Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPATA3 Gene

Aliases for SPATA3 Gene

  • Spermatogenesis Associated 3 2 3 5
  • Testis And Spermatogenesis Cell-Related Protein 1 3 4
  • Testis Spermatocyte Apoptosis-Related Protein 1 3 4
  • Spermatogenesis-Associated Protein 3 3 4
  • TSARG1 3 4
  • Testis And Spermatogenesis Cell Apoptosis Related Gene 1 3

External Ids for SPATA3 Gene

Previous GeneCards Identifiers for SPATA3 Gene

  • GC00U991161
  • GC02P232063
  • GC02P231686
  • GC02P231569
  • GC02P231860
  • GC02P223702

Summaries for SPATA3 Gene

GeneCards Summary for SPATA3 Gene

SPATA3 (Spermatogenesis Associated 3) is a Protein Coding gene. Diseases associated with SPATA3 include Cryptorchidism, Unilateral Or Bilateral.

Additional gene information for SPATA3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA3 Gene

Genomics for SPATA3 Gene

GeneHancer (GH) Regulatory Elements for SPATA3 Gene

Promoters and enhancers for SPATA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J230996 Promoter/Enhancer 0.8 EPDnew Ensembl 600.7 +2.8 2777 7.8 KDM1A SPATA3 SPATA3-AS1
GH02J230988 Enhancer 0.2 Ensembl 600.7 -1.4 -1382 0.3 SPATA3 SPATA3-AS1 GPR55
GH02J230863 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 -120.7 -120713 11.3 SP1 ZNF652 ZFX CTCF ZNF148 NKRF POLR2A NFIB AHR ZNF24 ITM2C RPL28P2 NCL ENSG00000261096 COPS7B LINC00471 ENSG00000230385 SPATA3-AS1 SPATA3 PSMD1
GH02J230924 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 12.1 -64.9 -64921 2.5 SP1 NKRF ZNF384 ZNF687 RELA CREM MLLT1 RAD21 ZBED1 IKZF1 GPR55 ENSG00000283164 SPATA3 SPATA3-AS1 ENSG00000232520 PSMD1 GC02M230912
GH02J231056 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 +67.8 67800 5 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF NKRF POLR2A CEBPG AHR PSMD1 HTR2B RPL28P2 DIS3L2 C2orf72 COPS7B NCL SPATA3-AS1 SPATA3 ENSG00000235419
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA3 gene promoter:
  • AML1a
  • AP-4
  • CREB
  • deltaCREB
  • GR-beta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • p53

Genomic Locations for SPATA3 Gene

Genomic Locations for SPATA3 Gene
chr2:230,990,324-231,025,056
(GRCh38/hg38)
Size:
34,733 bases
Orientation:
Plus strand
chr2:231,860,836-231,889,770
(GRCh37/hg19)
Size:
28,935 bases
Orientation:
Plus strand

Genomic View for SPATA3 Gene

Genes around SPATA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA3 Gene

Proteins for SPATA3 Gene

  • Protein details for SPATA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHX4-SPTA3_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 3
    Protein Accession:
    Q8NHX4
    Secondary Accessions:
    • Q86WX5
    • Q8N9Y6

    Protein attributes for SPATA3 Gene

    Size:
    192 amino acids
    Molecular mass:
    20901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA3 Gene

Post-translational modifications for SPATA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA3 Gene

Domains & Families for SPATA3 Gene

Gene Families for SPATA3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPATA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA3 Gene

GenScript: Design optimal peptide antigens:
  • Testis spermatocyte apoptosis-related protein 1 (SPTA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA3: view

No data available for UniProtKB/Swiss-Prot for SPATA3 Gene

Function for SPATA3 Gene

Phenotypes From GWAS Catalog for SPATA3 Gene

Gene Ontology (GO) - Molecular Function for SPATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPATA3: view
genes like me logo Genes that share phenotypes with SPATA3: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SPATA3 - Now 50% OFF >
  • * SPATA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPATA3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA3 Gene

Localization for SPATA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA3 gene
Compartment Confidence
nucleus 3
extracellular 1
plasma membrane 0
cytosol 0

Gene Ontology (GO) - Cellular Components for SPATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPATA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SPATA3 Gene

Pathways & Interactions for SPATA3 Gene

PathCards logo

SuperPathways for SPATA3 Gene

No Data Available

Interacting Proteins for SPATA3 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000388895%0d9606.ENSP00000377582%0d9606.ENSP00000366950%0d
Selected Interacting proteins: ENSP00000388895 Q8NHX4-SPTA3_HUMAN for SPATA3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPATA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA3 Gene

Drugs & Compounds for SPATA3 Gene

No Compound Related Data Available

Transcripts for SPATA3 Gene

mRNA/cDNA for SPATA3 Gene

Unigene Clusters for SPATA3 Gene

Spermatogenesis associated 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SPATA3 - Now 50% OFF >
  • * SPATA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPATA3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA3 Gene

No ASD Table

Relevant External Links for SPATA3 Gene

GeneLoc Exon Structure for
SPATA3
ECgene alternative splicing isoforms for
SPATA3

Expression for SPATA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA3 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA3 Gene

This gene is overexpressed in Testis (x51.6).

NURSA nuclear receptor signaling pathways regulating expression of SPATA3 Gene:

SPATA3

SOURCE GeneReport for Unigene cluster for SPATA3 Gene:

Hs.745178
genes like me logo Genes that share expression patterns with SPATA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA3 Gene

Orthologs for SPATA3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA3 35 34
  • 98.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SPATA3 35 34
  • 78.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA3 35 34
  • 72.28 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata3 34
  • 70.43 (n)
mouse
(Mus musculus)
Mammalia Spata3 17 35 34
  • 66.14 (n)
Species where no ortholog for SPATA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA3 Gene

ENSEMBL:
Gene Tree for SPATA3 (if available)
TreeFam:
Gene Tree for SPATA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA3: view image

Paralogs for SPATA3 Gene

No data available for Paralogs for SPATA3 Gene

Variants for SPATA3 Gene

Sequence variations from dbSNP and Humsavar for SPATA3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000039067 -- 231,020,237(+) A/G downstream_transcript_variant
rs1000241669 -- 231,004,558(+) G/A intron_variant
rs1000409566 -- 231,015,719(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000461907 -- 231,016,019(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000562494 -- 231,016,848(+) A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA3 Gene

Variant ID Type Subtype PubMed ID
esv2721608 CNV deletion 23290073
esv3387907 CNV duplication 20981092
nsv954230 CNV deletion 24416366

Variation tolerance for SPATA3 Gene

Gene Damage Index Score: 9.49; 88.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA3 Gene

Disorders for SPATA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPATA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPATA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPATA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA3 Gene

Publications for SPATA3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. [Molecular cloning for testis spermatogenesis cell apoptosis related gene TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene]. (PMID: 12812072) Fu JJ … Liu SF (Yi chuan xue bao = Acta genetica Sinica 2003) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for SPATA3 Gene

Sources for SPATA3 Gene

Content
Loading form....