Aliases for SPATA4 Gene

Aliases for SPATA4 Gene

  • Spermatogenesis Associated 4 2 3 5
  • Testis Spermatocyte Apoptosis-Related Gene 2 Protein 3 4
  • Spermatogenesis-Associated Protein 4 3 4
  • TSARG2 3 4
  • Testis And Spermatogenesis Cell Related Protein 2 3
  • Testis And Spermatogenesis Cell-Related Protein 2 4
  • SPEF1B 3

External Ids for SPATA4 Gene

Previous GeneCards Identifiers for SPATA4 Gene

  • GC00U991162
  • GC04M177802
  • GC04M177480
  • GC04M177342
  • GC04M177105
  • GC04M172856

Summaries for SPATA4 Gene

GeneCards Summary for SPATA4 Gene

SPATA4 (Spermatogenesis Associated 4) is a Protein Coding gene. An important paralog of this gene is SPEF1.

UniProtKB/Swiss-Prot Summary for SPATA4 Gene

Additional gene information for SPATA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA4 Gene

Genomics for SPATA4 Gene

GeneHancer (GH) Regulatory Elements for SPATA4 Gene

Promoters and enhancers for SPATA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J176192 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.2 1229 3.9 ZNF217 EP300 SIN3A NRF1 POLR2G USF1 SP1 PHF8 JUND FOS SPATA4 lnc-WDR17-5 WDR17 RF00017-4459
GH04J176184 Enhancer 0.8 Ensembl ENCODE 12.9 +8.6 8630 4.7 FOS EP300 OSR2 CEBPB SPI1 EZH2 GTF2F1 ZNF335 MAX STAT3 SPATA4 WDR17 RF00017-4459 piR-43107-244
GH04J176654 Enhancer 0.2 FANTOM5 40.1 -458.5 -458507 0 LOC105377555 piR-45035-146 SPATA4 ENSG00000248388 lnc-VEGFC-1
GH04J176205 Enhancer 0.2 Ensembl 7 -9.9 -9930 0.8 WDR17 SPATA4 lnc-WDR17-5 piR-61945-398
GH04J176190 Enhancer 0.3 Ensembl 0.7 +5.0 4971 0.2 FOXA1 RF00017-4459 SPATA4 piR-43107-244
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA4

Top Transcription factor binding sites by QIAGEN in the SPATA4 gene promoter:
  • aMEF-2
  • AREB6
  • C/EBPalpha
  • FOXD3
  • IRF-7A
  • MEF-2A
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • ZID

Genomic Locations for SPATA4 Gene

Genomic Locations for SPATA4 Gene
chr4:176,184,574-176,195,671
(GRCh38/hg38)
Size:
11,098 bases
Orientation:
Minus strand
chr4:177,105,725-177,116,822
(GRCh37/hg19)
Size:
11,098 bases
Orientation:
Minus strand

Genomic View for SPATA4 Gene

Genes around SPATA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA4 Gene

Proteins for SPATA4 Gene

  • Protein details for SPATA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEY3-SPAT4_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 4
    Protein Accession:
    Q8NEY3
    Secondary Accessions:
    • Q8NCS5
    • Q8WW15

    Protein attributes for SPATA4 Gene

    Size:
    305 amino acids
    Molecular mass:
    34751 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA4 Gene

Post-translational modifications for SPATA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA4 Gene

Domains & Families for SPATA4 Gene

Gene Families for SPATA4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA4 Gene

Blocks:
  • Protein of unknown function DUF1042
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA4 Gene

GenScript: Design optimal peptide antigens:
  • SPATA4 protein (Q49AE5_HUMAN)
  • Testis spermatocyte apoptosis-related gene 2 protein (SPAT4_HUMAN)
genes like me logo Genes that share domains with SPATA4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA4 Gene

Function for SPATA4 Gene

Molecular function for SPATA4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis regulation.

Gene Ontology (GO) - Molecular Function for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA,IPI 25416956
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with SPATA4: view
genes like me logo Genes that share phenotypes with SPATA4: view

Animal Models for SPATA4 Gene

MGI Knock Outs for SPATA4:

Animal Model Products

CRISPR Products

miRNA for SPATA4 Gene

miRTarBase miRNAs that target SPATA4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPATA4 Gene

Localization for SPATA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA4 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005930 axoneme IBA 21873635
genes like me logo Genes that share ontologies with SPATA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPATA4 Gene

Pathways & Interactions for SPATA4 Gene

PathCards logo

SuperPathways for SPATA4 Gene

No Data Available

Interacting Proteins for SPATA4 Gene

;

Gene Ontology (GO) - Biological Process for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051493 regulation of cytoskeleton organization IBA 21873635
genes like me logo Genes that share ontologies with SPATA4: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA4 Gene

Drugs & Compounds for SPATA4 Gene

No Compound Related Data Available

Transcripts for SPATA4 Gene

mRNA/cDNA for SPATA4 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA4

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for SPATA4 Gene

GeneLoc Exon Structure for
SPATA4

Expression for SPATA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA4 Gene

This gene is overexpressed in Testis (x42.3).

Protein differential expression in normal tissues from HIPED for SPATA4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA4 Gene



Protein tissue co-expression partners for SPATA4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA4

SOURCE GeneReport for Unigene cluster for SPATA4 Gene:

Hs.481235

mRNA Expression by UniProt/SwissProt for SPATA4 Gene:

Q8NEY3-SPAT4_HUMAN
Tissue specificity: Highly expressed in testis, the expression is observed precisely in seminiferous tubules.
genes like me logo Genes that share expression patterns with SPATA4: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA4 Gene

Orthologs for SPATA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA4 31 30
  • 99.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SPATA4 31 30
  • 83.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA4 31 30
  • 83.48 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata4 30
  • 79.62 (n)
mouse
(Mus musculus)
Mammalia Spata4 17 31 30
  • 79.02 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA4 31
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA4 31
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA4 31 30
  • 53.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA4 31
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata4 30
  • 55.06 (n)
zebrafish
(Danio rerio)
Actinopterygii spata4 30
  • 55.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToOne
Species where no ortholog for SPATA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA4 Gene

ENSEMBL:
Gene Tree for SPATA4 (if available)
TreeFam:
Gene Tree for SPATA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA4: view image

Paralogs for SPATA4 Gene

Paralogs for SPATA4 Gene

genes like me logo Genes that share paralogs with SPATA4: view

Variants for SPATA4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA4 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs17062589 - p.Tyr149Cys

Additional dbSNP identifiers (rs#s) for SPATA4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA4 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV deletion 23290073
esv34137 CNV loss 18971310
esv3603274 CNV gain 21293372
nsv1017524 CNV gain 25217958
nsv1020249 CNV loss 25217958
nsv596262 CNV gain 21841781

Variation tolerance for SPATA4 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA4 Gene

Disorders for SPATA4 Gene

Additional Disease Information for SPATA4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPATA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA4 Gene

Publications for SPATA4 Gene

  1. [Rapid identification of human testis spermatocyte apoptosis-related gene, TSARG2, by nested PCR and draft human genome searching]. (PMID: 12019456) Liu SF … Lu GX (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2002) 3 4 23 54
  2. SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family Proteins in HeLa Cells. (PMID: 26424010) Jiang J … Wang Z (Biological & pharmaceutical bulletin 2015) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Cloning of a full-length cDNA of human testis-specific spermatogenic cell apoptosis inhibitor TSARG2 as a candidate oncogene. (PMID: 15158438) Liu SF … Wang Z (Biochemical and biophysical research communications 2004) 3 4 54

Products for SPATA4 Gene

Sources for SPATA4 Gene