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Aliases for SPATS1 Gene

Aliases for SPATS1 Gene

  • Spermatogenesis Associated Serine Rich 1 2 3 5
  • Spermatogenesis-Associated Serine-Rich Protein 1 3
  • Spermatogenesis Associated, Serine-Rich 1 2
  • SPATA8 3
  • SRSP1 3
  • DDIP 3

External Ids for SPATS1 Gene

Previous GeneCards Identifiers for SPATS1 Gene

  • GC06P044311
  • GC06P044358
  • GC06P044359
  • GC06P044418
  • GC06P044033

Summaries for SPATS1 Gene

GeneCards Summary for SPATS1 Gene

SPATS1 (Spermatogenesis Associated Serine Rich 1) is a Protein Coding gene.

Additional gene information for SPATS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATS1 Gene

Genomics for SPATS1 Gene

GeneHancer (GH) Regulatory Elements for SPATS1 Gene

Promoters and enhancers for SPATS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I044342 Promoter/Enhancer 1.1 EPDnew Ensembl 556.9 0.0 -18 1.1 TEAD4 TAL1 NRF1 CEBPB CBFA2T3 CEBPG TCF12 CBFA2T2 RCOR1 CHD2 SPATS1 TMEM151B NFKBIE AARS2 SLC35B2 CDC5L GC06M044325 ENSG00000272442
GH06I044071 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -268.1 -268120 6.6 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B ZNF2 YY1 ENSG00000231881 GC06M044069 LOC101929705 ZNF318 GTPBP2 POLH ABCC10 VEGFA RPS2P29 RPL34P14
GH06I044236 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -104.8 -104756 2.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 GC06P044236 NFKBIE CAPN11 MRPL14 TMEM63B AARS2 SPATS1 RPL34P14 HSP90AB1 SLC29A1
GH06I044079 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.8 -263.3 -263333 0.3 ARID4B SIN3A ZNF766 ARID2 ZNF143 ATF7 RUNX3 ZNF263 SP3 NCOA1 VEGFA SPATS1 LOC101929705 GC06M044090
GH06I044094 Enhancer 0.9 ENCODE 9.7 -247.8 -247752 1.8 PKNOX1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 RXRA SP5 MRPL14 TMEM63B CAPN11 VEGFA AARS2 SLC29A1 HSP90AB1 SLC35B2 NFKBIE TMEM151B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATS1 gene promoter:

Genomic Locations for SPATS1 Gene

Genomic Locations for SPATS1 Gene
chr6:44,342,660-44,377,167
(GRCh38/hg38)
Size:
34,508 bases
Orientation:
Plus strand
chr6:44,310,397-44,344,904
(GRCh37/hg19)

Genomic View for SPATS1 Gene

Genes around SPATS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATS1 Gene

Proteins for SPATS1 Gene

  • Protein details for SPATS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496A3-SPAS1_HUMAN
    Recommended name:
    Spermatogenesis-associated serine-rich protein 1
    Protein Accession:
    Q496A3
    Secondary Accessions:
    • Q496A2
    • Q496A5
    • Q96LJ0

    Protein attributes for SPATS1 Gene

    Size:
    300 amino acids
    Molecular mass:
    33705 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATS1 Gene

Post-translational modifications for SPATS1 Gene

No Post-translational modifications

Other Protein References for SPATS1 Gene

No data available for DME Specific Peptides for SPATS1 Gene

Domains & Families for SPATS1 Gene

Gene Families for SPATS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATS1: view

No data available for UniProtKB/Swiss-Prot for SPATS1 Gene

Function for SPATS1 Gene

Phenotypes From GWAS Catalog for SPATS1 Gene

genes like me logo Genes that share phenotypes with SPATS1: view

Animal Models for SPATS1 Gene

MGI Knock Outs for SPATS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPATS1 Gene

Localization for SPATS1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPATS1 Gene

Pathways & Interactions for SPATS1 Gene

SuperPathways for SPATS1 Gene

No Data Available

Interacting Proteins for SPATS1 Gene

Selected Interacting proteins: Q496A3-SPAS1_HUMAN for SPATS1 Gene via IID

Gene Ontology (GO) - Biological Process for SPATS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATS1 Gene

Drugs & Compounds for SPATS1 Gene

No Compound Related Data Available

Transcripts for SPATS1 Gene

mRNA/cDNA for SPATS1 Gene

Unigene Clusters for SPATS1 Gene

Spermatogenesis associated, serine-rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATS1 Gene

No ASD Table

Relevant External Links for SPATS1 Gene

GeneLoc Exon Structure for
SPATS1
ECgene alternative splicing isoforms for
SPATS1

Expression for SPATS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATS1 Gene

mRNA differential expression in normal tissues according to GTEx for SPATS1 Gene

This gene is overexpressed in Testis (x42.3).

NURSA nuclear receptor signaling pathways regulating expression of SPATS1 Gene:

SPATS1

SOURCE GeneReport for Unigene cluster for SPATS1 Gene:

Hs.135283
genes like me logo Genes that share expression patterns with SPATS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATS1 Gene

Orthologs for SPATS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATS1 33 34
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia SPATS1 33 34
  • 85.83 (n)
cow
(Bos Taurus)
Mammalia SPATS1 33
  • 82.6 (n)
mouse
(Mus musculus)
Mammalia Spats1 33 16 34
  • 76.49 (n)
rat
(Rattus norvegicus)
Mammalia Spats1 33
  • 75.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPATS1 34
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATS1 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497327 33
  • 51.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToOne
Species where no ortholog for SPATS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATS1 Gene

ENSEMBL:
Gene Tree for SPATS1 (if available)
TreeFam:
Gene Tree for SPATS1 (if available)

Paralogs for SPATS1 Gene

No data available for Paralogs for SPATS1 Gene

Variants for SPATS1 Gene

Sequence variations from dbSNP and Humsavar for SPATS1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000149848 -- 44,358,026(+) G/A intron_variant
rs1000260377 -- 44,375,876(+) C/T intron_variant
rs1000345054 -- 44,345,439(+) C/T intron_variant
rs1000365964 -- 44,342,996(+) G/A intron_variant
rs1000446251 -- 44,366,820(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATS1 Gene

Variant ID Type Subtype PubMed ID
nsv1019145 CNV gain 25217958
esv3608829 CNV loss 21293372
esv3608828 CNV loss 21293372
esv3608827 CNV loss 21293372
esv3567728 CNV deletion 23714750
esv2656645 CNV deletion 23128226

Variation tolerance for SPATS1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATS1 Gene

Disorders for SPATS1 Gene

Additional Disease Information for SPATS1

No disorders were found for SPATS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATS1 Gene

Publications for SPATS1 Gene

  1. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  2. Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex. (PMID: 20603214) Zhang H … Chang Z (Cellular signalling 2010) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SPATS1 Gene

Sources for SPATS1 Gene

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