Aliases for SPATA2L Gene

Aliases for SPATA2L Gene

  • Spermatogenesis Associated 2 Like 2 3 5
  • Spermatogenesis-Associated Protein 2-Like Protein 3 4
  • SPATA2-Like Protein 3 4
  • C16orf76 3 4
  • Tamo 2 3
  • Chromosome 16 Open Reading Frame 76 2
  • MGC26885 2
  • SPATA2L 5

External Ids for SPATA2L Gene

Previous HGNC Symbols for SPATA2L Gene

  • C16orf76

Previous GeneCards Identifiers for SPATA2L Gene

  • GC16M088292
  • GC16M089762
  • GC16M075458

Summaries for SPATA2L Gene

GeneCards Summary for SPATA2L Gene

SPATA2L (Spermatogenesis Associated 2 Like) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2.

Additional gene information for SPATA2L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA2L Gene

Genomics for SPATA2L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA2L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA2L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA2L

Top Transcription factor binding sites by QIAGEN in the SPATA2L gene promoter:
  • AhR
  • AML1a
  • CP2
  • CUTL1
  • NRF-2
  • Olf-1
  • POU2F1
  • POU2F1a
  • XBP-1

Genomic Locations for SPATA2L Gene

Latest Assembly
5,349 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
5,349 bases
Minus strand

(GRCh37/hg19 by Ensembl)
5,363 bases
Minus strand

Genomic View for SPATA2L Gene

Genes around SPATA2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA2L Gene

Proteins for SPATA2L Gene

  • Protein details for SPATA2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 2-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DX85
    • Q8NHV3

    Protein attributes for SPATA2L Gene

    424 amino acids
    Molecular mass:
    46179 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA2L Gene


neXtProt entry for SPATA2L Gene

Post-translational modifications for SPATA2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA2L Gene

No data available for DME Specific Peptides for SPATA2L Gene

Domains & Families for SPATA2L Gene

Gene Families for SPATA2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA2L Gene


Suggested Antigen Peptide Sequences for SPATA2L Gene

GenScript: Design optimal peptide antigens:
  • Spermatogenesis-associated protein 2-like protein (SPA2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPATA2 family.
  • Belongs to the SPATA2 family.
genes like me logo Genes that share domains with SPATA2L: view

Function for SPATA2L Gene

Phenotypes From GWAS Catalog for SPATA2L Gene

Gene Ontology (GO) - Molecular Function for SPATA2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with SPATA2L: view
genes like me logo Genes that share phenotypes with SPATA2L: view

miRNA for SPATA2L Gene

miRTarBase miRNAs that target SPATA2L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA2L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA2L Gene

Localization for SPATA2L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA2L gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with SPATA2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPATA2L Gene

Pathways & Interactions for SPATA2L Gene

PathCards logo

SuperPathways for SPATA2L Gene

SuperPathway Contained pathways
1 Necroptosis
genes like me logo Genes that share pathways with SPATA2L: view

Pathways by source for SPATA2L Gene

1 KEGG pathway for SPATA2L Gene

Gene Ontology (GO) - Biological Process for SPATA2L Gene


No data available for SIGNOR curated interactions for SPATA2L Gene

Drugs & Compounds for SPATA2L Gene

No Compound Related Data Available

Transcripts for SPATA2L Gene

mRNA/cDNA for SPATA2L Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA2L

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -

Relevant External Links for SPATA2L Gene

GeneLoc Exon Structure for

Expression for SPATA2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATA2L Gene

This gene is overexpressed in Heart (45.4) and Peripheral blood mononuclear cells (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA2L Gene

Protein tissue co-expression partners for SPATA2L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA2L

SOURCE GeneReport for Unigene cluster for SPATA2L Gene:


Evidence on tissue expression from TISSUES for SPATA2L Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SPATA2L: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA2L Gene

Orthologs for SPATA2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA2L 30 31
  • 99.06 (n)
(Rattus norvegicus)
Mammalia Spata2L 30
  • 82.82 (n)
(Canis familiaris)
Mammalia SPATA2L 30 31
  • 82.78 (n)
(Bos Taurus)
Mammalia SPATA2L 30 31
  • 82.52 (n)
(Mus musculus)
Mammalia Spata2l 30 17 31
  • 81.4 (n)
(Monodelphis domestica)
Mammalia SPATA2L 31
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA2L 31
  • 56 (a)
(Gallus gallus)
Aves SPATA2L 31
  • 41 (a)
(Anolis carolinensis)
Reptilia SPATA2L 31
  • 38 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spata2l 30
  • 43.77 (n)
(Danio rerio)
Actinopterygii spata2l 31
  • 13 (a)
Species where no ortholog for SPATA2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPATA2L Gene

Gene Tree for SPATA2L (if available)
Gene Tree for SPATA2L (if available)
Evolutionary constrained regions (ECRs) for SPATA2L: view image

Paralogs for SPATA2L Gene

Paralogs for SPATA2L Gene

genes like me logo Genes that share paralogs with SPATA2L: view

Variants for SPATA2L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPATA2L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPATA2L Gene

Variant ID Type Subtype PubMed ID
esv2762221 CNV gain+loss 21179565
nsv1057351 CNV loss 25217958
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv516241 CNV loss 19592680
nsv573739 CNV gain 21841781
nsv573743 CNV gain 21841781
nsv833330 CNV loss 17160897
nsv952079 CNV deletion 24416366

Variation tolerance for SPATA2L Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA2L Gene

Disorders for SPATA2L Gene

Additional Disease Information for SPATA2L

No disorders were found for SPATA2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA2L Gene

Publications for SPATA2L Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3
  2. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. (PMID: 31762063) Yang XD … Su B (The EMBO journal 2020) 3
  3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. (PMID: 30561431) Van Quickelberghe E … Gevaert K (Scientific data 2018) 3

Products for SPATA2L Gene

Sources for SPATA2L Gene