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Aliases for SPDYE6 Gene

Aliases for SPDYE6 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E6 2 3 5
  • Speedy Homolog E6 (Xenopus Laevis) 2

External Ids for SPDYE6 Gene

Previous GeneCards Identifiers for SPDYE6 Gene

  • GC07M101778
  • GC07M101988
  • GC07M101346

Summaries for SPDYE6 Gene

Entrez Gene Summary for SPDYE6 Gene

  • This gene encodes a cell cycle regulatory protein which plays an important role in cell cycle progression by binding and activating cyclin-dependent kinases. The encoded protein belongs to a family of cyclin-dependent kinase regulators that contain a speedy box domain which is required for cyclin-dependent kinase activation. [provided by RefSeq, Jul 2017]

GeneCards Summary for SPDYE6 Gene

SPDYE6 (Speedy/RINGO Cell Cycle Regulator Family Member E6) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE2.

Additional gene information for SPDYE6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE6 Gene

Genomics for SPDYE6 Gene

GeneHancer (GH) Regulatory Elements for SPDYE6 Gene

Promoters and enhancers for SPDYE6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101947 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.1 +409.0 409046 1.6 HDAC1 ATF1 ARNT INSM2 ZNF213 EGR1 ZNF366 ZSCAN5C RCOR1 CREM UPK3BL1 SPDYE6 ENSG00000272219 GC07M101947 GC07P101859 CUX1
GH07I101706 Enhancer 0.8 ENCODE dbSUPER 5 +649.2 649170 1.8 SMARCA5 BCOR ZMYM3 NFXL1 ZNF335 CBX1 HDAC2 ADNP ZFP36 KDM1A SPDYE6 GC07M101683 GC07P101775
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPDYE6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPDYE6 gene promoter:

Genomic Locations for SPDYE6 Gene

Genomic Locations for SPDYE6 Gene
chr7:102,345,752-102,357,047
(GRCh38/hg38)
Size:
11,296 bases
Orientation:
Minus strand
chr7:101,986,192-101,996,889
(GRCh37/hg19)

Genomic View for SPDYE6 Gene

Genes around SPDYE6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE6 Gene

Proteins for SPDYE6 Gene

  • Protein details for SPDYE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CI01-SPDE6_HUMAN
    Recommended name:
    Putative speedy protein E6
    Protein Accession:
    P0CI01

    Protein attributes for SPDYE6 Gene

    Size:
    402 amino acids
    Molecular mass:
    48349 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE6 Gene

Post-translational modifications for SPDYE6 Gene

No Post-translational modifications

Other Protein References for SPDYE6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE6 Gene

Domains & Families for SPDYE6 Gene

Gene Families for SPDYE6 Gene

Protein Domains for SPDYE6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPDYE6: view

No data available for UniProtKB/Swiss-Prot for SPDYE6 Gene

Function for SPDYE6 Gene

Gene Ontology (GO) - Molecular Function for SPDYE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE6: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE6 Gene

Localization for SPDYE6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE6 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE6 Gene

Pathways & Interactions for SPDYE6 Gene

SuperPathways for SPDYE6 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE6: view

Pathways by source for SPDYE6 Gene

Interacting Proteins for SPDYE6 Gene

Gene Ontology (GO) - Biological Process for SPDYE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE6: view

No data available for SIGNOR curated interactions for SPDYE6 Gene

Drugs & Compounds for SPDYE6 Gene

No Compound Related Data Available

Transcripts for SPDYE6 Gene

mRNA/cDNA for SPDYE6 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE6 Gene

No ASD Table

Relevant External Links for SPDYE6 Gene

GeneLoc Exon Structure for
SPDYE6
ECgene alternative splicing isoforms for
SPDYE6

Expression for SPDYE6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE6 Gene

mRNA differential expression in normal tissues according to GTEx for SPDYE6 Gene

This gene is overexpressed in Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of SPDYE6 Gene:

SPDYE6
genes like me logo Genes that share expression patterns with SPDYE6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE6 Gene

Orthologs for SPDYE6 Gene

Evolution for SPDYE6 Gene

ENSEMBL:
Gene Tree for SPDYE6 (if available)
TreeFam:
Gene Tree for SPDYE6 (if available)

No data available for Orthologs for SPDYE6 Gene

Paralogs for SPDYE6 Gene

Paralogs for SPDYE6 Gene

(9) SIMAP similar genes for SPDYE6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPDYE6 Gene

genes like me logo Genes that share paralogs with SPDYE6: view

Variants for SPDYE6 Gene

Sequence variations from dbSNP and Humsavar for SPDYE6 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs10232123 -- 102,350,313(-) A/G intron_variant
rs10232255 -- 102,350,440(-) A/G intron_variant
rs10232260 -- 102,350,452(-) A/G intron_variant
rs10261877 -- 102,350,363(-) G/A intron_variant
rs1059797 -- 102,347,229(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE6 Gene

Variant ID Type Subtype PubMed ID
nsv971402 CNV duplication 23825009
nsv971401 CNV duplication 23825009
nsv971046 CNV duplication 23825009
nsv970918 CNV duplication 23825009
nsv831083 CNV loss 17160897
nsv831082 CNV gain 17160897
nsv8190 CNV gain+loss 18304495
nsv428182 CNV gain 18775914
nsv1147387 CNV duplication 26484159
nsv1077496 CNV duplication 25765185
esv3614348 CNV gain 21293372
esv2759548 CNV gain 17122850
esv2734944 CNV deletion 23290073
esv2673677 CNV deletion 23128226
esv26209 CNV gain 19812545
dgv6538n100 CNV gain 25217958
dgv3891e59 CNV duplication 20981092
dgv3890e59 CNV duplication 20981092
dgv3889e59 CNV duplication 20981092
dgv3632n106 CNV duplication 24896259

Additional Variant Information for SPDYE6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPDYE6 Gene

Disorders for SPDYE6 Gene

Additional Disease Information for SPDYE6

No disorders were found for SPDYE6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE6 Gene

Publications for SPDYE6 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  2. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PMID: 22763696) Chauhan S … Kaldis P (Cellular and molecular life sciences : CMLS 2012) 3 58
  3. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. (PMID: 21630153) Gopinathan L … Kaldis P (Results and problems in cell differentiation 2011) 3 58
  4. CDK activation by non-cyclin proteins. (PMID: 16488127) Nebreda AR (Current opinion in cell biology 2006) 3 58
  5. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PMID: 15611625) Cheng A … Solomon MJ (Cell cycle (Georgetown, Tex.) 2005) 3 58

Products for SPDYE6 Gene

Sources for SPDYE6 Gene

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