Aliases for SPC25 Gene
External Ids for SPC25 Gene
Previous HGNC Symbols for SPC25 Gene
Previous GeneCards Identifiers for SPC25 Gene
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for SPC25 Gene
SPC25 (SPC25 Component Of NDC80 Kinetochore Complex) is a Protein Coding gene. Diseases associated with SPC25 include Diffuse Idiopathic Skeletal Hyperostosis. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.
UniProtKB/Swiss-Prot Summary for SPC25 Gene
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).