Aliases for SPATA3 Gene

Aliases for SPATA3 Gene

  • Spermatogenesis Associated 3 2 3 5
  • TSARG1 2 3 4
  • Testis And Spermatogenesis Cell-Related Protein 1 3 4
  • Testis Spermatocyte Apoptosis-Related Protein 1 3 4
  • Spermatogenesis-Associated Protein 3 3 4
  • Testis And Spermatogenesis Cell Apoptosis Related Gene 1 3
  • SPATA3 5

External Ids for SPATA3 Gene

Previous GeneCards Identifiers for SPATA3 Gene

  • GC00U991161
  • GC02P232063
  • GC02P231686
  • GC02P231569
  • GC02P231860
  • GC02P223702

Summaries for SPATA3 Gene

GeneCards Summary for SPATA3 Gene

SPATA3 (Spermatogenesis Associated 3) is a Protein Coding gene. Diseases associated with SPATA3 include Spermatogenic Failure 9.

Additional gene information for SPATA3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA3 Gene

Genomics for SPATA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J230996 Promoter 0.3 EPDnew 600.4 +5.8 5753 0.1 HSALNG0022912 SPATA3-AS1 SPATA3 C2orf72
GH02J230863 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -120.8 -120781 11.7 SP1 HNRNPL GATAD2A TEAD4 PRDM10 IKZF1 CTCF POLR2A ZNF692 ZNF300 ITM2C RPL28P2 NCL ENSG00000261096 COPS7B LINC00471 ENSG00000230385 SPATA3 SPATA3-AS1 PSMD1
GH02J231056 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +68.0 68000 4.6 SP1 GATAD2A CTCF PRDM10 ZNF629 REST ZNF692 POLR2A BACH1 JUND LOC112268432 PSMD1 HTR2B DIS3L2 C2orf72 RPL28P2 COPS7B ENSG00000224376 SPATA3-AS1 SPATA3
GH02J230924 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 12.1 -64.9 -64921 2.5 SP1 CTCF POLR2A LARP7 STAT3 ZNF143 RELA ZIC2 SMAD5 RAD21 GPR55 SPATA3 SPATA3-AS1 GCSIR PSMD1 ENSG00000283164 lnc-SPATA3-1 ITM2C
GH02J230847 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 11.9 -142.3 -142293 0.3 GATAD2A CTCF ZNF629 TFE3 NFKBIZ ZNF692 RCOR2 JUND LARP7 ZNF143 GCSIR SPATA3 SPATA3-AS1 piR-49423-140 HSALNG0022902 ITM2C CAB39
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA3

Top Transcription factor binding sites by QIAGEN in the SPATA3 gene promoter:
  • AML1a
  • AP-4
  • CREB
  • deltaCREB
  • GR-beta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • p53

Genomic Locations for SPATA3 Gene

Genomic Locations for SPATA3 Gene
34,732 bases
Plus strand
28,935 bases
Plus strand

Genomic View for SPATA3 Gene

Genes around SPATA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA3 Gene

Proteins for SPATA3 Gene

  • Protein details for SPATA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 3
    Protein Accession:
    Secondary Accessions:
    • Q86WX5
    • Q8N9Y6

    Protein attributes for SPATA3 Gene

    192 amino acids
    Molecular mass:
    20901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA3 Gene

Post-translational modifications for SPATA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA3 Gene

Domains & Families for SPATA3 Gene

Gene Families for SPATA3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPATA3 Gene


Suggested Antigen Peptide Sequences for SPATA3 Gene

GenScript: Design optimal peptide antigens:
  • Testis spermatocyte apoptosis-related protein 1 (SPTA3_HUMAN)
genes like me logo Genes that share domains with SPATA3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA3 Gene

Function for SPATA3 Gene

Phenotypes From GWAS Catalog for SPATA3 Gene

Gene Ontology (GO) - Molecular Function for SPATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPATA3: view
genes like me logo Genes that share phenotypes with SPATA3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA3 Gene

Localization for SPATA3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA3 gene
Compartment Confidence
nucleus 3
extracellular 1
golgi apparatus 1
plasma membrane 0
cytosol 0

Gene Ontology (GO) - Cellular Components for SPATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPATA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SPATA3 Gene

Pathways & Interactions for SPATA3 Gene

PathCards logo

SuperPathways for SPATA3 Gene

No Data Available

Interacting Proteins for SPATA3 Gene

Gene Ontology (GO) - Biological Process for SPATA3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA3 Gene

Drugs & Compounds for SPATA3 Gene

No Compound Related Data Available

Transcripts for SPATA3 Gene

mRNA/cDNA for SPATA3 Gene

9 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA3

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA3 Gene

No ASD Table

Relevant External Links for SPATA3 Gene

GeneLoc Exon Structure for

Expression for SPATA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SPATA3 Gene

This gene is overexpressed in Testis (x51.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA3

SOURCE GeneReport for Unigene cluster for SPATA3 Gene:

genes like me logo Genes that share expression patterns with SPATA3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA3 Gene

Orthologs for SPATA3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA3 30 31
  • 98.09 (n)
(Bos Taurus)
Mammalia SPATA3 30 31
  • 78.77 (n)
(Canis familiaris)
Mammalia SPATA3 30 31
  • 72.28 (n)
(Rattus norvegicus)
Mammalia Spata3 30
  • 70.43 (n)
(Mus musculus)
Mammalia Spata3 30 17 31
  • 66.14 (n)
Species where no ortholog for SPATA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPATA3 Gene

Gene Tree for SPATA3 (if available)
Gene Tree for SPATA3 (if available)
Evolutionary constrained regions (ECRs) for SPATA3: view image

Paralogs for SPATA3 Gene

No data available for Paralogs for SPATA3 Gene

Variants for SPATA3 Gene

Additional dbSNP identifiers (rs#s) for SPATA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA3 Gene

Variant ID Type Subtype PubMed ID
esv2721608 CNV deletion 23290073
esv3387907 CNV duplication 20981092
nsv954230 CNV deletion 24416366

Variation tolerance for SPATA3 Gene

Gene Damage Index Score: 9.49; 88.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA3 Gene

Disorders for SPATA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPATA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatogenic failure 9
  • globozoospermia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPATA3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SPATA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA3 Gene

Publications for SPATA3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. [Molecular cloning for testis spermatogenesis cell apoptosis related gene TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene]. (PMID: 12812072) Fu JJ … Liu SF (Yi chuan xue bao = Acta genetica Sinica 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for SPATA3 Gene

Sources for SPATA3 Gene