Aliases for SPECC1L Gene
Aliases for SPECC1L Gene
External Ids for SPECC1L Gene
- HGNC: 29022
- Entrez Gene: 23384
- Ensembl: ENSG00000100014
- OMIM: 614140
- UniProtKB: Q69YQ0
Previous HGNC Symbols for SPECC1L Gene
- CYTSA
Previous GeneCards Identifiers for SPECC1L Gene
- GC22P022996
- GC22P007616
- GC22P024668
- GC22P024682
- GC22P024692
- GC22P024708
- GC22P024731
- GC22P024272
- GC22P024297
- GC22P024314
- GC22P024329
- GC22P024341
- GC22P024365
- GC22P024387
- GC22P024393
Summaries for SPECC1L Gene
-
This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
GeneCards Summary for SPECC1L Gene
SPECC1L (Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1 Like) is a Protein Coding gene. Diseases associated with SPECC1L include Facial Clefting, Oblique, 1 and Opitz Gbbb Syndrome, Type Ii. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is SPECC1L-ADORA2A.
UniProtKB/Swiss-Prot for SPECC1L Gene
-
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
Additional gene information for SPECC1L Gene
- Monarch Initiative
- Search for SPECC1L at DataMed
- Search for SPECC1L at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPECC1L Gene
Genomics for SPECC1L Gene
GeneHancer (GH) Regulatory Elements for SPECC1L Gene
Promoters and enhancers for SPECC1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPECC1L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SPECC1L Gene
Genomic Locations for SPECC1L Gene
- chr22:24,270,817-24,417,740
- (GRCh38/hg38)
- Size:
- 146,924 bases
- Orientation:
- Plus strand
- chr22:24,666,786-24,813,708
- (GRCh37/hg19)
- Size:
- 146,923 bases
- Orientation:
- Plus strand
Genomic View for SPECC1L Gene
Genes around SPECC1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by Entrez Gene
- 22q11.23 by HGNC
- 22q11.23 by Ensembl
SPECC1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPECC1L Gene
Proteins for SPECC1L Gene
-
Protein details for SPECC1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q69YQ0-CYTSA_HUMAN
- Recommended name:
- Cytospin-A
- Protein Accession:
- Q69YQ0
- B7Z758
- F5H1H6
- O15081
Protein attributes for SPECC1L Gene
- Size:
- 1117 amino acids
- Molecular mass:
- 124602 Da
- Quaternary structure:
-
- May interact with both microtubules and actin cytoskeleton.
Protein Expression for SPECC1L Gene
Post-translational modifications for SPECC1L Gene
Other Protein References for SPECC1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SPECC1L
- Novus Biologicals Antibodies for SPECC1L
- Invitrogen Antibodies for SPECC1L (AFLGC-SPECC1L)
- Search GeneTex for Antibodies for SPECC1L
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SPECC1L
- Origene Custom Protein Services for SPECC1L
- Novus Biologicals proteins for SPECC1L
- Search GeneTex for Proteins for SPECC1L
Assay Products
No data available for DME Specific Peptides for SPECC1L Gene
Domains & Families for SPECC1L Gene
Gene Families for SPECC1L Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for SPECC1L Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPECC1L Gene
Graphical View of Domain Structure for InterPro Entry
Q69YQ0- Family:
-
- Belongs to the cytospin-A family.
Function for SPECC1L Gene
Molecular function for SPECC1L Gene
- UniProtKB/Swiss-Prot Function:
- Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
Phenotypes From GWAS Catalog for SPECC1L Gene
Phenotypes for SPECC1L Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPECC1L
-
CRISPR Products
-
OriGene CRISPR knockouts for SPECC1L
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- genomics-online: gRNA clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- Applied Biological Materials CRISPR for SPECC1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPECC1L
- GenScript: Design CRISPR guide RNA sequences for SPECC1L
miRNA for SPECC1L Gene
- miRTarBase miRNAs that target SPECC1L
-
- hsa-mir-26b-5p (MIRT029692)
- hsa-mir-1301-3p (MIRT036003)
- hsa-mir-421 (MIRT039398)
- hsa-mir-18a-3p (MIRT040797)
- hsa-mir-484 (MIRT042319)
- hsa-mir-339-5p (MIRT042765)
- hsa-mir-186-5p (MIRT045308)
- hsa-mir-146a-3p (MIRT737640)
- hsa-mir-301a-5p (MIRT739618)
- hsa-mir-301b-5p (MIRT739628)
- hsa-mir-3921 (MIRT742970)
- hsa-mir-4294 (MIRT743782)
- hsa-mir-4433a-3p (MIRT744369)
- hsa-mir-4653-5p (MIRT746618)
- hsa-mir-4706 (MIRT747343)
- hsa-mir-4734 (MIRT747982)
- hsa-mir-4749-5p (MIRT748323)
- hsa-mir-4787-5p (MIRT748895)
- hsa-mir-593-3p (MIRT751591)
- hsa-mir-665 (MIRT753660)
- hsa-mir-744-5p (MIRT759370)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPECC1L
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- Overview of 90 available SPECC1L gene related products
Clone Products
- Sino Biological Human cDNA Clone for SPECC1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPECC1L
- Applied Biological Materials Clones for SPECC1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPECC1L
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SPECC1L Gene
Localization for SPECC1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPECC1L Gene
- Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell junction, gap junction. Note=Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| cytosol | 4 |
- Actin filaments (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005815 | microtubule organizing center | IBA | -- |
| GO:0005819 | spindle | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for SPECC1L Gene
No Data Available
Interacting Proteins for SPECC1L Gene
Selected Interacting proteins:
ENSP00000325785
Q69YQ0-CYTSA_HUMAN
for SPECC1L Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for SPECC1L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007155 | cell adhesion | IDA | 21703590 |
| GO:0030036 | actin cytoskeleton organization | IBA | -- |
| GO:0051301 | cell division | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPECC1L Gene
Drugs & Compounds for SPECC1L Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Methotrexate | Approved | Pharma | Folate antagonist,inhibits DFHR | 1603 |
Drug Products
Transcripts for SPECC1L Gene
mRNA/cDNA for SPECC1L Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (228) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000421374 2565 bps (uc062cjd.1)
- ENST00000314328 6756 bps (uc002zzw.5)
- ENST00000416735 566 bps (uc062cje.1)
- ENST00000541492 3525 bps (uc011ajq.4)
- ENST00000440893 612 bps (uc062cjh.1)
Unigene Clusters for SPECC1L Gene
- Sperm antigen with calponin homology and coiled-coil domains 1-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SPECC1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPECC1L
- genomics-online: gRNA clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- Applied Biological Materials CRISPR for SPECC1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPECC1L
- GenScript: Design CRISPR guide RNA sequences for SPECC1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPECC1L
- Browse OriGene Inhibitory RNA Products For SPECC1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPECC1L
- genomics-online: shRNA clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
Clone Products
- Sino Biological Human cDNA Clone for SPECC1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPECC1L
- Applied Biological Materials Clones for SPECC1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 19b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: |
Expression for SPECC1L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
This gene is overexpressed in Bone marrow stromal cell (20.3), Adrenal (13.2), and Cervix (12.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPECC1L Gene
NURSA nuclear receptor signaling pathways regulating expression of SPECC1L Gene:
SPECC1LSOURCE GeneReport for Unigene cluster for SPECC1L Gene:
Hs.474384Evidence on tissue expression from TISSUES for SPECC1L Gene
- Nervous system(4.8)
- Liver(4.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SPECC1L Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- epiglottis
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- middle ear
- mouth
- neck
- nose
- outer ear
- pharynx
- scalp
- skull
- tongue
- vocal cord
Thorax:
- aorta
- bronchus
- diaphragm
- esophagus
- heart
- heart valve
- lung
- trachea
Abdomen:
- abdominal wall
- gallbladder
- intestine
- kidney
- large intestine
- stomach
Pelvis:
- anus
- penis
- rectum
- testicle
- ureter
- urethra
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for SPECC1L
-
OriGene qPCR primer pairs and template standards for SPECC1L
- genomics-online: primer clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPECC1L Gene
Orthologs for SPECC1L Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPECC1L 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| SPECC1L 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | SPECC1L 34 33 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Specc1l 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Specc1l 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | SPECC1L 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | specc1l 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | specc1la 34 33 |
|
ManyToMany | |
| specc1lb 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG13366 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3677 34 |
|
OneToMany | |
| Cin.3747 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3747 33 |
|
- Species where no ortholog for SPECC1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SPECC1L Gene
- ENSEMBL:
- Gene Tree for SPECC1L (if available)
- TreeFam:
- Gene Tree for SPECC1L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPECC1L: view image
Paralogs for SPECC1L Gene
Paralogs for SPECC1L Gene
(3) SIMAP similar genes for SPECC1L Gene using alignment to 3 proteins:
- CYTSA_HUMAN
- C9J8U1_HUMAN
- C9JLY8_HUMAN
Variants for SPECC1L Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920978 | uncertain-significance, Malignant tumor of prostate | 24,321,444(+) | G/A/T | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs387907108 | pathogenic, Oculomaxillofacial dysostosis | 24,322,224(+) | A/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs786201030 | pathogenic, Opitz G/BBB syndrome | 24,322,169(+) | A/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs786201031 | pathogenic, Opitz G/BBB syndrome | 24,412,690(+) | G/A | coding_sequence_variant, missense_variant | |
| VAR_066873 | Facial clefting, oblique, 1 (OBLFC1) [MIM:600251] | p.Gln415Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4528n100 | CNV | gain | 25217958 |
| dgv8039n54 | CNV | gain | 21841781 |
| esv24290 | CNV | gain | 19812545 |
| esv2724041 | CNV | deletion | 23290073 |
| esv2724068 | CNV | deletion | 23290073 |
| esv3575443 | CNV | gain | 25503493 |
| esv3893463 | CNV | gain | 25118596 |
| esv996036 | CNV | deletion | 20482838 |
| nsv1055830 | CNV | gain | 25217958 |
| nsv1057819 | CNV | gain | 25217958 |
| nsv1110863 | OTHER | inversion | 24896259 |
| nsv526567 | CNV | gain | 19592680 |
| nsv588744 | CNV | gain | 21841781 |
| nsv7350 | OTHER | inversion | 18451855 |
| nsv834158 | CNV | gain | 17160897 |
| nsv834160 | CNV | gain | 17160897 |
| nsv953060 | CNV | duplication | 24416366 |
| nsv953061 | CNV | deletion | 24416366 |
| nsv964609 | CNV | duplication | 23825009 |
| nsv964610 | CNV | duplication | 23825009 |
| nsv966093 | CNV | duplication | 23825009 |
| nsv979658 | CNV | duplication | 23825009 |
| nsv9883 | CNV | gain+loss | 18304495 |
| nsv9884 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.67;
57.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPECC1L Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPECC1L Gene
Disorders for SPECC1L Gene
(11) MalaCards diseases for SPECC1L Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| facial clefting, oblique, 1 |
|
|
| opitz gbbb syndrome, type ii |
|
|
| opitz-gbbb syndrome |
|
|
| oculomaxillofacial dysostosis |
|
|
| hypertelorism, teebi type |
|
|
Search SPECC1L in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CYTSA_HUMAN- Facial clefting, oblique, 1 (OBLFC1) [MIM:600251]: A rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face. {ECO:0000269 PubMed:21703590}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Opitz GBBB syndrome 2 (GBBB2) [MIM:145410]: A form of Opitz GBBB syndrome, a congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, cleft lip/palate, laryngotracheoesophageal abnormalities, imperforate anus, developmental delay and congenital heart defects. {ECO:0000269 PubMed:25412741}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SPECC1L
No data available for Genatlas for SPECC1L Gene
Publications for SPECC1L Gene
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
- Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal dominant Opitz G/BBB syndrome. (PMID: 25412741) Kruszka P … Zackai EH (Journal of medical genetics 2015) 3 4 58
- Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting. (PMID: 21703590) Saadi I … Maas RL (American journal of human genetics 2011) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4 58
Products for SPECC1L Gene
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- GenScript: Design CRISPR guide RNA sequences for SPECC1L
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SPECC1L
- Sino Biological Human cDNA Clone for SPECC1L
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SPECC1L
- Novus Biologicals proteins for SPECC1L
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for SPECC1L (AFLGC-SPECC1L)
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPECC1L
- antibodies-online: Search results for 41 available SPECC1L Antibodies ranked by validation data
- Compare Top SPECC1L Antibodies
- antibodies-online: Search results for available SPECC1L related products ranked by validation data
- antibodies-online: Search results for available SPECC1L related products ranked by validation data
- Search GeneTex for Antibodies for SPECC1L
- Search GeneTex for Proteins for SPECC1L
- Horizon Cell Lines for SPECC1L
- genomics-online: cdna clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- orf clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- genomics-online: gRNA clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- genomics-online: primer clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- genomics-online: shRNA clones - Search results for 90 available SPECC1L gene related products
- Overview of 90 available SPECC1L gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPECC1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPECC1L
- GeneCopoeia miRNA 3'UTR Target clone products for SPECC1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPECC1L
Sources for SPECC1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt