Aliases for SPATA9 Gene

Aliases for SPATA9 Gene

  • Spermatogenesis Associated 9 2 3 5
  • Spermatogenesis-Associated Protein 9 3 4
  • Testis Development Protein NYD-SP16 3 4
  • NYD-SP16 2 3
  • Testicular Tissue Protein Li 179 3
  • CTD-2154I11.2 3
  • FLJ35906 2
  • SPATA9 5

External Ids for SPATA9 Gene

Previous GeneCards Identifiers for SPATA9 Gene

  • GC05M095016
  • GC05M095061
  • GC05M095013
  • GC05M090184

Summaries for SPATA9 Gene

GeneCards Summary for SPATA9 Gene

SPATA9 (Spermatogenesis Associated 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SPATA9 Gene

  • May play a role in testicular development/spermatogenesis and may be an important factor in male infertility.

Additional gene information for SPATA9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA9 Gene

Genomics for SPATA9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA9

Top Transcription factor binding sites by QIAGEN in the SPATA9 gene promoter:
  • AREB6
  • HOXA3

Genomic Locations for SPATA9 Gene

Genomic Locations for SPATA9 Gene
chr5:95,652,181-95,732,102
(GRCh38/hg38)
Size:
79,922 bases
Orientation:
Minus strand
chr5:94,987,885-95,034,415
(GRCh37/hg19)
Size:
46,531 bases
Orientation:
Minus strand

Genomic View for SPATA9 Gene

Genes around SPATA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA9 Gene

Proteins for SPATA9 Gene

  • Protein details for SPATA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWV2-SPAT9_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 9
    Protein Accession:
    Q9BWV2
    Secondary Accessions:
    • A8K8H3
    • Q4G122
    • Q86X33
    • Q8NA28

    Protein attributes for SPATA9 Gene

    Size:
    254 amino acids
    Molecular mass:
    28740 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for SPATA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA9 Gene

Post-translational modifications for SPATA9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA9 Gene

Domains & Families for SPATA9 Gene

Gene Families for SPATA9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPATA9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA9 Gene

GenScript: Design optimal peptide antigens:
  • Testis development protein NYD-SP16 (SPAT9_HUMAN)
genes like me logo Genes that share domains with SPATA9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA9 Gene

Function for SPATA9 Gene

Molecular function for SPATA9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in testicular development/spermatogenesis and may be an important factor in male infertility.

Phenotypes From GWAS Catalog for SPATA9 Gene

Gene Ontology (GO) - Molecular Function for SPATA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPATA9: view
genes like me logo Genes that share phenotypes with SPATA9: view

Animal Models for SPATA9 Gene

MGI Knock Outs for SPATA9:

Animal Model Products

CRISPR Products

miRNA for SPATA9 Gene

miRTarBase miRNAs that target SPATA9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPATA9 Gene

Localization for SPATA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA9 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA9 gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1
golgi apparatus 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPATA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPATA9: view

Pathways & Interactions for SPATA9 Gene

PathCards logo

SuperPathways for SPATA9 Gene

No Data Available

Interacting Proteins for SPATA9 Gene

Gene Ontology (GO) - Biological Process for SPATA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA9: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA9 Gene

Drugs & Compounds for SPATA9 Gene

No Compound Related Data Available

Transcripts for SPATA9 Gene

mRNA/cDNA for SPATA9 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA9

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SPATA9 Gene

GeneLoc Exon Structure for
SPATA9

Expression for SPATA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SPATA9 Gene

This gene is overexpressed in Testis (x24.1).

Protein differential expression in normal tissues from HIPED for SPATA9 Gene

This gene is overexpressed in Plasma (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA9 Gene



Protein tissue co-expression partners for SPATA9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA9

SOURCE GeneReport for Unigene cluster for SPATA9 Gene:

Hs.50499

mRNA Expression by UniProt/SwissProt for SPATA9 Gene:

Q9BWV2-SPAT9_HUMAN
Tissue specificity: Highly expressed in testes and pancreas. Low levels found in the heart, lungs, and brain. Very low expression detected in the placenta. No expression seen in skeletal muscle, liver, kidney, thymus, small intestine, colons, spleen, leukocytes, prostate gland, and ovary. In the adult testes, expression was about 6.44-fold higher than in the embryo testes. No expression in testes of patients with Sertoli-cell-only syndrome. In patients with arrest at spermatogonium and primary spermatocyte stages, no expression was detected. In patients with arrest at the spermatid stage, expression level was weak or absent. Variable expression was seen in patients with spermatogenic arrest.

Evidence on tissue expression from TISSUES for SPATA9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPATA9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA9 Gene

Orthologs for SPATA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPATA9 30 31
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPATA9 30 31
  • 90.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPATA9 30 31
  • 89.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spata9 30
  • 85.39 (n)
Mouse
(Mus musculus)
Mammalia Spata9 30 17 31
  • 82.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SPATA9 31
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SPATA9 31
  • 39 (a)
OneToOne
Species where no ortholog for SPATA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPATA9 Gene

ENSEMBL:
Gene Tree for SPATA9 (if available)
TreeFam:
Gene Tree for SPATA9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA9: view image

Paralogs for SPATA9 Gene

No data available for Paralogs for SPATA9 Gene

Variants for SPATA9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA9 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs34297786 - p.Lys209Glu

Additional dbSNP identifiers (rs#s) for SPATA9 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA9 Gene

Variant ID Type Subtype PubMed ID
esv1052640 CNV insertion 17803354
esv2513210 CNV insertion 19546169
esv3303585 CNV mobile element insertion 20981092
esv3309189 CNV mobile element insertion 20981092
esv3349666 CNV insertion 20981092
esv3388266 CNV insertion 20981092
esv3403924 CNV insertion 20981092
nsv507274 OTHER sequence alteration 20534489
nsv598955 CNV gain 21841781
nsv598960 CNV loss 21841781
nsv830409 CNV gain 17160897

Variation tolerance for SPATA9 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 50.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA9 Gene

Disorders for SPATA9 Gene

Additional Disease Information for SPATA9

No disorders were found for SPATA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA9 Gene

Publications for SPATA9 Gene

  1. NYD-SP16, a novel gene associated with spermatogenesis of human testis. (PMID: 12493713) Cheng LJ … Sha JH (Biology of reproduction 2003) 2 3 4
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. (PMID: 30745168) Wang B … Liu Y (EBioMedicine 2019) 3

Products for SPATA9 Gene

  • Signalway ELISA kits for SPATA9

Sources for SPATA9 Gene