Aliases for SPATA31A3 Gene

Aliases for SPATA31A3 Gene

  • SPATA31 Subfamily A Member 3 2 3 5
  • Family With Sequence Similarity 75, Member A3 2 3
  • Spermatogenesis-Associated Protein 31A3 3 4
  • Protein FAM75A3 3 4
  • FAM75A3 3 4
  • OTTHUMG00000013164 2
  • DKFZp434B204 2
  • SPATA31A3 5

External Ids for SPATA31A3 Gene

Previous HGNC Symbols for SPATA31A3 Gene

  • FAM75A3

Previous GeneCards Identifiers for SPATA31A3 Gene

  • GC09P040700

Summaries for SPATA31A3 Gene

GeneCards Summary for SPATA31A3 Gene

SPATA31A3 (SPATA31 Subfamily A Member 3) is a Protein Coding gene. Diseases associated with SPATA31A3 include Chronic Closed-Angle Glaucoma and Disuse Amblyopia. An important paralog of this gene is SPATA31A5.

UniProtKB/Swiss-Prot Summary for SPATA31A3 Gene

Additional gene information for SPATA31A3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA31A3 Gene

Genomics for SPATA31A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA31A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J066900 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 0.2 +91.7 91682 2.2 ZNF143 IRF2 GABPA ZFX NRF1 MGA ZBTB20 RAD21 ZBTB40 ZBTB26 piR-35674-529 ENSG00000277490 ZNF658 SPATA31A3
GH09J066978 Promoter 0.3 Ensembl 0.4 +13.5 13482 0.2 ENSG00000274820 ENSG00000276348 FAM74A3 piR-47677-005 SPATA31A3 ZNF658
GH09J066944 Promoter 0.6 Ensembl 0.3 +48.4 48383 0.8 RFX1 ZFX RAD21 ENSG00000277350 piR-50218-004 piR-59995-004 lnc-ZNF658-3 SPATA31A3 ZNF658
GH09J067058 Promoter 0.7 Ensembl 0.2 -67.4 -67418 3.2 ZIC2 SCRT2 ZBTB20 RAD21 ZBTB26 SIN3A GLIS1 L3MBTL2 CNTNAP3P2 lnc-ZNF658-4 piR-33432-541 SPATA31A3 ENSG00000286079
GH09J066994 Enhancer 0.2 Ensembl 0.7 -2.8 -2818 0.8 SPATA31A3 piR-36588-474 ENSG00000286079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA31A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA31A3

Genomic Locations for SPATA31A3 Gene

Genomic Locations for SPATA31A3 Gene
chr9:66,986,304-66,992,583
(GRCh38/hg38)
Size:
6,280 bases
Orientation:
Minus strand
chr9:40,700,291-40,706,537
(GRCh37/hg19)
Size:
6,247 bases
Orientation:
Plus strand

Genomic View for SPATA31A3 Gene

Genes around SPATA31A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA31A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA31A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA31A3 Gene

Proteins for SPATA31A3 Gene

  • Protein details for SPATA31A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYP0-S31A3_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 31A3
    Protein Accession:
    Q5VYP0

    Protein attributes for SPATA31A3 Gene

    Size:
    1347 amino acids
    Molecular mass:
    148706 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA31A3 Gene

Post-translational modifications for SPATA31A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA31A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA31A3 Gene

Domains & Families for SPATA31A3 Gene

Gene Families for SPATA31A3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPATA31A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA31A3 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM75A3 (F75A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VYP0

UniProtKB/Swiss-Prot:

S31A3_HUMAN :
  • Belongs to the SPATA31 family.
Family:
  • Belongs to the SPATA31 family.
genes like me logo Genes that share domains with SPATA31A3: view

Function for SPATA31A3 Gene

Molecular function for SPATA31A3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis.

Phenotypes for SPATA31A3 Gene

GenomeRNAi human phenotypes for SPATA31A3:
genes like me logo Genes that share phenotypes with SPATA31A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA31A3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA31A3 Gene

Localization for SPATA31A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA31A3 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA31A3 gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPATA31A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPATA31A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPATA31A3 Gene

Pathways & Interactions for SPATA31A3 Gene

PathCards logo

SuperPathways for SPATA31A3 Gene

No Data Available

Interacting Proteins for SPATA31A3 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000485118 Q5VYP0-S31A3_HUMAN for SPATA31A3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPATA31A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA31A3: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA31A3 Gene

Drugs & Compounds for SPATA31A3 Gene

No Compound Related Data Available

Transcripts for SPATA31A3 Gene

mRNA/cDNA for SPATA31A3 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA31A3

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA31A3 Gene

No ASD Table

Relevant External Links for SPATA31A3 Gene

GeneLoc Exon Structure for
SPATA31A3

Expression for SPATA31A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA31A3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA31A3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA31A3

SOURCE GeneReport for Unigene cluster for SPATA31A3 Gene:

Hs.632078
genes like me logo Genes that share expression patterns with SPATA31A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA31A3 Gene

Orthologs for SPATA31A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA31A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC749578 30
  • 98.42 (n)
Cow
(Bos Taurus)
Mammalia SPATA31A3 30
  • 66.44 (n)
Dog
(Canis familiaris)
Mammalia SPATA31A3 30
  • 65.62 (n)
Rat
(Rattus norvegicus)
Mammalia Spata31a5 30
  • 59.28 (n)
Mouse
(Mus musculus)
Mammalia Spata31 30
  • 58.79 (n)
Species where no ortholog for SPATA31A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPATA31A3 Gene

ENSEMBL:
Gene Tree for SPATA31A3 (if available)
TreeFam:
Gene Tree for SPATA31A3 (if available)

Paralogs for SPATA31A3 Gene

(11) SIMAP similar genes for SPATA31A3 Gene using alignment to 1 proteins:

  • S31A3_HUMAN
genes like me logo Genes that share paralogs with SPATA31A3: view

Variants for SPATA31A3 Gene

Additional dbSNP identifiers (rs#s) for SPATA31A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA31A3 Gene

Variant ID Type Subtype PubMed ID
nsv1075620 CNV deletion 25765185
nsv469605 CNV gain 16826518
nsv614322 CNV loss 21841781
nsv831560 CNV gain 17160897
nsv831561 CNV loss 17160897
nsv8456 CNV gain+loss 18304495
nsv951713 CNV deletion 24416366
nsv972329 CNV duplication 23825009

Variation tolerance for SPATA31A3 Gene

Gene Damage Index Score: 5.64; 72.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA31A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA31A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA31A3 Gene

Disorders for SPATA31A3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SPATA31A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic closed-angle glaucoma
  • anatomical narrow angle glaucoma
disuse amblyopia
  • deprivation amblyopia
megalocornea
  • anterior megalophthalmos
progressive familial heart block
  • pccd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPATA31A3

genes like me logo Genes that share disorders with SPATA31A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA31A3 Gene

Publications for SPATA31A3 Gene

  1. The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence. (PMID: 20850414) Zuo Y … Lee KF (Biochemical and biophysical research communications 2010) 2 3
  2. p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells. (PMID: 25331947) Veena MS … Srivatsan ES (The Journal of biological chemistry 2014) 3
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for SPATA31A3 Gene

Sources for SPATA31A3 Gene