Aliases for SPDL1 Gene
External Ids for SPDL1 Gene
Previous HGNC Symbols for SPDL1 Gene
Previous GeneCards Identifiers for SPDL1 Gene
This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]
GeneCards Summary for SPDL1 Gene
SPDL1 (Spindle Apparatus Coiled-Coil Protein 1) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include enzyme binding and kinetochore binding. An important paralog of this gene is BICDL1.
UniProtKB/Swiss-Prot Summary for SPDL1 Gene
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).