKB/Swiss-Prot:
MINT_HUMAN :- The RID domain mediates the interaction with nuclear receptors.
- Belongs to the RRM Spen family.
- Domain:
-
- The RID domain mediates the interaction with nuclear receptors.
- The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity.
- Family:
-
- Belongs to the RRM Spen family.
Function for SPEN Gene
Molecular function for SPEN Gene
- UniProtKB/Swiss-Prot Function:
- May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
- UniProtKB/Swiss-Prot Induction:
- By 17-beta-estradiol.
Phenotypes From GWAS Catalog for SPEN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | 16287852 |
| GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding | IDA | 16287852 |
| GO:0003676 | nucleic acid binding | IEA,IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | HDA,IEA | 22658674 |
Phenotypes for SPEN Gene
- MGI mutant phenotypes for SPEN:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for SPEN:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased HIV-1 infection
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased viability with paclitaxel
- Decreased NF-kappaB reporter expression
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPEN
-
CRISPR Products
-
OriGene CRISPR knockouts for SPEN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPEN
- genomics-online: gRNA clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- Applied Biological Materials CRISPR for SPEN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPEN
- GenScript: Design CRISPR guide RNA sequences for SPEN
miRNA for SPEN Gene
- miRTarBase miRNAs that target SPEN
-
- hsa-mir-151a-5p (MIRT019521)
- hsa-mir-877-3p (MIRT037187)
- hsa-mir-23b-5p (MIRT038656)
- hsa-mir-769-5p (MIRT039166)
- hsa-mir-615-3p (MIRT039949)
- hsa-mir-193b-3p (MIRT041415)
- hsa-mir-423-3p (MIRT042502)
- hsa-mir-324-5p (MIRT043099)
- hsa-mir-331-3p (MIRT043465)
- hsa-mir-328-3p (MIRT043756)
- hsa-mir-106b-5p (MIRT044364)
- hsa-mir-320a (MIRT044789)
- hsa-mir-186-5p (MIRT045089)
- hsa-mir-125b-5p (MIRT046031)
- hsa-mir-196a-5p (MIRT048159)
- hsa-mir-92a-3p (MIRT049048)
- hsa-mir-16-5p (MIRT051293)
- hsa-mir-18a-5p (MIRT738300)
- hsa-mir-18b-5p (MIRT738304)
- hsa-mir-214-3p (MIRT739004)
- hsa-mir-3619-5p (MIRT741728)
- hsa-mir-4722-5p (MIRT747627)
- hsa-mir-4735-3p (MIRT747985)
- hsa-mir-4768-3p (MIRT748636)
- hsa-mir-6165 (MIRT752521)
- hsa-mir-761 (MIRT759479)
- hsa-mir-885-3p (MIRT760394)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPEN
- Browse OriGene Inhibitory RNA Products For SPEN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPEN
- genomics-online: shRNA clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPEN
- Applied Biological Materials Clones for SPEN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPEN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPEN Gene
Localization for SPEN Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPEN Gene
- Nucleus. Note=Associates with chromatin.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| plasma membrane | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0017053 | transcriptional repressor complex | IDA | 16287852 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for SPEN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Notch signaling pathway (KEGG) | ||
| 2 | Notch-mediated HES/HEY network | ||
Pathways by source for SPEN Gene
3 BioSystems pathways for SPEN Gene
1 R&D Systems pathway for SPEN Gene
Interacting Proteins for SPEN Gene
Selected Interacting proteins:
Q96T58-MINT_HUMAN
ENSP00000364912
for SPEN Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for SPEN
SIGNOR curated interactions for SPEN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 16287852 |
| GO:0000398 | mRNA splicing, via spliceosome | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007219 | Notch signaling pathway | IEA | -- |
Transcripts for SPEN Gene
mRNA/cDNA for SPEN Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (290) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000375759 12232 bps (uc001axk.2)
- ENST00000471538 1404 bps (uc057cpi.1)
- ENST00000438066 1733 bps (uc057cpj.1)
- ENST00000442985 891 bps (uc057cpk.1)
- ENST00000487496 543 bps (uc057cpl.1)
Unigene Clusters for SPEN Gene
- Spen homolog, transcriptional regulator (Drosophila):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SPEN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPEN
- genomics-online: gRNA clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- Applied Biological Materials CRISPR for SPEN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPEN
- GenScript: Design CRISPR guide RNA sequences for SPEN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPEN
- Browse OriGene Inhibitory RNA Products For SPEN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPEN
- genomics-online: shRNA clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPEN
- Applied Biological Materials Clones for SPEN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for SPEN Gene
This gene is overexpressed in Urinary Bladder (30.7), Gallbladder (10.7), and Cervix (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPEN Gene
NURSA nuclear receptor signaling pathways regulating expression of SPEN Gene:
SPENSOURCE GeneReport for Unigene cluster for SPEN Gene:
Hs.744843mRNA Expression by UniProt/SwissProt for SPEN Gene:
Q96T58-MINT_HUMAN
Tissue specificity:
Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin.
Evidence on tissue expression from TISSUES for SPEN Gene
- Nervous system(4.6)
- Liver(4.5)
- Blood(2.4)
- Heart(2.3)
- Intestine(2.3)
- Lung(2.2)
- Skin(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for SPEN
- genomics-online: primer clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPEN Gene
Orthologs for SPEN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPEN 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SPEN 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SPEN 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPEN 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Spen 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC690911 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SPEN 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SPEN 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SPEN 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | spen 34 |
|
OneToMany | |
| SPEN (2 of 2) 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | spen 34 |
|
OneToOne |
- Species where no ortholog for SPEN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SPEN Gene
- ENSEMBL:
- Gene Tree for SPEN (if available)
- TreeFam:
- Gene Tree for SPEN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPEN: view image
Paralogs for SPEN Gene
Variants for SPEN Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869312174 | uncertain-significance, Ductal breast carcinoma | 15,933,237(+) | CAGAAAACAACCCGATCA/CA | coding_sequence_variant, frameshift | |
| VAR_035483 | A breast cancer sample | p.Asp990His | |||
| VAR_035484 | A breast cancer sample | p.Arg1488Ile | |||
| rs374383017 | uncertain-significance, not specified | 15,935,971(+) | CCCCC/CCCCCC/CCCCCCCCCCCCCC/CCCCCCCCCCCTCCCCC | coding_sequence_variant, frameshift, inframe_insertion | |
| rs769360962 | benign, not specified | 15,935,976(+) | A/C/G | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv37n100 | CNV | gain | 25217958 |
| dgv38n100 | CNV | gain | 25217958 |
| esv22591 | CNV | gain | 19812545 |
| esv2665696 | CNV | deletion | 23128226 |
| esv2668319 | CNV | deletion | 23128226 |
| esv2744352 | CNV | deletion | 23290073 |
| esv2764241 | CNV | loss | 21179565 |
| esv3585322 | CNV | loss | 21293372 |
| nsv1011969 | CNV | gain+loss | 25217958 |
| nsv1012917 | CNV | loss | 25217958 |
| nsv1133814 | CNV | deletion | 24896259 |
| nsv3409 | CNV | deletion | 18451855 |
| nsv478397 | CNV | novel sequence insertion | 20440878 |
| nsv508936 | CNV | insertion | 20534489 |
| nsv829559 | CNV | loss | 20364138 |
| nsv833647 | CNV | loss | 17160897 |
| nsv954843 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
0.428% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.96;
79.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPEN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPEN Gene
Disorders for SPEN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| median arcuate ligament syndrome |
|
|
| endocervicitis |
|
|
| lymphoid interstitial pneumonia |
|
|
| acneiform dermatitis |
|
|
| pancreatic cystadenoma |
|
|
Search SPEN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPEN
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SPEN Gene
Publications for SPEN Gene
- Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (PMID: 11331609) Shi Y … Evans RM (Genes & development 2001) 2 3 4 22 58
- Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PMID: 16129689) Hiriart E … Manet E (The Journal of biological chemistry 2005) 3 4 22 58
- A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. (PMID: 12897056) Ariyoshi M … Schwabe JW (Genes & development 2003) 3 4 22 58
- The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. (PMID: 11867749) Shi Y … Evans RM (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 22 58
- Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. (PMID: 17234755) Feng Y … Fearon ER (Cancer research 2007) 3 22 58
Products for SPEN Gene
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SPEN
- Novus Biologicals proteins for SPEN
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SPEN
- Abcam proteins for SPEN
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SPEN (AFLGC-SPEN)
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPEN
- antibodies-online: Search results for available SPEN related products ranked by validation data
- antibodies-online: Search results for available SPEN related products ranked by validation data
- antibodies-online: Search results for available SPEN related products ranked by validation data
- Search GeneTex for Antibodies for SPEN
- Search GeneTex for Proteins for SPEN
- Horizon Cell Lines for SPEN
- genomics-online: cdna clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- orf clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- genomics-online: gRNA clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- genomics-online: primer clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- genomics-online: shRNA clones - Search results for 37 available SPEN gene related products
- Overview of 37 available SPEN gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPEN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPEN
- GeneCopoeia miRNA 3'UTR Target clone products for SPEN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPEN
- Biorbyt antibodies for SPEN
Sources for SPEN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt