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Aliases for SPATA2L Gene

Aliases for SPATA2L Gene

  • Spermatogenesis Associated 2 Like 2 3 5
  • SPATA2-Like Protein 3 4
  • C16orf76 3 4
  • Spermatogenesis-Associated Protein 2-Like Protein 3
  • Chromosome 16 Open Reading Frame 76 2
  • Tamo 3

External Ids for SPATA2L Gene

Previous HGNC Symbols for SPATA2L Gene

  • C16orf76

Previous GeneCards Identifiers for SPATA2L Gene

  • GC16M088292
  • GC16M089762
  • GC16M075458

Summaries for SPATA2L Gene

GeneCards Summary for SPATA2L Gene

SPATA2L (Spermatogenesis Associated 2 Like) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2.

Additional gene information for SPATA2L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA2L Gene

Genomics for SPATA2L Gene

GeneHancer (GH) Regulatory Elements for SPATA2L Gene

Promoters and enhancers for SPATA2L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I089699 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 515 2.9 HDGF PKNOX1 CLOCK MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 SPATA2L CDK10 CHMP1A ACSF3 ANKRD11 ZNF778 GALNS TCF25 SNORD68 ENSG00000268218
GH16I089842 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.9 -141.4 -141389 1.5 NFIB SIN3A ZNF48 RFX5 ZNF335 ZNF121 GLIS2 ZNF366 EGR1 FOS SPATA2L SPIRE2 CDK10 FANCA VPS9D1 ZNF276 LOC105371419
GH16I089480 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.8 +215.0 214959 12 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 ANKRD11 SPG7 ZNF778 ZC3H18 AFG3L1P MC1R ENSG00000259877 RPL13 TCF25 RNU6-430P
GH16I089763 Enhancer 1 Ensembl ENCODE 12.1 -63.0 -62959 2.9 HDGF PKNOX1 BMI1 BATF IRF4 RAD21 ZNF207 ZNF143 ATF7 ETV6 FANCA CDK10 SPIRE2 VPS9D1 ZNF276 SPATA2L GAS8 PIR55781
GH16I089846 Enhancer 0.8 ENCODE dbSUPER 12 -145.8 -145834 1.5 KLF1 RFX1 ZNF189 ZNF10 ZIC2 ZNF335 ZFHX2 PRDM6 POLR2A GLIS1 FANCA SPIRE2 DBNDD1 CDK10 SPATA2L VPS9D1 ZNF276 LOC105371419
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATA2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA2L gene promoter:

Genomic Locations for SPATA2L Gene

Genomic Locations for SPATA2L Gene
chr16:89,696,343-89,701,713
(GRCh38/hg38)
Size:
5,371 bases
Orientation:
Minus strand
chr16:89,762,751-89,768,121
(GRCh37/hg19)

Genomic View for SPATA2L Gene

Genes around SPATA2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA2L Gene

Proteins for SPATA2L Gene

  • Protein details for SPATA2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUW3-SPA2L_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 2-like protein
    Protein Accession:
    Q8IUW3
    Secondary Accessions:
    • D3DX85
    • Q8NHV3

    Protein attributes for SPATA2L Gene

    Size:
    424 amino acids
    Molecular mass:
    46179 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA2L Gene

Post-translational modifications for SPATA2L Gene

No Post-translational modifications

Other Protein References for SPATA2L Gene

No data available for DME Specific Peptides for SPATA2L Gene

Domains & Families for SPATA2L Gene

Gene Families for SPATA2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA2L Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPATA2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUW3

UniProtKB/Swiss-Prot:

SPA2L_HUMAN :
  • Belongs to the SPATA2 family.
Family:
  • Belongs to the SPATA2 family.
genes like me logo Genes that share domains with SPATA2L: view

Function for SPATA2L Gene

Phenotypes From GWAS Catalog for SPATA2L Gene

genes like me logo Genes that share phenotypes with SPATA2L: view

Animal Model Products

miRNA for SPATA2L Gene

miRTarBase miRNAs that target SPATA2L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA2L Gene

Localization for SPATA2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA2L gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA2L Gene

Pathways & Interactions for SPATA2L Gene

SuperPathways for SPATA2L Gene

SuperPathway Contained pathways
1 Necroptosis
genes like me logo Genes that share pathways with SPATA2L: view

Pathways by source for SPATA2L Gene

1 KEGG pathway for SPATA2L Gene

Gene Ontology (GO) - Biological Process for SPATA2L Gene

None

No data available for SIGNOR curated interactions for SPATA2L Gene

Drugs & Compounds for SPATA2L Gene

No Compound Related Data Available

Transcripts for SPATA2L Gene

Unigene Clusters for SPATA2L Gene

Spermatogenesis associated 2-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3:

Relevant External Links for SPATA2L Gene

GeneLoc Exon Structure for
SPATA2L
ECgene alternative splicing isoforms for
SPATA2L

Expression for SPATA2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATA2L Gene

This gene is overexpressed in Heart (45.4) and Peripheral blood mononuclear cells (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA2L Gene



Protein tissue co-expression partners for SPATA2L Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA2L Gene:

SPATA2L

SOURCE GeneReport for Unigene cluster for SPATA2L Gene:

Hs.374556

Evidence on tissue expression from TISSUES for SPATA2L Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SPATA2L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA2L Gene

Orthologs for SPATA2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA2L 33 34
  • 99.06 (n)
rat
(Rattus norvegicus)
Mammalia Spata2L 33
  • 82.82 (n)
dog
(Canis familiaris)
Mammalia SPATA2L 33 34
  • 82.78 (n)
cow
(Bos Taurus)
Mammalia SPATA2L 33 34
  • 82.52 (n)
mouse
(Mus musculus)
Mammalia Spata2l 33 16 34
  • 81.4 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA2L 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA2L 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA2L 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA2L 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata2l 33
  • 43.77 (n)
zebrafish
(Danio rerio)
Actinopterygii spata2l 34
  • 13 (a)
OneToOne
Species where no ortholog for SPATA2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA2L Gene

ENSEMBL:
Gene Tree for SPATA2L (if available)
TreeFam:
Gene Tree for SPATA2L (if available)

Paralogs for SPATA2L Gene

Paralogs for SPATA2L Gene

genes like me logo Genes that share paralogs with SPATA2L: view

Variants for SPATA2L Gene

Sequence variations from dbSNP and Humsavar for SPATA2L Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000544928 -- 89,702,512(-) T/A upstream_transcript_variant
rs1000602073 -- 89,702,971(-) G/C upstream_transcript_variant
rs1000616039 -- 89,698,936(-) C/A/T intron_variant
rs1000909763 -- 89,702,742(-) G/A/C upstream_transcript_variant
rs1001016784 -- 89,700,793(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA2L Gene

Variant ID Type Subtype PubMed ID
nsv952079 CNV deletion 24416366
nsv833330 CNV loss 17160897
nsv573743 CNV gain 21841781
nsv573739 CNV gain 21841781
nsv516241 CNV loss 19592680
nsv509639 CNV insertion 20534489
nsv482951 CNV loss 15286789
nsv457623 CNV gain 19166990
nsv428331 CNV gain+loss 18775914
nsv1057351 CNV loss 25217958
esv2762221 CNV gain+loss 21179565

Variation tolerance for SPATA2L Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA2L Gene

Disorders for SPATA2L Gene

Additional Disease Information for SPATA2L

No disorders were found for SPATA2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA2L Gene

Publications for SPATA2L Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa ME … Harper JW (Cell 2009) 3 58

Products for SPATA2L Gene

Sources for SPATA2L Gene

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