Aliases for SPDYE4 Gene

Aliases for SPDYE4 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E4 2 3 5
  • Speedy Protein E4 3 4
  • Speedy Homolog E4 (Xenopus Laevis) 2
  • Putative Speedy Protein E4 3
  • Speedy Homolog E4 3

External Ids for SPDYE4 Gene

Previous GeneCards Identifiers for SPDYE4 Gene

  • GC17M008599
  • GC17M008656

Summaries for SPDYE4 Gene

GeneCards Summary for SPDYE4 Gene

SPDYE4 (Speedy/RINGO Cell Cycle Regulator Family Member E4) is a Protein Coding gene. Diseases associated with SPDYE4 include Behcet Syndrome. Among its related pathways are Oocyte meiosis. An important paralog of this gene is ENSG00000230358.

Additional gene information for SPDYE4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPDYE4 Gene

Genomics for SPDYE4 Gene

GeneHancer (GH) Regulatory Elements for SPDYE4 Gene

Promoters and enhancers for SPDYE4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J008758 Promoter 0.4 EPDnew 500.7 +0.9 918 0.1 ATF2 SPDYE4 lnc-NDEL1-7
GH17J008744 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 18.8 +13.6 13578 2.3 HNRNPK CTCF ZSCAN5C TCF12 NCOR1 POLR2A ZNF423 ZBTB26 RFX1 TGIF2 CCDC42 LOC105371529 lnc-NDEL1-7 SPDYE4 ODF4 MFSD6L
GH17J008364 Enhancer 0.9 FANTOM5 Ensembl ENCODE 46.5 +393.4 393431 2.4 STAT3 STAT1 ATF2 JUN FOS POLR2A CEBPB ZNF600 ENSG00000265749 RF00017-2273 piR-31432-273 piR-53431-275 ODF4 CCDC42 SPDYE4 ENSG00000212206 ENSG00000226871 RNF222
GH17J008951 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 -199.9 -199910 16.6 ZBTB40 SIN3A SP1 EP300 POLR2A ZBTB26 JUND RELA TRIM22 EZH2 PIK3R5 SPDYE4 ENSG00000265975 ENSG00000266389 CTB-41I6.1 lnc-PIK3R6-2 piR-61945-195
GH17J008933 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 13.9 -175.7 -175659 2.3 RFX1 RELA POLR2A FOS SRF BATF STAT3 IKZF1 JUNB ATF2 PIK3R5 SPDYE4 NTN1 NDEL1 piR-61945-195 piR-38736-009 lnc-PIK3R6-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPDYE4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPDYE4

Top Transcription factor binding sites by QIAGEN in the SPDYE4 gene promoter:
  • CP1A
  • CP1C
  • Evi-1
  • NF-Y
  • NF-YA
  • NF-YB
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SPDYE4 Gene

Genomic Locations for SPDYE4 Gene
chr17:8,746,868-8,759,412
(GRCh38/hg38)
Size:
12,545 bases
Orientation:
Minus strand
chr17:8,656,424-8,661,877
(GRCh37/hg19)
Size:
5,454 bases
Orientation:
Minus strand

Genomic View for SPDYE4 Gene

Genes around SPDYE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE4 Gene

Proteins for SPDYE4 Gene

  • Protein details for SPDYE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLX3-SPDE4_HUMAN
    Recommended name:
    Speedy protein E4
    Protein Accession:
    A6NLX3
    Secondary Accessions:
    • B2RUZ6

    Protein attributes for SPDYE4 Gene

    Size:
    237 amino acids
    Molecular mass:
    27806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE4 Gene

Post-translational modifications for SPDYE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE4 Gene

No data available for DME Specific Peptides for SPDYE4 Gene

Domains & Families for SPDYE4 Gene

Gene Families for SPDYE4 Gene

Protein Domains for SPDYE4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE4 Gene

GenScript: Design optimal peptide antigens:
  • Speedy protein E4 (SPDE4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NLX3

UniProtKB/Swiss-Prot:

SPDE4_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE4: view

Function for SPDYE4 Gene

Phenotypes From GWAS Catalog for SPDYE4 Gene

Gene Ontology (GO) - Molecular Function for SPDYE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with SPDYE4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE4 Gene

Localization for SPDYE4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE4 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE4 Gene

Pathways & Interactions for SPDYE4 Gene

PathCards logo

SuperPathways for SPDYE4 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE4: view

Pathways by source for SPDYE4 Gene

Interacting Proteins for SPDYE4 Gene

;

Gene Ontology (GO) - Biological Process for SPDYE4 Gene

None

No data available for SIGNOR curated interactions for SPDYE4 Gene

Drugs & Compounds for SPDYE4 Gene

No Compound Related Data Available

Transcripts for SPDYE4 Gene

mRNA/cDNA for SPDYE4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE4 Gene

No ASD Table

Relevant External Links for SPDYE4 Gene

GeneLoc Exon Structure for
SPDYE4

Expression for SPDYE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPDYE4 Gene

mRNA differential expression in normal tissues according to GTEx for SPDYE4 Gene

This gene is overexpressed in Testis (x41.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPDYE4

SOURCE GeneReport for Unigene cluster for SPDYE4 Gene:

Hs.368429
genes like me logo Genes that share expression patterns with SPDYE4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE4 Gene

Orthologs for SPDYE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDYE4 31 30
  • 98.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607286 30
  • 80.21 (n)
-- 31
  • 76 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 4933411G11Rik 31
  • 54 (a)
ManyToMany
Spdyb 31
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToMany
Species where no ortholog for SPDYE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE4 Gene

ENSEMBL:
Gene Tree for SPDYE4 (if available)
TreeFam:
Gene Tree for SPDYE4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPDYE4: view image

Paralogs for SPDYE4 Gene

(9) SIMAP similar genes for SPDYE4 Gene using alignment to 3 proteins:

  • SPDE4_HUMAN
  • J3KT05_HUMAN
  • J3QR45_HUMAN
genes like me logo Genes that share paralogs with SPDYE4: view

Variants for SPDYE4 Gene

Additional dbSNP identifiers (rs#s) for SPDYE4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPDYE4 Gene

Variant ID Type Subtype PubMed ID
esv2761945 CNV loss 21179565
esv3639890 CNV gain 21293372
nsv518675 CNV gain 19592680
nsv960406 CNV duplication 23825009

Variation tolerance for SPDYE4 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPDYE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPDYE4 Gene

Disorders for SPDYE4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPDYE4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
behcet syndrome
  • behcet disease; bd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPDYE4

genes like me logo Genes that share disorders with SPDYE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPDYE4 Gene

Publications for SPDYE4 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for SPDYE4 Gene

Sources for SPDYE4 Gene