Aliases for SPDYA Gene
External Ids for SPDYA Gene
Previous HGNC Symbols for SPDYA Gene
Previous GeneCards Identifiers for SPDYA Gene
GeneCards Summary for SPDYA Gene
SPDYA (Speedy/RINGO Cell Cycle Regulator Family Member A) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYC.
UniProtKB/Swiss-Prot Summary for SPDYA Gene
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).