Aliases for SPATA8 Gene

Subcategory (RNA class) for SPATA8 Gene

lncRNA

Number of RNA Genes sources:

2 / 17

Aliases for SPATA8 Gene

  • Spermatogenesis Associated 8 2 3 5
  • Spermatogenesis-Associated Protein 8 3 4
  • Spermatogenesis-Related Protein 8 3 4
  • Testicular Secretory Protein Li 52 3
  • NONHSAG018020.2 91
  • HSALNG0108424 164
  • MGC44294 2
  • SPATA8 5
  • SRG8 3

External Ids for SPATA8 Gene

Previous GeneCards Identifiers for SPATA8 Gene

  • GC15P095128
  • GC15P097326
  • GC15P073456

Summaries for SPATA8 Gene

GeneCards Summary for SPATA8 Gene

SPATA8 (Spermatogenesis Associated 8) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with SPATA8 include Failure Of Tooth Eruption, Primary.

Additional gene information for SPATA8 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA8 Gene

Genomics for SPATA8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J096783 Promoter 0.3 EPDnew 600.7 +0.1 62 0.1 SPATA8 SPATA8-AS1 piR-30528 piR-33058 piR-37001 piR-38881 piR-33772 piR-37693 piR-34012 piR-38019
GH15J096784 Promoter 0.3 EPDnew 600.7 0.0 -41 0.1 SPATA8 SPATA8-AS1 piR-30528 piR-33058 piR-37001 piR-38881 piR-33772 piR-37693 piR-34012 piR-38019
GH15J096775 Promoter 0.3 EPDnew 600.4 -7.8 -7846 0.1 piR-36116 piR-32865 piR-36501 piR-37333 piR-38885 piR-39070 piR-37831 piR-39582 piR-39657 piR-34596
GH15J096782 Enhancer 0.3 FANTOM5 609.6 -0.8 -794 0.4 ZNF680 SPATA8 SPATA8-AS1 piR-35772 piR-30528 piR-33058 piR-31097 piR-37001 piR-33612 piR-38796 piR-38881
GH15J096891 Enhancer 0.7 UCNEbase ENCODE 10.2 +107.9 107947 0.3 EZH2 NANOG SPATA8 piR-36756-029 piR-32559-149 lnc-SPATA8-4 NR2F2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA8

Top Transcription factor binding sites by QIAGEN in the SPATA8 gene promoter:
  • AML1a
  • AREB6
  • GR
  • GR-alpha
  • GR-beta
  • HTF
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1

Genomic Locations for SPATA8 Gene

Genomic Locations for SPATA8 Gene
chr15:96,783,389-96,785,615
(GRCh38/hg38)
Size:
2,227 bases
Orientation:
Plus strand
chr15:97,326,619-97,328,845
(GRCh37/hg19)
Size:
2,227 bases
Orientation:
Plus strand

Genomic View for SPATA8 Gene

Genes around SPATA8 on UCSC Golden Path with GeneCards custom track
SPATA8 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
SPATA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA8 Gene

Proteins for SPATA8 Gene

  • Protein details for SPATA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RVD6-SPAT8_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 8
    Protein Accession:
    Q6RVD6
    Secondary Accessions:
    • Q2KJ07

    Protein attributes for SPATA8 Gene

    Size:
    105 amino acids
    Molecular mass:
    11727 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA8 Gene

Post-translational modifications for SPATA8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA8 Gene

Domains & Families for SPATA8 Gene

Gene Families for SPATA8 Gene

Protein Domains for SPATA8 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPATA8 Gene

GenScript: Design optimal peptide antigens:
  • Spermatogenesis-related protein 8 (SPAT8_HUMAN)
genes like me logo Genes that share domains with SPATA8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA8 Gene

Function for SPATA8 Gene

Phenotypes From GWAS Catalog for SPATA8 Gene

Gene Ontology (GO) - Molecular Function for SPATA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SPATA8: view
genes like me logo Genes that share phenotypes with SPATA8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA8 Gene

Localization for SPATA8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA8 gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPATA8 Gene

Pathways & Interactions for SPATA8 Gene

PathCards logo

SuperPathways for SPATA8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA8 Gene

Drugs & Compounds for SPATA8 Gene

No Compound Related Data Available

Transcripts for SPATA8 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for SPATA8 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000D7809D_9606 lncRNA 882 2

HGNC: 28676,

RefSeq: NR_158223,

URS0000EEC10B_9606 lncRNA 1436 1

Ensembl: ENST00000671619 (view in UCSC) ,

URS0000EF53C5_9606 lncRNA 1115 1

Ensembl: ENST00000561002 (view in UCSC) ,

URS0000DB8B54_9606 lncRNA 1083 1

Ensembl: ENST00000649986 (view in UCSC) ,

URS0000D780B9_9606 lncRNA 1037 1

RefSeq: NR_158220,

SPATA8 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for SPATA8 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA8

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -

Relevant External Links for SPATA8 Gene

GeneLoc Exon Structure for
SPATA8

Expression for SPATA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SPATA8 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for SPATA8 Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA8 Gene



Protein tissue co-expression partners for SPATA8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA8

SOURCE GeneReport for Unigene cluster for SPATA8 Gene:

Hs.326528

mRNA Expression by UniProt/SwissProt for SPATA8 Gene:

Q6RVD6-SPAT8_HUMAN
Tissue specificity: Expressed at high levels in adult testis, at moderate levels in sperm and at low levels in fetal testis. Not detected in other tissues.
genes like me logo Genes that share expression patterns with SPATA8: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA8 Gene

Orthologs for SPATA8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPATA8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPATA8 30 31
  • 99.37 (n)
OneToOne
Species where no ortholog for SPATA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPATA8 Gene

ENSEMBL:
Gene Tree for SPATA8 (if available)
TreeFam:
Gene Tree for SPATA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA8: view image

Paralogs for SPATA8 Gene

No data available for Paralogs for SPATA8 Gene

Variants for SPATA8 Gene

Additional dbSNP identifiers (rs#s) for SPATA8 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA8 Gene

Variant ID Type Subtype PubMed ID
esv3892734 CNV loss 25118596
nsv522924 CNV gain 19592680

Variation tolerance for SPATA8 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA8 Gene

Human Gene Mutation Database (HGMD)
SPATA8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA8 Gene

Disorders for SPATA8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPATA8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
failure of tooth eruption, primary
  • pfe
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPATA8

genes like me logo Genes that share disorders with SPATA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA8 Gene

Publications for SPATA8 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41
  2. Molecular cloning and characterization of a novel human testis-specific gene by use of digital differential display. (PMID: 16809841) Nie D … Xiang Y (Journal of genetics 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for SPATA8 Gene

  • Signalway ELISA kits for SPATA8

Sources for SPATA8 Gene