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Aliases for SPC25 Gene

Aliases for SPC25 Gene

  • SPC25, NDC80 Kinetochore Complex Component 2 3 5
  • SPBC25 3 4
  • HSpc25 3 4
  • SPC25, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • Spindle Pole Body Component 25 Homolog (S. Cerevisiae) 2
  • SPC25, NDC80 Kinetochore Complex Component, Homolog 3
  • Spindle Pole Body Component 25 Homolog 3
  • Kinetochore Protein Spc25 3
  • 2600017H08Rik 3
  • AD024 3

External Ids for SPC25 Gene

Previous HGNC Symbols for SPC25 Gene

  • SPBC25

Previous GeneCards Identifiers for SPC25 Gene

  • GC02M169436
  • GC02M169690
  • GC02M161623

Summaries for SPC25 Gene

Entrez Gene Summary for SPC25 Gene

  • This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPC25 Gene

SPC25 (SPC25, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for SPC25 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Additional gene information for SPC25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPC25 Gene

Genomics for SPC25 Gene

GeneHancer (GH) Regulatory Elements for SPC25 Gene

Promoters and enhancers for SPC25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I168889 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.3 +23.1 23112 1.7 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF143 SPC25 PPIG PHOSPHO2 G6PC2 GC02P168847
GH02I168913 Promoter 0.7 Ensembl 550.8 +0.1 70 0.2 POLR2A ZBTB33 CHAMP1 SPC25 G6PC2
GH02I168935 Enhancer 1.2 Ensembl ENCODE 12.2 -23.0 -23047 1.5 PKNOX1 SMAD1 ARNT ZNF766 CBX5 E2F8 REST ZNF592 MEF2D SMARCA4 SPC25 G6PC2 NOSTRIN ABCB11
GH02I168781 Enhancer 0.5 ENCODE 10.3 +132.0 132005 0.2 ATF4 CEBPB CHD4 ZBTB33 CEBPG SPC25 CERS6-AS1 NOSTRIN GC02M168607 RNU6-766P
GH02I168908 Enhancer 0.7 ENCODE 0.8 +4.9 4895 0.2 BCOR HDAC1 ATF1 TEAD4 TAL1 ZMYM3 ZIC2 TCF12 CTBP1 FOXK2 SPC25 G6PC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPC25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPC25 gene promoter:

Genomic Locations for SPC25 Gene

Genomic Locations for SPC25 Gene
chr2:168,834,132-168,913,371
(GRCh38/hg38)
Size:
79,240 bases
Orientation:
Minus strand
chr2:169,690,642-169,769,881
(GRCh37/hg19)

Genomic View for SPC25 Gene

Genes around SPC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPC25 Gene

Proteins for SPC25 Gene

  • Protein details for SPC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBM1-SPC25_HUMAN
    Recommended name:
    Kinetochore protein Spc25
    Protein Accession:
    Q9HBM1
    Secondary Accessions:
    • A8K4X8
    • D3DPC0

    Protein attributes for SPC25 Gene

    Size:
    224 amino acids
    Molecular mass:
    26153 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end.

    Three dimensional structures from OCA and Proteopedia for SPC25 Gene

neXtProt entry for SPC25 Gene

Post-translational modifications for SPC25 Gene

Other Protein References for SPC25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPC25 Gene

Domains & Families for SPC25 Gene

Gene Families for SPC25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPC25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPC25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBM1

UniProtKB/Swiss-Prot:

SPC25_HUMAN :
  • Belongs to the SPC25 family.
Family:
  • Belongs to the SPC25 family.
genes like me logo Genes that share domains with SPC25: view

Function for SPC25 Gene

Molecular function for SPC25 Gene

UniProtKB/Swiss-Prot Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Phenotypes From GWAS Catalog for SPC25 Gene

Gene Ontology (GO) - Molecular Function for SPC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14699129
genes like me logo Genes that share ontologies with SPC25: view
genes like me logo Genes that share phenotypes with SPC25: view

Animal Model Products

miRNA for SPC25 Gene

miRTarBase miRNAs that target SPC25

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPC25 Gene

Localization for SPC25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPC25 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14738735). Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). {ECO:0000269 PubMed:14699129, ECO:0000269 PubMed:14738735}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPC25 gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA,IDA 14699129
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SPC25: view

Pathways & Interactions for SPC25 Gene

genes like me logo Genes that share pathways with SPC25: view

Pathways by source for SPC25 Gene

Gene Ontology (GO) - Biological Process for SPC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization IMP 14699129
GO:0007059 chromosome segregation IMP 14699129
GO:0007062 sister chromatid cohesion TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SPC25: view

No data available for SIGNOR curated interactions for SPC25 Gene

Drugs & Compounds for SPC25 Gene

No Compound Related Data Available

Transcripts for SPC25 Gene

Unigene Clusters for SPC25 Gene

SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPC25 Gene

No ASD Table

Relevant External Links for SPC25 Gene

GeneLoc Exon Structure for
SPC25
ECgene alternative splicing isoforms for
SPC25

Expression for SPC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPC25 Gene

This gene is overexpressed in Bone (50.4) and NK cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPC25 Gene



Protein tissue co-expression partners for SPC25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPC25 Gene:

SPC25

SOURCE GeneReport for Unigene cluster for SPC25 Gene:

Hs.421956

Evidence on tissue expression from TISSUES for SPC25 Gene

  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with SPC25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPC25 Gene

Orthologs for SPC25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPC25 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia SPC25 33 34
  • 91.67 (n)
dog
(Canis familiaris)
Mammalia SPC25 33 34
  • 88.39 (n)
rat
(Rattus norvegicus)
Mammalia Spc25 33
  • 81.7 (n)
mouse
(Mus musculus)
Mammalia Spc25 33 16 34
  • 80.95 (n)
oppossum
(Monodelphis domestica)
Mammalia SPC25 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPC25 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPC25 33 34
  • 62.16 (n)
lizard
(Anolis carolinensis)
Reptilia SPC25 34
  • 29 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spc25 33
  • 57.1 (n)
zebrafish
(Danio rerio)
Actinopterygii spc25 33 34
  • 52.44 (n)
Species where no ortholog for SPC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPC25 Gene

ENSEMBL:
Gene Tree for SPC25 (if available)
TreeFam:
Gene Tree for SPC25 (if available)

Paralogs for SPC25 Gene

No data available for Paralogs for SPC25 Gene

Variants for SPC25 Gene

Sequence variations from dbSNP and Humsavar for SPC25 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000128698 -- 168,880,277(-) G/A intron_variant
rs1000132080 -- 168,888,744(-) TGTATGT/TGT intron_variant
rs1000431673 -- 168,890,547(-) AAAA/AAA upstream_transcript_variant
rs1000480806 -- 168,885,841(-) G/T intron_variant
rs1000607418 -- 168,885,852(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPC25 Gene

Variant ID Type Subtype PubMed ID
esv999271 CNV insertion 20482838
nsv227 CNV insertion 15895083
nsv3023 CNV insertion 18451855
nsv480397 CNV novel sequence insertion 20440878
nsv583599 CNV gain 21841781

Variation tolerance for SPC25 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPC25 Gene

Disorders for SPC25 Gene

Additional Disease Information for SPC25

No disorders were found for SPC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPC25 Gene

Publications for SPC25 Gene

  1. Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. (PMID: 15961401) Ciferri C … Musacchio A (The Journal of biological chemistry 2005) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of two novel components of the human NDC80 kinetochore complex. (PMID: 14699129) Bharadwaj R … Yu H (The Journal of biological chemistry 2004) 3 4 58
  5. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. (PMID: 14738735) McCleland ML … Stukenberg PT (Current biology : CB 2004) 3 4 58

Products for SPC25 Gene

Sources for SPC25 Gene

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