Aliases for SPDYE2B Gene
Aliases for SPDYE2B Gene
External Ids for SPDYE2B Gene
- HGNC: 48334
- Entrez Gene: 100310812
- Ensembl: ENSG00000173678
- UniProtKB: A6NHP3
Previous GeneCards Identifiers for SPDYE2B Gene
- GC07P102291
Summaries for SPDYE2B Gene
GeneCards Summary for SPDYE2B Gene
SPDYE2B (Speedy/RINGO Cell Cycle Regulator Family Member E2B) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE6.
Additional gene information for SPDYE2B Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE2B Gene
Genomics for SPDYE2B Gene
GeneHancer (GH) Regulatory Elements for SPDYE2B Gene
Promoters and enhancers for SPDYE2B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07I102650 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -25 | 0.1 | PIR42908 SPDYE2B POLR2J2 ENSG00000267645 ENSG00000279168 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SPDYE2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SPDYE2B Gene
Genomic Locations for SPDYE2B Gene
- chr7:102,650,325-102,661,400
- (GRCh38/hg38)
- Size:
- 11,076 bases
- Orientation:
- Plus strand
- chr7:102,290,772-102,301,847
- (GRCh37/hg19)
Genomic View for SPDYE2B Gene
Genes around SPDYE2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22.1 by Entrez Gene
- 7q22.1 by HGNC
SPDYE2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPDYE2B Gene
Proteins for SPDYE2B Gene
-
Protein details for SPDYE2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NHP3-SPE2B_HUMAN
- Recommended name:
- Speedy protein E2B
- Protein Accession:
- A6NHP3
- D6RBN0
Protein attributes for SPDYE2B Gene
- Size:
- 402 amino acids
- Molecular mass:
- 48290 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for SPDYE2B Gene
Other Protein References for SPDYE2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SPDYE2B
- Origene Custom Protein Services for SPDYE2B
- Search GeneTex for Proteins for SPDYE2B
Assay Products
No data available for DME Specific Peptides for SPDYE2B Gene
Domains & Families for SPDYE2B Gene
Gene Families for SPDYE2B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for SPDYE2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6NHP3- Family:
-
- Belongs to the Speedy/Ringo family.
Function for SPDYE2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019901 | protein kinase binding | IBA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPDYE2B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPDYE2B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPDYE2B gene
- Search ViGene Biosciences for SPDYE2B
CRISPR Products
-
OriGene CRISPR knockouts for SPDYE2B
- genomics-online: gRNA clones - Search results for available SPDYE2B gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPDYE2B
- GenScript: Design CRISPR guide RNA sequences for SPDYE2B
miRNA Products
- Search ViGene Biosciences for SPDYE2B
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available SPDYE2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPDYE2B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SPDYE2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPDYE2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SPDYE2B gene related products
- orf clones - Search results for available SPDYE2B gene related products
Cell Line Products
-
Horizon Cell Lines for SPDYE2B
-
ViGene Biosciences adenoviral particle packaged cDNA for SPDYE2B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPDYE2B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPDYE2B gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE2B Gene
Localization for SPDYE2B Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE2B Gene
Pathways & Interactions for SPDYE2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Oocyte meiosis |
.41
|
|
Pathways by source for SPDYE2B Gene
2 KEGG pathways for SPDYE2B Gene
Interacting Proteins for SPDYE2B Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| CDC25C |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045859 | regulation of protein kinase activity | IBA | -- |
No data available for SIGNOR curated interactions for SPDYE2B Gene
Transcripts for SPDYE2B Gene
mRNA/cDNA for SPDYE2B Gene
- (3) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for SPDYE2B
- genomics-online: gRNA clones - Search results for available SPDYE2B gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPDYE2B
- GenScript: Design CRISPR guide RNA sequences for SPDYE2B
miRNA Products
- Search ViGene Biosciences for SPDYE2B
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available SPDYE2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPDYE2B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SPDYE2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPDYE2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SPDYE2B gene related products
- orf clones - Search results for available SPDYE2B gene related products
Expression for SPDYE2B Gene
mRNA differential expression in normal tissues according to GTEx for SPDYE2B Gene
This gene is overexpressed in Testis (x9.2).
NURSA nuclear receptor signaling pathways regulating expression of SPDYE2B Gene:
SPDYE2BPrimer Products
- genomics-online: primer clones - Search results for available SPDYE2B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE2B Gene
Orthologs for SPDYE2B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | 4933411G11Rik 34 |
|
ManyToMany | |
| Spdyb 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SPDYE2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SPDYE2B Gene
Paralogs for SPDYE2B Gene
(9) SIMAP similar genes for SPDYE2B Gene using alignment to 1 proteins:
Variants for SPDYE2B Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1044151489 | -- | 102,656,362(+) | C/T | intron_variant | |
| rs1052676193 | -- | 102,663,557(+) | G/A | downstream_transcript_variant | |
| rs1059798 | -- | 102,661,090(+) | T/C | 3_prime_UTR_variant, intron_variant | |
| rs111320873 | -- | 102,663,581(+) | C/T | downstream_transcript_variant | |
| rs111553311 | -- | 102,660,858(+) | A/G | 3_prime_UTR_variant, intron_variant |
Additional Variant Information for SPDYE2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPDYE2B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPDYE2B Gene
Disorders for SPDYE2B Gene
Additional Disease Information for SPDYE2B
No disorders were found for SPDYE2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE2B Gene
Publications for SPDYE2B Gene
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
Products for SPDYE2B Gene
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SPDYE2B
- Origene Custom Protein Services for SPDYE2B
- Browse OriGene Inhibitory RNA Products For SPDYE2B
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for SPDYE2B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for SPDYE2B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SPDYE2B
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- GenScript: Design CRISPR guide RNA sequences for SPDYE2B
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPDYE2B
- VectorBuilder custom plasmid, inducible vectors for SPDYE2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPDYE2B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for SPDYE2B
- Search GeneTex for Proteins for SPDYE2B
- ViGene Biosciences adenoviral particle packaged cDNA for SPDYE2B gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPDYE2B gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPDYE2B gene
- Search ViGene Biosciences for SPDYE2B
- Horizon Cell Lines for SPDYE2B
- genomics-online: cdna clones - Search results for available SPDYE2B gene related products
- orf clones - Search results for available SPDYE2B gene related products
- genomics-online: gRNA clones - Search results for available SPDYE2B gene related products
- genomics-online: primer clones - Search results for available SPDYE2B gene related products
- genomics-online: shRNA clones - Search results for available SPDYE2B gene related products
Sources for SPDYE2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
