SPDYE2B Gene (Protein Coding)

Speedy/RINGO Cell Cycle Regulator Family Member E2B

GC07P102651
GIFtS:
20
See more...

Aliases for SPDYE2B Gene

Aliases for SPDYE2B Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E2B 2 3 5
  • Speedy Protein E2B 3 4
  • Putative Speedy Protein E2-Like Protein 3
  • Putative WBSCR19-Like Protein 3 3
  • WBSCR19-Like Protein 3 3
  • SPDYE2L 3
  • SPDYE2B 5

External Ids for SPDYE2B Gene

Previous GeneCards Identifiers for SPDYE2B Gene

  • GC07P102291
  • GC07P102650

Summaries for SPDYE2B Gene

GeneCards Summary for SPDYE2B Gene

SPDYE2B (Speedy/RINGO Cell Cycle Regulator Family Member E2B) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE6.

Additional gene information for SPDYE2B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPDYE2B Gene

Genomics for SPDYE2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SPDYE2B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J102670 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 0.4 +22.5 22479 3.2 IKZF1 CTCF HDAC1 SCRT2 NRF1 POLR2A SMARCA5 TAF9B ZBTB2 ZBTB40 ENSG00000267645 POLR2J2 RASA4 piR-48777-003 ENSG00000279168 SPDYE2B
GH07J102642 Promoter/Enhancer 0.5 EPDnew Ensembl 0.4 -6.0 -6005 1.4 ENSG00000205236 UPK3BL1 piR-55735-003 piR-57133-564 SPDYE2B ENSG00000267645 POLR2J2 ENSG00000279168
GH07J102645 Enhancer 0.3 Ensembl 0.7 -3.4 -3421 1.4 IKZF1 piR-57133-564 ENSG00000205236 SPDYE2B ENSG00000267645 POLR2J2 ENSG00000279168
GH07J102666 Promoter 0.3 EPDnew 0.4 +17.1 17092 0.1 piR-36672-004 piR-40019-007 piR-48777-003 piR-45684-007 piR-43876-004 ENSG00000267645 POLR2J2 ENSG00000279168 SPDYE2B
GH07J102662 Enhancer 0.2 Ensembl 0.4 +13.9 13879 0.4 piR-40019-007 piR-34932-016 piR-54194-008 ENSG00000267645 POLR2J2 SPDYE2B ENSG00000279168
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPDYE2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPDYE2B

Genomic Locations for SPDYE2B Gene

Genomic Locations for SPDYE2B Gene
chr7:102,649,122-102,663,525
(GRCh38/hg38)
Size:
14,404 bases
Orientation:
Plus strand
chr7:102,290,772-102,301,847
(GRCh37/hg19)
Size:
11,076 bases
Orientation:
Plus strand

Genomic View for SPDYE2B Gene

Genes around SPDYE2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPDYE2B Gene

Proteins for SPDYE2B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SPDYE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHP3-SPE2B_HUMAN
    Recommended name:
    Speedy protein E2B
    Protein Accession:
    A6NHP3
    Secondary Accessions:
    • D6RBN0

    Protein attributes for SPDYE2B Gene

    Size:
    402 amino acids
    Molecular mass:
    48290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYE2B Gene

Post-translational modifications for SPDYE2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE2B Gene

Domains & Families for SPDYE2B Gene

Gene Families for SPDYE2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPDYE2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE2B Gene

GenScript: Design optimal peptide antigens:
  • Putative speedy protein E2-like protein (SPE2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NHP3

UniProtKB/Swiss-Prot:

SPE2B_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE2B: view

Function for SPDYE2B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for SPDYE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with SPDYE2B: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPDYE2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE2B Gene

Localization for SPDYE2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE2B gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE2B Gene

Pathways & Interactions for SPDYE2B Gene

PathCards logo

SuperPathways for SPDYE2B Gene

SuperPathway Contained pathways
1 Oocyte meiosis
Oocyte meiosis
.44
Progesterone-mediated oocyte maturation
.44
genes like me logo Genes that share pathways with SPDYE2B: view

Pathways by source for SPDYE2B Gene

2 KEGG pathways for SPDYE2B Gene

Interacting Proteins for SPDYE2B Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000424058 for SPDYE2B Gene via STRING

GPS-Prot Interaction Network for SPDYE2B

Gene Ontology (GO) - Biological Process for SPDYE2B Gene

None

No data available for SIGNOR curated interactions for SPDYE2B Gene

Drugs & Compounds for SPDYE2B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SPDYE2B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SPDYE2B Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPDYE2B

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE2B Gene

No ASD Table

Relevant External Links for SPDYE2B Gene

GeneLoc Exon Structure for
SPDYE2B

Expression for SPDYE2B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPDYE2B Gene

mRNA expression in normal human tissues for SPDYE2B Gene
mRNA expression by GTEx for SPDYE2B Gene

mRNA differential expression in normal tissues according to GTEx for SPDYE2B Gene

This gene is overexpressed in Testis (x9.2).
genes like me logo Genes that share expression patterns with SPDYE2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE2B Gene

Orthologs for SPDYE2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 90 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia -- 31
  • 66 (a)
 ManyToMany
-- 31
  • 66 (a)
 ManyToMany
Cow
(Bos Taurus)
 Mammalia -- 31
  • 49 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia 4933411G11Rik 31
  • 49 (a)
 ManyToMany
Spdyb 31
  • 48 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 35 (a)
 ManyToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 34 (a)
 ManyToMany
-- 31
  • 33 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 20 (a)
 OneToMany
Species where no ortholog for SPDYE2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPDYE2B Gene

ENSEMBL:
Gene Tree for SPDYE2B (if available)
TreeFam:
Gene Tree for SPDYE2B (if available)

Paralogs for SPDYE2B Gene

Paralogs for SPDYE2B Gene

(9) SIMAP similar genes for SPDYE2B Gene using alignment to 1 proteins:

  • SPE2B_HUMAN
genes like me logo Genes that share paralogs with SPDYE2B: view

Variants for SPDYE2B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for SPDYE2B Gene

Structural Variations from Database of Genomic Variants (DGV) for SPDYE2B Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3899e59 CNV duplication 20981092
dgv3900e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3906e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
dgv6541n100 CNV gain 25217958
esv2734946 CNV deletion 23290073
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3327844 CNV duplication 20981092
esv3335589 CNV duplication 20981092
esv3343524 CNV duplication 20981092
esv3377591 CNV duplication 20981092
esv3400561 CNV duplication 20981092
esv3424897 CNV duplication 20981092
esv3891168 CNV gain+loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1027221 CNV loss 25217958
nsv1034233 CNV loss 25217958
nsv1110493 CNV duplication 24896259
nsv1119231 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1149718 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv433392 CNV gain 18776910
nsv436086 CNV insertion 17901297
nsv436552 CNV deletion 17901297
nsv469620 CNV loss 16826518
nsv469682 CNV gain+loss 16826518
nsv471643 CNV gain+loss 15918152
nsv482113 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv499529 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv608055 CNV gain 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv967349 CNV duplication 23825009
nsv970562 CNV duplication 23825009
nsv970563 CNV duplication 23825009
nsv970921 CNV duplication 23825009
nsv981562 CNV duplication 23825009
nsv981563 CNV duplication 23825009
nsv981678 CNV duplication 23825009

Additional Variant Information for SPDYE2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SPDYE2B Gene

Disorders for SPDYE2B Gene

Additional Disease Information for SPDYE2B

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for SPDYE2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE2B Gene

Publications for SPDYE2B Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for SPDYE2B gene in Mastermind

Products for SPDYE2B Gene

Sources for SPDYE2B Gene