Aliases for SPATA33 Gene

Aliases for SPATA33 Gene

  • Spermatogenesis Associated 33 2 3 5
  • Spermatogenesis-Associated Protein 33 3 4
  • C16orf55 3 4
  • Chromosome 16 Open Reading Frame 55 2
  • FLJ31606 2
  • SPATA33 5

External Ids for SPATA33 Gene

Previous HGNC Symbols for SPATA33 Gene

  • C16orf55

Previous GeneCards Identifiers for SPATA33 Gene

  • GC16P089733

Summaries for SPATA33 Gene

GeneCards Summary for SPATA33 Gene

SPATA33 (Spermatogenesis Associated 33) is a Protein Coding gene. Diseases associated with SPATA33 include Fanconi Anemia, Complementation Group A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA33 Gene

Genomics for SPATA33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA33 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA33

Genomic Locations for SPATA33 Gene

Genomic Locations for SPATA33 Gene
chr16:89,657,744-89,671,272
(GRCh38/hg38)
Size:
13,529 bases
Orientation:
Plus strand
chr16:89,724,210-89,737,680
(GRCh37/hg19)
Size:
13,471 bases
Orientation:
Plus strand

Genomic View for SPATA33 Gene

Genes around SPATA33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA33 Gene

Proteins for SPATA33 Gene

  • Protein details for SPATA33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N06-SPT33_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 33
    Protein Accession:
    Q96N06
    Secondary Accessions:
    • A8WFL2
    • B4DZN8

    Protein attributes for SPATA33 Gene

    Size:
    139 amino acids
    Molecular mass:
    15461 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA33 Gene

Post-translational modifications for SPATA33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA33 Gene

Domains & Families for SPATA33 Gene

Gene Families for SPATA33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA33 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50739 (B4DZN8_HUMAN)
  • C16orf55 protein (Q86XC3_HUMAN)
genes like me logo Genes that share domains with SPATA33: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA33 Gene

Function for SPATA33 Gene

Phenotypes From GWAS Catalog for SPATA33 Gene

genes like me logo Genes that share phenotypes with SPATA33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA33

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA33 Gene

Localization for SPATA33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA33 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA33 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SPATA33: view

Pathways & Interactions for SPATA33 Gene

PathCards logo

SuperPathways for SPATA33 Gene

No Data Available

Interacting Proteins for SPATA33 Gene

Gene Ontology (GO) - Biological Process for SPATA33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA33 Gene

Drugs & Compounds for SPATA33 Gene

No Compound Related Data Available

Transcripts for SPATA33 Gene

mRNA/cDNA for SPATA33 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA33

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - - - - -
SP11:

Relevant External Links for SPATA33 Gene

GeneLoc Exon Structure for
SPATA33

Expression for SPATA33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SPATA33 Gene

This gene is overexpressed in Testis (x13.8).

Protein differential expression in normal tissues from HIPED for SPATA33 Gene

This gene is overexpressed in Testis (49.3) and Ovary (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA33 Gene



Protein tissue co-expression partners for SPATA33 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA33

Evidence on tissue expression from TISSUES for SPATA33 Gene

  • Spleen(3)
  • Nervous system(3)
  • Lung(2.9)
  • Liver(2.8)
  • Kidney(2.6)
  • Muscle(2.6)
  • Intestine(2.6)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with SPATA33: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA33 Gene

Orthologs for SPATA33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA33 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPATA33 30 31
  • 99.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spata33 30 17 31
  • 72.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spata33 30
  • 70.77 (n)
Cow
(Bos Taurus)
Mammalia SPATA33 30
  • 67.65 (n)
Dog
(Canis familiaris)
Mammalia SPATA33 31
  • 51 (a)
OneToOne
Species where no ortholog for SPATA33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPATA33 Gene

ENSEMBL:
Gene Tree for SPATA33 (if available)
TreeFam:
Gene Tree for SPATA33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA33: view image

Paralogs for SPATA33 Gene

(1) SIMAP similar genes for SPATA33 Gene using alignment to 7 proteins:

  • SPT33_HUMAN
  • H3BQG0_HUMAN
  • H3BSG8_HUMAN
  • J3KRC8_HUMAN
  • J3KS00_HUMAN
  • J3KS58_HUMAN
  • J3KSB2_HUMAN
genes like me logo Genes that share paralogs with SPATA33: view

No data available for Paralogs for SPATA33 Gene

Variants for SPATA33 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA33 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs13329897 - p.Ser45Leu

Additional dbSNP identifiers (rs#s) for SPATA33 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA33 Gene

Variant ID Type Subtype PubMed ID
esv2762221 CNV gain+loss 21179565
nsv1057351 CNV loss 25217958
nsv1063483 CNV gain 25217958
nsv1066382 CNV gain 25217958
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv573739 CNV gain 21841781
nsv573743 CNV gain 21841781

Variation tolerance for SPATA33 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA33 Gene

Disorders for SPATA33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPATA33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanca
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SPATA33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA33 Gene

Publications for SPATA33 Gene

  1. A novel testis-enriched gene Spata33 is expressed during spermatogenesis. (PMID: 23844118) Chen H … Zhou R (PloS one 2013) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Gene alterations and expression spectrum of SPATA33 in nonobstructive azoospermic Iranian men. (PMID: 30098056) Monsef L … Mohseni Meybodi A (Molecular reproduction and development 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for SPATA33 Gene

Sources for SPATA33 Gene