Aliases for SPDYE5 Gene

Aliases for SPDYE5 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E5 2 3 5
  • Speedy Protein E5 3 4
  • Speedy Homolog E5 (Xenopus Laevis) 2
  • Putative Speedy Protein E5 3
  • Speedy Homolog E5 3

External Ids for SPDYE5 Gene

Previous GeneCards Identifiers for SPDYE5 Gene

  • GC07P074964
  • GC07P075123
  • GC07P074457

Summaries for SPDYE5 Gene

GeneCards Summary for SPDYE5 Gene

SPDYE5 (Speedy/RINGO Cell Cycle Regulator Family Member E5) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE6.

Additional gene information for SPDYE5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPDYE5 Gene

Genomics for SPDYE5 Gene

GeneHancer (GH) Regulatory Elements for SPDYE5 Gene

Promoters and enhancers for SPDYE5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPDYE5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPDYE5 gene promoter:
  • AML1a
  • E47
  • Evi-1
  • Hand1
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SPDYE5 Gene

Genomic Locations for SPDYE5 Gene
chr7:75,493,182-75,504,304
(GRCh38/hg38)
Size:
11,123 bases
Orientation:
Plus strand
chr7:75,123,401-75,133,628
(GRCh37/hg19)
Size:
10,228 bases
Orientation:
Plus strand

Genomic View for SPDYE5 Gene

Genes around SPDYE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE5 Gene

Proteins for SPDYE5 Gene

  • Protein details for SPDYE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIY4-SPDE5_HUMAN
    Recommended name:
    Speedy protein E5
    Protein Accession:
    A6NIY4
    Secondary Accessions:
    • A0A096LPK5

    Protein attributes for SPDYE5 Gene

    Size:
    402 amino acids
    Molecular mass:
    47997 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE5 Gene

Post-translational modifications for SPDYE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE5 Gene

Domains & Families for SPDYE5 Gene

Gene Families for SPDYE5 Gene

Protein Domains for SPDYE5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE5 Gene

GenScript: Design optimal peptide antigens:
  • Putative speedy protein E5 (SPDE5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NIY4

UniProtKB/Swiss-Prot:

SPDE5_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE5: view

Function for SPDYE5 Gene

Phenotypes From GWAS Catalog for SPDYE5 Gene

Gene Ontology (GO) - Molecular Function for SPDYE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with SPDYE5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPDYE5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE5 Gene

Localization for SPDYE5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE5 Gene

Pathways & Interactions for SPDYE5 Gene

PathCards logo

SuperPathways for SPDYE5 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE5: view

Pathways by source for SPDYE5 Gene

Interacting Proteins for SPDYE5 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000485398 for SPDYE5 Gene via STRING

Gene Ontology (GO) - Biological Process for SPDYE5 Gene

None

No data available for SIGNOR curated interactions for SPDYE5 Gene

Drugs & Compounds for SPDYE5 Gene

No Compound Related Data Available

Transcripts for SPDYE5 Gene

mRNA/cDNA for SPDYE5 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPDYE5

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE5 Gene

No ASD Table

Relevant External Links for SPDYE5 Gene

GeneLoc Exon Structure for
SPDYE5
ECgene alternative splicing isoforms for
SPDYE5

Expression for SPDYE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE5 Gene

mRNA expression in normal human tissues for SPDYE5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPDYE5 Gene:

SPDYE5

SOURCE GeneReport for Unigene cluster for SPDYE5 Gene:

Hs.632298
genes like me logo Genes that share expression patterns with SPDYE5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE5 Gene

Orthologs for SPDYE5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPDYE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC742265 32
  • 98.25 (n)
Species where no ortholog for SPDYE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE5 Gene

ENSEMBL:
Gene Tree for SPDYE5 (if available)
TreeFam:
Gene Tree for SPDYE5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPDYE5: view image

Paralogs for SPDYE5 Gene

(9) SIMAP similar genes for SPDYE5 Gene using alignment to 1 proteins:

  • SPDE5_HUMAN
genes like me logo Genes that share paralogs with SPDYE5: view

Variants for SPDYE5 Gene

Sequence variations from dbSNP and Humsavar for SPDYE5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs10230587 -- 75,494,283(+) C/A/T intron_variant
rs10274653 -- 75,491,667(+) C/T upstream_transcript_variant
rs10441325 -- 75,494,456(+) C/A/G/T intron_variant
rs1062117 -- 75,493,577(+) G/A upstream_transcript_variant
rs111295044 -- 75,494,029(+) C/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE5 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv3858e59 CNV duplication 20981092
esv21917 CNV gain 19812545
esv3613722 CNV loss 21293372
nsv482105 CNV gain 20164927
nsv528969 CNV gain 19592680
nsv607509 CNV gain 21841781
nsv8157 CNV gain+loss 18304495
nsv831036 CNV loss 17160897
nsv971041 CNV duplication 23825009
nsv981535 CNV duplication 23825009

Additional Variant Information for SPDYE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPDYE5 Gene

Disorders for SPDYE5 Gene

Additional Disease Information for SPDYE5

No disorders were found for SPDYE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE5 Gene

Publications for SPDYE5 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 56
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for SPDYE5 Gene

Sources for SPDYE5 Gene