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SPECC1L-ADORA2A Gene(RNA Gene)

SPECC1L-ADORA2A Readthrough (NMD Candidate)

GCID:
GC22P024391
GIFtS:
15
Genes Participants
UDN Logo

Aliases for SPECC1L-ADORA2A Gene

Subcategory (RNA class) for SPECC1L-ADORA2A Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for SPECC1L-ADORA2A Gene

  • SPECC1L-ADORA2A Readthrough (NMD Candidate) 2 3 5

External Ids for SPECC1L-ADORA2A Gene

Previous GeneCards Identifiers for SPECC1L-ADORA2A Gene

  • GC22U900941
  • GC22P024740
  • GC22P024271
  • GC22P024296
  • GC22P024313
  • GC22P024328
  • GC22P024340
  • GC22P024364
  • GC22P024386

Summaries for SPECC1L-ADORA2A Gene

Entrez Gene Summary for SPECC1L-ADORA2A Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) genes on chromosome 22. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to produce a protein product. [provided by RefSeq, Jun 2013]

GeneCards Summary for SPECC1L-ADORA2A Gene

SPECC1L-ADORA2A (SPECC1L-ADORA2A Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and enzyme binding. An important paralog of this gene is SPECC1L.

Additional gene information for SPECC1L-ADORA2A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPECC1L-ADORA2A Gene

Genomics for SPECC1L-ADORA2A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SPECC1L-ADORA2A Gene

Promoters and enhancers for SPECC1L-ADORA2A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I024270 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 644 2.5 HDGF FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLR2B ZNF213 SPECC1L RPS10P29 SPECC1L-ADORA2A POM121L9P GGTLC4P LOC105372960
GH22I024425 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.1 +161.1 161141 13.9 HDGF PKNOX1 SMAD1 YY1 GLIS2 ZNF207 ZNF143 ATF7 RUNX3 RXRA ADORA2A PIR51261 SPECC1L-ADORA2A POM121L9P UPB1 ADORA2A-AS1 SPECC1L ENSG00000232545 SMARCB1 ZNF70
GH22I024423 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.1 +153.3 153275 1 RB1 KLF17 ZNF76 RAD21 GLIS2 ZNF143 SMARCA5 REST ZEB2 ZNF592 SPECC1L-ADORA2A UPB1 SPECC1L POM121L9P ADORA2A PIR51261
GH22I024284 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 0.4 +14.1 14121 1.2 HDAC1 BCOR MEIS2 PKNOX1 USF1 JUN FEZF1 BATF IRF4 FOSL1 SPECC1L BCRP1 POM121L9P GGTLC4P SPECC1L-ADORA2A LOC105372960
GH22I024274 Enhancer 0.6 Ensembl 0.8 +4.3 4284 0.6 CTCF NR2F1 FEZF1 DPF2 GLIS1 ZNF341 MYNN IKZF1 SPI1 ADORA2A-AS1 UPB1 SPECC1L SPECC1L-ADORA2A LOC105372960
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPECC1L-ADORA2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPECC1L-ADORA2A Gene

Genomic Locations for SPECC1L-ADORA2A Gene
chr22:24,270,817-24,442,360
(GRCh38/hg38)
Size:
171,544 bases
Orientation:
Plus strand
chr22:24,666,866-24,838,324
(GRCh37/hg19)

Genomic View for SPECC1L-ADORA2A Gene

Genes around SPECC1L-ADORA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPECC1L-ADORA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPECC1L-ADORA2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPECC1L-ADORA2A Gene

Proteins for SPECC1L-ADORA2A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SPECC1L-ADORA2A Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WAN1
    Recommended name:
    SPECC1L-ADORA2A readthrough (NMD candidate)
    Protein Accession:
    F8WAN1

    Protein attributes for SPECC1L-ADORA2A Gene

    Size:
    911 amino acids
    Molecular mass:
    101514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPECC1L-ADORA2A Gene

Post-translational modifications for SPECC1L-ADORA2A Gene

No Post-translational modifications

Other Protein References for SPECC1L-ADORA2A Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SPECC1L-ADORA2A Gene

Domains & Families for SPECC1L-ADORA2A Gene

Protein Domains for SPECC1L-ADORA2A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPECC1L-ADORA2A: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPECC1L-ADORA2A Gene

Function for SPECC1L-ADORA2A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPECC1L-ADORA2A Gene

Localization for SPECC1L-ADORA2A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPECC1L-ADORA2A Gene

Pathways & Interactions for SPECC1L-ADORA2A Gene

SuperPathways for SPECC1L-ADORA2A Gene

PathCards logo More details on SuperPathways for SPECC1L-ADORA2A
No Data Available

Interacting Proteins for SPECC1L-ADORA2A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351480%0d%0a9606.ENSP00000392718%0d%0a9606.ENSP00000387176%0d%0a9606.ENSP00000350052%0d%0a9606.ENSP00000439189%0d%0a9606.ENSP00000264202%0d%0a
Selected Interacting proteins: ENSP00000351480 for SPECC1L-ADORA2A Gene via STRING

Gene Ontology (GO) - Biological Process for SPECC1L-ADORA2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPECC1L-ADORA2A Gene

Drugs & Compounds for SPECC1L-ADORA2A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SPECC1L-ADORA2A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SPECC1L-ADORA2A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPECC1L-ADORA2A Gene

No ASD Table

Relevant External Links for SPECC1L-ADORA2A Gene

GeneLoc Exon Structure for
SPECC1L-ADORA2A
ECgene alternative splicing isoforms for
SPECC1L-ADORA2A

Expression for SPECC1L-ADORA2A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPECC1L-ADORA2A Gene

mRNA expression in normal human tissues for SPECC1L-ADORA2A Gene
mRNA expression by GTEx for SPECC1L-ADORA2A Gene
genes like me logo Genes that share expression patterns with SPECC1L-ADORA2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPECC1L-ADORA2A Gene

Orthologs for SPECC1L-ADORA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SPECC1L-ADORA2A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia SPECC1L 34
  • 78 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Specc1l 34
  • 75 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia -- 34
  • 73 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 67 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 51 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves SPECC1L 34
  • 70 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 47 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii specc1la 34
  • 54 (a)
 ManyToMany
specc1lb 34
  • 50 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG13366 34
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.3677 34
  • 22 (a)
 OneToMany
Species where no ortholog for SPECC1L-ADORA2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPECC1L-ADORA2A Gene

ENSEMBL:
Gene Tree for SPECC1L-ADORA2A (if available)
TreeFam:
Gene Tree for SPECC1L-ADORA2A (if available)

Paralogs for SPECC1L-ADORA2A Gene

Paralogs for SPECC1L-ADORA2A Gene

(7) SIMAP similar genes for SPECC1L-ADORA2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPECC1L-ADORA2A: view

Variants for SPECC1L-ADORA2A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SPECC1L-ADORA2A Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs193920978 uncertain-significance, Malignant tumor of prostate 24,321,444(+) G/A/T non_coding_transcript_variant
rs2298383 drug-response, caffeine response - Toxicity/ADR 24,429,543(+) C/A/T intron_variant
rs387907108 pathogenic, Oculomaxillofacial dysostosis 24,322,224(+) A/C non_coding_transcript_variant
rs786201030 pathogenic, Opitz G/BBB syndrome 24,322,169(+) A/C non_coding_transcript_variant
rs786201031 pathogenic, Opitz G/BBB syndrome 24,412,690(+) G/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPECC1L-ADORA2A Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv24290 CNV gain 19812545
esv2724041 CNV deletion 23290073
esv2724068 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893463 CNV gain 25118596
esv996036 CNV deletion 20482838
nsv1055830 CNV gain 25217958
nsv1057819 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv588744 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv834158 CNV gain 17160897
nsv834160 CNV gain 17160897
nsv953060 CNV duplication 24416366
nsv953061 CNV deletion 24416366
nsv964609 CNV duplication 23825009
nsv964610 CNV duplication 23825009
nsv966093 CNV duplication 23825009
nsv979658 CNV duplication 23825009
nsv9883 CNV gain+loss 18304495
nsv9884 CNV gain+loss 18304495

Additional Variant Information for SPECC1L-ADORA2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPECC1L-ADORA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPECC1L-ADORA2A Gene

Disorders for SPECC1L-ADORA2A Gene

Additional Disease Information for SPECC1L-ADORA2A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPECC1L-ADORA2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPECC1L-ADORA2A Gene

Publications for SPECC1L-ADORA2A Gene

  1. Evidence for transcript networks composed of chimeric RNAs in human cells. (PMID: 22238572) Djebali S … Gingeras TR (PloS one 2012) 3 58

Products for SPECC1L-ADORA2A Gene

Sources for SPECC1L-ADORA2A Gene

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