Aliases for SPEM2 Gene

Aliases for SPEM2 Gene

  • SPEM Family Member 2 2 3 5
  • Uncharacterized Protein SPEM2 3 4
  • C17orf74 3 4
  • Chromosome 17 Open Reading Frame 74 2
  • Uncharacterized Protein C17orf74 3

External Ids for SPEM2 Gene

Previous HGNC Symbols for SPEM2 Gene

  • C17orf74

Previous GeneCards Identifiers for SPEM2 Gene

  • GC17P007838
  • GC17P007873
  • GC17P007924
  • GC17P007697
  • GC17P007726
  • GC17P007757
  • GC17P007802

Summaries for SPEM2 Gene

GeneCards Summary for SPEM2 Gene

SPEM2 (SPEM Family Member 2) is a Protein Coding gene. Diseases associated with SPEM2 include Scarlet Fever.

Additional gene information for SPEM2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPEM2 Gene

Genomics for SPEM2 Gene

GeneHancer (GH) Regulatory Elements for SPEM2 Gene

Promoters and enhancers for SPEM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007425 Promoter 0.3 EPDnew 500.7 +0.7 716 0.1 SPEM2 TMEM102 ENSG00000262880 L13712-011
GH17J007712 Enhancer 1.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 29.2 +286.8 286820 3 EP300 CTCF ZIC2 RFX1 ZNF341 EZH2 MYNN KLF9 SP2 MXI1 SPEM1 TMEM95 SPEM2 YBX2 DLG4 EFNB3 SLC35G6 CNTROB ELP5 piR-32214-278
GH17J007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 +56.0 55986 13.1 EP300 RXRA HNRNPK FOXK2 ZBTB40 ZNF217 ZSCAN5C TCF12 MYC NRF1 POLR2A ZBTB4 SLC35G6 KIAA0753 DVL2 PFAS ENSG00000265749 SNORD10 SNORA48 KCTD11
GH17J007401 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -20.3 -20320 5.7 ZNF217 TCF12 SIN3A POLR2G SP1 PHF8 FOS ZNF639 ZBTB5 ZIC2 NLGN2 TMEM256 TMEM256-PLSCR3 lnc-NLGN2-1 CHRNB1 SPEM2 ACAP1 TMEM102 ENSG00000224647 NEURL4
GH17J007454 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +31.1 31101 2 ZBTB40 ZNF217 SP1 PHF8 SIX5 POLR2A SAP30 KLF7 MYC CTBP1 CHRNB1 FGF11 SPEM2 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 PLSCR3 ACAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPEM2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPEM2

Genomic Locations for SPEM2 Gene

Genomic Locations for SPEM2 Gene
chr17:7,424,881-7,427,568
(GRCh38/hg38)
Size:
2,688 bases
Orientation:
Plus strand
chr17:7,328,934-7,330,887
(GRCh37/hg19)
Size:
1,954 bases
Orientation:
Plus strand

Genomic View for SPEM2 Gene

Genes around SPEM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPEM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPEM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPEM2 Gene

Proteins for SPEM2 Gene

  • Protein details for SPEM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P670-SPEM2_HUMAN
    Recommended name:
    Uncharacterized protein SPEM2
    Protein Accession:
    Q0P670

    Protein attributes for SPEM2 Gene

    Size:
    501 amino acids
    Molecular mass:
    57131 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPEM2 Gene

Post-translational modifications for SPEM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPEM2 Gene

No data available for DME Specific Peptides for SPEM2 Gene

Domains & Families for SPEM2 Gene

Gene Families for SPEM2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPEM2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SPEM2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPEM2 Gene

Function for SPEM2 Gene

Phenotypes From GWAS Catalog for SPEM2 Gene

genes like me logo Genes that share phenotypes with SPEM2: view

miRNA for SPEM2 Gene

miRTarBase miRNAs that target SPEM2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPEM2 Gene

Localization for SPEM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPEM2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPEM2 gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for SPEM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPEM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPEM2 Gene

Pathways & Interactions for SPEM2 Gene

PathCards logo

SuperPathways for SPEM2 Gene

No Data Available

Interacting Proteins for SPEM2 Gene

;

Gene Ontology (GO) - Biological Process for SPEM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPEM2 Gene

Drugs & Compounds for SPEM2 Gene

No Compound Related Data Available

Transcripts for SPEM2 Gene

mRNA/cDNA for SPEM2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPEM2 Gene

No ASD Table

Relevant External Links for SPEM2 Gene

GeneLoc Exon Structure for
SPEM2

Expression for SPEM2 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPEM2 Gene

Orthologs for SPEM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPEM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf74 30
  • 97.92 (n)
C17orf74 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H17orf74 30
  • 76.42 (n)
C17orf74 31
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC497938 30
  • 72.85 (n)
mouse
(Mus musculus)
Mammalia 4933402P03Rik 31 30
  • 72.79 (n)
OneToOne
Spem2 17
Species where no ortholog for SPEM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPEM2 Gene

ENSEMBL:
Gene Tree for SPEM2 (if available)
TreeFam:
Gene Tree for SPEM2 (if available)

Paralogs for SPEM2 Gene

No data available for Paralogs for SPEM2 Gene

Variants for SPEM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPEM2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs13290 - p.Ser108Ala
rs3892554 - p.Gln376Arg

Additional dbSNP identifiers (rs#s) for SPEM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPEM2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv3639869 CNV loss 21293372
nsv457659 CNV loss 19166990
nsv470575 CNV loss 18288195
nsv523672 CNV loss 19592680
nsv526176 CNV gain 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for SPEM2 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPEM2 Gene

Human Gene Mutation Database (HGMD)
SPEM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPEM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPEM2 Gene

Disorders for SPEM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPEM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
scarlet fever
  • scarlatina
- elite association - COSMIC cancer census association via MalaCards
Search SPEM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPEM2

genes like me logo Genes that share disorders with SPEM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPEM2 Gene

Publications for SPEM2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for SPEM2 Gene

Sources for SPEM2 Gene