Aliases for SPEGNB Gene

Aliases for SPEGNB Gene

  • SPEG Neighbor 2 3 5
  • SPEG Neighbor Protein 3 4
  • SPEGNB 5

External Ids for SPEGNB Gene

Previous GeneCards Identifiers for SPEGNB Gene

  • GC02P219435

Summaries for SPEGNB Gene

GeneCards Summary for SPEGNB Gene

SPEGNB (SPEG Neighbor) is a Protein Coding gene. An important paralog of this gene is OBSCN.

Additional gene information for SPEGNB Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPEGNB Gene

Genomics for SPEGNB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPEGNB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J219495 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.6 1642 5.5 IKZF1 MYC SIX5 ZNF580 ZNF592 ZMYM3 KLF9 POLR2A BRCA1 NFIC GMPPA ENSG00000268603 HSALNG0022385 SPEGNB CNOT9 NHEJ1 USP37 ZNF142 STK36 RNF25
GH02J219492 Enhancer 0.6 Ensembl ENCODE 0.7 -3.5 -3465 0.5 RAD21 EGR1 CTCF ZNF143 ENSG00000286143 ENSG00000268603 SPEGNB ASIC4-AS1 SPEG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPEGNB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPEGNB

Genomic Locations for SPEGNB Gene

Latest Assembly
chr2:219,496,125-219,498,287
(GRCh38/hg38)
Size:
2,163 bases
Orientation:
Plus strand

Previous Assembly
chr2:220,361,077-220,363,009
(GRCh37/hg19 by Entrez Gene)
Size:
1,933 bases
Orientation:
Plus strand

Genomic View for SPEGNB Gene

Genes around SPEGNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPEGNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPEGNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPEGNB Gene

Proteins for SPEGNB Gene

  • Protein details for SPEGNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A087WV53-SPEGN_HUMAN
    Recommended name:
    SPEG neighbor protein
    Protein Accession:
    A0A087WV53

    Protein attributes for SPEGNB Gene

    Size:
    238 amino acids
    Molecular mass:
    26075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPEGNB Gene

Post-translational modifications for SPEGNB Gene

No Post-translational modifications

Other Protein References for SPEGNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPEGNB Gene

Domains & Families for SPEGNB Gene

genes like me logo Genes that share domains with SPEGNB: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPEGNB Gene

Function for SPEGNB Gene

Phenotypes From GWAS Catalog for SPEGNB Gene

Gene Ontology (GO) - Molecular Function for SPEGNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SPEGNB: view

Phenotypes for SPEGNB Gene

genes like me logo Genes that share phenotypes with SPEGNB: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPEGNB Gene

Localization for SPEGNB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPEGNB Gene

Pathways & Interactions for SPEGNB Gene

PathCards logo

SuperPathways for SPEGNB Gene

No Data Available

Interacting Proteins for SPEGNB Gene

Gene Ontology (GO) - Biological Process for SPEGNB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPEGNB Gene

Drugs & Compounds for SPEGNB Gene

No Compound Related Data Available

Transcripts for SPEGNB Gene

mRNA/cDNA for SPEGNB Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPEGNB

Alternative Splicing Database (ASD) splice patterns (SP) for SPEGNB Gene

No ASD Table

Relevant External Links for SPEGNB Gene

GeneLoc Exon Structure for
SPEGNB

Expression for SPEGNB Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPEGNB Gene

Orthologs for SPEGNB Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPEGNB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC101058538 29
  • 99.28 (n)
Dog
(Canis familiaris)
Mammalia LOC102157227 29
  • 94.27 (n)
Species where no ortholog for SPEGNB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPEGNB Gene

ENSEMBL:
Gene Tree for SPEGNB (if available)
TreeFam:
Gene Tree for SPEGNB (if available)
Alliance of Genome Resources:
Additional Orthologs for SPEGNB

Paralogs for SPEGNB Gene

Paralogs for SPEGNB Gene

genes like me logo Genes that share paralogs with SPEGNB: view

Variants for SPEGNB Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPEGNB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPEGNB Gene

Variant ID Type Subtype PubMed ID
nsv520958 CNV loss 19592680
nsv584502 CNV gain 21841781

Additional Variant Information for SPEGNB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPEGNB
Leiden Open Variation Database (LOVD)
SPEGNB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SPEGNB Gene

Disorders for SPEGNB Gene

No disorders were found for SPEGNB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SPEGNB Gene

Publications for SPEGNB Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

No data available for Mastermind for SPEGNB Gene

Products for SPEGNB Gene

Sources for SPEGNB Gene