SPDYC Gene (Protein Coding)

Speedy/RINGO Cell Cycle Regulator Family Member C

GC11P065170
GIFtS:
29
See more...

Aliases for SPDYC Gene

Aliases for SPDYC Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member C 2 3 5
  • Rapid Inducer Of G2/M Progression In Oocytes C 3 4
  • Speedy Protein C 3 4
  • HSpy/Ringo C 3 4
  • RINGO C 3 4
  • Ringo2 2 3
  • Speedy Homolog C (Xenopus Laevis) 2
  • Speedy Homolog C 3
  • RINGOC 3
  • SPDYC 5

External Ids for SPDYC Gene

Previous GeneCards Identifiers for SPDYC Gene

  • GC11P064694
  • GC11P064937
  • GC11P061264

Summaries for SPDYC Gene

GeneCards Summary for SPDYC Gene

SPDYC (Speedy/RINGO Cell Cycle Regulator Family Member C) is a Protein Coding gene. Diseases associated with SPDYC include Phosphoglycerate Kinase 1 Deficiency. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYA.

UniProtKB/Swiss-Prot Summary for SPDYC Gene

  • Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

Additional gene information for SPDYC Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPDYC Gene

Genomics for SPDYC Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SPDYC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J065168 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 278.3 -0.4 -393 3.1 TBP MNT SMAD5 IRF2 MBD2 BHLHE40 NONO ZNF395 GTF2E2 NFATC3 SPDYC CAPN1 EIF1AD PCNX3 SF1 LOC728975 POLA2 ZFPL1 SF3B2 ENSG00000257086
GH11J065129 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 33.4 -36.9 -36881 7.2 CHD2 TBP ZBTB10 SP1 MXD4 SIX5 NR2C1 MNT IKZF1 BRCA1 SYVN1 lnc-FAU-1 lnc-MRPL49-1 piR-49970 SPDYC PCNX3 SF1 POLA2 EIF1AD ZFPL1
GH11J065288 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +125.6 125643 14.5 CHD2 MXD4 CEBPA IKZF1 BRCA1 KDM6A THAP11 CEBPB SIN3A FOXA2 CDC42EP2 POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC PGAM1P8
GH11J065149 Enhancer 0.9 ENCODE 22.3 -18.6 -18584 3.4 TBP DEK IKZF1 HES1 ZIC2 CEBPB ZNF395 GTF2E2 VEZF1 NBN SPDYC MRPL49 PGAM1P8 CAPN1 LOC728975 FAU ZNHIT2 POLA2 SF3B2 RF00004-025
GH11J065180 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.5 +12.6 12626 5.2 ZBTB10 MNT IKZF1 ZNF217 CTCF BRCA1 BHLHE40 ZBTB7B ELF1 ZIC2 LOC728975 CAPN1 HSALNG0084867 SPDYC POLA2 HSALNG0084868
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPDYC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPDYC

Top Transcription factor binding sites by QIAGEN in the SPDYC gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • GATA-2
  • GATA-3
  • ITF-2
  • Tal-1beta

Genomic Locations for SPDYC Gene

Latest Assembly
chr11:65,170,154-65,173,666
(GRCh38/hg38)
Size:
3,513 bases
Orientation:
Plus strand

Previous Assembly
chr11:64,937,625-64,940,715
(GRCh37/hg19 by Entrez Gene)
Size:
3,091 bases
Orientation:
Plus strand

chr11:64,937,625-64,940,715
(GRCh37/hg19 by Ensembl)
Size:
3,091 bases
Orientation:
Plus strand

Genomic View for SPDYC Gene

Genes around SPDYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPDYC Gene

Proteins for SPDYC Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SPDYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ68-SPDYC_HUMAN
    Recommended name:
    Speedy protein C
    Protein Accession:
    Q5MJ68
    Secondary Accessions:
    • B2RP32
    • B7ZMH7

    Protein attributes for SPDYC Gene

    Size:
    293 amino acids
    Molecular mass:
    33166 Da
    Quaternary structure:
    • Interacts with CDK1 and CDK2. Interacts with AURKB.

neXtProt entry for SPDYC Gene

Post-translational modifications for SPDYC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYC Gene

Domains & Families for SPDYC Gene

Gene Families for SPDYC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPDYC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYC Gene

GenScript: Design optimal peptide antigens:
  • Rapid inducer of G2/M progression in oocytes C (SPDYC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5MJ68

UniProtKB/Swiss-Prot:

SPDYC_HUMAN :
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
  • Belongs to the Speedy/Ringo family.
Domain:
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYC: view

Function for SPDYC Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for SPDYC Gene

UniProtKB/Swiss-Prot Function:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

Phenotypes From GWAS Catalog for SPDYC Gene

Gene Ontology (GO) - Molecular Function for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0019901 protein kinase binding IPI 15611625
genes like me logo Genes that share ontologies with SPDYC: view

Phenotypes for SPDYC Gene

GenomeRNAi human phenotypes for SPDYC:
genes like me logo Genes that share phenotypes with SPDYC: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPDYC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYC Gene

Localization for SPDYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDYC Gene

Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYC gene
Compartment Confidence
nucleus 4
extracellular 1
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPDYC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPDYC Gene

Pathways & Interactions for SPDYC Gene

PathCards logo

SuperPathways for SPDYC Gene

SuperPathway Contained pathways
1 Oocyte meiosis
Oocyte meiosis
.44
Progesterone-mediated oocyte maturation
.44
genes like me logo Genes that share pathways with SPDYC: view

Pathways by source for SPDYC Gene

Gene Ontology (GO) - Biological Process for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with SPDYC: view

No data available for SIGNOR curated interactions for SPDYC Gene

Drugs & Compounds for SPDYC Gene

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No Compound Related Data Available

Transcripts for SPDYC Gene

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mRNA/cDNA for SPDYC Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPDYC

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYC Gene

No ASD Table

Relevant External Links for SPDYC Gene

GeneLoc Exon Structure for
SPDYC

Expression for SPDYC Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPDYC Gene

mRNA expression in normal human tissues for SPDYC Gene
mRNA expression by BioGPS for SPDYC GenemRNA expression by GTEx for SPDYC Gene

mRNA differential expression in normal tissues according to GTEx for SPDYC Gene

This gene is overexpressed in Liver (x20.1), Whole Blood (x11.3), and Testis (x8.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPDYC

SOURCE GeneReport for Unigene cluster for SPDYC Gene:

Hs.450642

mRNA Expression by UniProt/SwissProt for SPDYC Gene:

Q5MJ68-SPDYC_HUMAN
Tissue specificity: Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
genes like me logo Genes that share expression patterns with SPDYC: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYC Gene

Orthologs for SPDYC Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SPDYC 30 31
  • 98.98 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SPDYC 30 31
  • 83.91 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SPDYC 30 31
  • 79.9 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SPDYC 31
  • 57 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SPDYC 31
  • 52 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gm355 31
  • 32 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100488624 30
  • 56.82 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 30 (a)
 OneToMany
Species where no ortholog for SPDYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPDYC Gene

ENSEMBL:
Gene Tree for SPDYC (if available)
TreeFam:
Gene Tree for SPDYC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPDYC: view image

Paralogs for SPDYC Gene

Paralogs for SPDYC Gene

(1) SIMAP similar genes for SPDYC Gene using alignment to 1 proteins:

  • SPDYC_HUMAN
genes like me logo Genes that share paralogs with SPDYC: view

Variants for SPDYC Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPDYC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPDYC Gene

Variant ID Type Subtype PubMed ID
nsv509418 CNV insertion 20534489
nsv526181 CNV gain 19592680

Variation tolerance for SPDYC Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPDYC Gene

Human Gene Mutation Database (HGMD)
SPDYC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYC

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPDYC Gene

Disorders for SPDYC Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPDYC Gene - From: COP

Disorder Aliases PubMed IDs
phosphoglycerate kinase 1 deficiency
  • pgk1 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search SPDYC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPDYC

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SPDYC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPDYC Gene

Publications for SPDYC Gene

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PMID: 15611625) Cheng A … Solomon MJ (Cell cycle (Georgetown, Tex.) 2005) 2 3 4
  2. RINGO C is required to sustain the spindle-assembly checkpoint. (PMID: 20605920) Mourón S … Nebreda AR (Journal of cell science 2010) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Speedy/Ringo C regulates S and G2 phase progression in human cells. (PMID: 18802405) Cheng A … Solomon MJ (Cell cycle (Georgetown, Tex.) 2008) 3

ExternalLinks

View latest publications for SPDYC gene in Mastermind

Products for SPDYC Gene

Sources for SPDYC Gene