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Aliases for SPATS2 Gene

Aliases for SPATS2 Gene

  • Spermatogenesis Associated Serine Rich 2 2 3 5
  • Serine-Rich Spermatocytes And Round Spermatid 59 KDa Protein 3 4
  • SPATA10 3 4
  • P59SCR 3 4
  • SCR59 3 4
  • Serine-Rich Spermatocytes And Round Spermatid Protein 3
  • Spermatogenesis-Associated Serine-Rich Protein 2 3
  • Spermatogenesis Associated, Serine-Rich 2 2
  • Putative Protein Product Of Nbla00526 3
  • Nbla00526 3

External Ids for SPATS2 Gene

Previous GeneCards Identifiers for SPATS2 Gene

  • GC12P049477
  • GC12P048047
  • GC12P049760
  • GC12P046791

Summaries for SPATS2 Gene

GeneCards Summary for SPATS2 Gene

SPATS2 (Spermatogenesis Associated Serine Rich 2) is a Protein Coding gene. An important paralog of this gene is SPATS2L.

Additional gene information for SPATS2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATS2 Gene

Genomics for SPATS2 Gene

GeneHancer (GH) Regulatory Elements for SPATS2 Gene

Promoters and enhancers for SPATS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I049364 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 559.9 +1.0 1048 5.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 SPATS2 DDX23 CCNT1 KMT2D LMBR1L SMARCD1 LOC390314 TUBA1A KANSL2 KCNH3
GH12I049129 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.3 -235.2 -235217 4.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000200309 GC12M049133 TUBA1B DDX23 LMBR1L KMT2D SMARCD1 LOC390314 BCDIN3D CCNT1
GH12I050056 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 18.2 +691.0 690980 1.3 ZNF493 ZNF133 ARID4B SIN3A GLI4 ZNF2 GLIS2 ZNF213 ZNF302 ZNF416 ASIC1 KMT2D SMARCD1 LMBR1L LIMA1 ATF1 BCDIN3D LOC101927267 LOC100422296 PRPF40B
GH12I049055 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -308.1 -308081 6.7 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GC12P049057 DDX23 LOC390314 LMBR1L CCNT1 KANSL2 KMT2D LOC100422296 SENP1 PRPF40B
GH12I050217 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 14.6 +854.6 854581 8 HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT NEUROD1 SIN3A FEZF1 ZNF2 IRF4 ENSG00000257256 LIMA1 SMARCD1 CERS5 SPATS2 ATF1 LOC101927267 PRPF40B ENSG00000257531 GC12M050135
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATS2 gene promoter:

Genomic Locations for SPATS2 Gene

Genomic Locations for SPATS2 Gene
chr12:49,366,584-49,527,426
(GRCh38/hg38)
Size:
160,843 bases
Orientation:
Plus strand
chr12:49,760,367-49,921,207
(GRCh37/hg19)

Genomic View for SPATS2 Gene

Genes around SPATS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATS2 Gene

Proteins for SPATS2 Gene

  • Protein details for SPATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XZ4-SPAS2_HUMAN
    Recommended name:
    Spermatogenesis-associated serine-rich protein 2
    Protein Accession:
    Q86XZ4
    Secondary Accessions:
    • A8K8G9
    • Q9H7D4
    • Q9H8Y7
    • Q9H8Z8

    Protein attributes for SPATS2 Gene

    Size:
    545 amino acids
    Molecular mass:
    59545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14448.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14958.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPATS2 Gene

Post-translational modifications for SPATS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATS2 Gene

Domains & Families for SPATS2 Gene

Gene Families for SPATS2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XZ4

UniProtKB/Swiss-Prot:

SPAS2_HUMAN :
  • Belongs to the SPATS2 family.
Family:
  • Belongs to the SPATS2 family.
genes like me logo Genes that share domains with SPATS2: view

Function for SPATS2 Gene

Phenotypes From GWAS Catalog for SPATS2 Gene

Gene Ontology (GO) - Molecular Function for SPATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with SPATS2: view
genes like me logo Genes that share phenotypes with SPATS2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATS2 Gene

Localization for SPATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATS2 gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SPATS2: view

Pathways & Interactions for SPATS2 Gene

SuperPathways for SPATS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATS2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATS2 Gene

Drugs & Compounds for SPATS2 Gene

No Compound Related Data Available

Transcripts for SPATS2 Gene

Unigene Clusters for SPATS2 Gene

Spermatogenesis associated, serine-rich 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - -
SP15: - - - - - -
SP16: - - - - - -
SP17: - - - - - -
SP18:
SP19: - - - -

ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:

Relevant External Links for SPATS2 Gene

GeneLoc Exon Structure for
SPATS2
ECgene alternative splicing isoforms for
SPATS2

Expression for SPATS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATS2 Gene

This gene is overexpressed in Lung (56.8) and Bone (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPATS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPATS2 Gene:

SPATS2

SOURCE GeneReport for Unigene cluster for SPATS2 Gene:

Hs.654826

Evidence on tissue expression from TISSUES for SPATS2 Gene

  • Liver(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SPATS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATS2 Gene

Orthologs for SPATS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATS2 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia SPATS2 33 34
  • 91.93 (n)
cow
(Bos Taurus)
Mammalia SPATS2 33
  • 90.03 (n)
-- 34
  • 88 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Spats2 33 16 34
  • 83.64 (n)
rat
(Rattus norvegicus)
Mammalia Spats2 33
  • 82.9 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATS2 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATS2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATS2 33 34
  • 69.04 (n)
lizard
(Anolis carolinensis)
Reptilia SPATS2 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spats2 33
  • 62.19 (n)
MGC75583 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69117 33
zebrafish
(Danio rerio)
Actinopterygii zgc:154064 33
  • 57.29 (n)
SPATS2 (1 of 2) 34
  • 46 (a)
OneToMany
SPATS2 (2 of 2) 34
  • 42 (a)
OneToMany
hcrtr2 33
Species where no ortholog for SPATS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATS2 Gene

ENSEMBL:
Gene Tree for SPATS2 (if available)
TreeFam:
Gene Tree for SPATS2 (if available)

Paralogs for SPATS2 Gene

Paralogs for SPATS2 Gene

genes like me logo Genes that share paralogs with SPATS2: view

Variants for SPATS2 Gene

Sequence variations from dbSNP and Humsavar for SPATS2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000002453 -- 49,503,778(+) C/G intron_variant
rs1000011751 -- 49,460,027(+) G/A/T intron_variant
rs1000020958 -- 49,447,454(+) G/A intron_variant
rs1000029116 -- 49,496,376(+) T/C intron_variant
rs1000033868 -- 49,503,210(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATS2 Gene

Variant ID Type Subtype PubMed ID
dgv1497n100 CNV gain 25217958
esv1526240 CNV deletion 17803354
esv2660035 CNV deletion 23128226
esv2665539 CNV deletion 23128226
esv2674904 CNV deletion 23128226
esv2675557 CNV deletion 23128226
esv2678939 CNV deletion 23128226
esv3549186 CNV deletion 23714750
esv3580270 CNV loss 25503493
esv3629458 CNV loss 21293372
esv3629460 CNV loss 21293372
esv3629461 CNV loss 21293372
esv3629462 CNV loss 21293372
esv3629463 CNV loss 21293372
esv3629464 CNV loss 21293372
nsv1134228 CNV deletion 24896259
nsv518746 CNV loss 19592680
nsv832405 CNV gain 17160897
nsv832406 CNV loss 17160897

Variation tolerance for SPATS2 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATS2 Gene

Disorders for SPATS2 Gene

Additional Disease Information for SPATS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPATS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATS2 Gene

Publications for SPATS2 Gene

  1. Microarray analysis of bisphenol A-induced changes in gene expression in human oral epithelial cells. (PMID: 17989879) Seki K … Ito K (Acta biochimica et biophysica Sinica 2007) 2 3 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification of a novel protein p59(scr), which is expressed at specific stages of mouse spermatogenesis. (PMID: 11944913) Senoo M … Habu S (Biochemical and biophysical research communications 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SPATS2 Gene

Sources for SPATS2 Gene

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