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Aliases for SPATA25 Gene

Aliases for SPATA25 Gene

  • Spermatogenesis Associated 25 2 3 5
  • Testis-Specific Gene 23 Protein 3 4
  • C20orf165 3 4
  • TSG23 3 4
  • Spermatogenesis-Associated Protein 25 3
  • Chromosome 20 Open Reading Frame 165 2
  • DJ337O18.8 3

External Ids for SPATA25 Gene

Previous HGNC Symbols for SPATA25 Gene

  • C20orf165

Previous GeneCards Identifiers for SPATA25 Gene

  • GC20M044516

Summaries for SPATA25 Gene

GeneCards Summary for SPATA25 Gene

SPATA25 (Spermatogenesis Associated 25) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA25 Gene

  • May play a role in spermatogenesis.

Additional gene information for SPATA25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA25 Gene

Genomics for SPATA25 Gene

GeneHancer (GH) Regulatory Elements for SPATA25 Gene

Promoters and enhancers for SPATA25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J045883 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +2.6 2606 4.4 HDGF IRF4 GLIS2 ZFP91 FOS ATF7 RUNX3 DEK NCOA1 JUNB SPATA25 WFDC3 CD40 PCIF1 NCOA5 ZNF335 ENSG00000271984 SLC35C2 PLTP ZSWIM1
GH20J045933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.6 -47.7 -47677 6.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCIF1 NCOA5 SNX21 TP53RK SPATA25 ZNF335 PLTP SLC35C2 WFDC3 FTLP1
GH20J045880 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.2 +7.4 7381 1.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZSWIM1 NCOA5 TP53RK CD40 WFDC3 SPATA25 PCIF1 SLC35C2 ZNF335 RPS2P7
GH20J045967 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 19.4 -82.2 -82221 5.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF335 NCOA5 TP53RK SLC35C2 PCIF1 CD40 ZNF334 ZNF663P ZSWIM1 ENSG00000271984
GH20J046405 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 14.1 -517.9 -517942 2.7 PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 ZNF143 FOS KLF13 ELMO2 LOC105372633 NCOA5 TP53RK MKRN7P SPATA25 LOC100131496 GC20M046352
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPATA25 Gene

Genomic Locations for SPATA25 Gene
2,168 bases
Minus strand
1,147 bases
Minus strand

Genomic View for SPATA25 Gene

Genes around SPATA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA25 Gene

Proteins for SPATA25 Gene

  • Protein details for SPATA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 25
    Protein Accession:

    Protein attributes for SPATA25 Gene

    227 amino acids
    Molecular mass:
    23834 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA25 Gene

Post-translational modifications for SPATA25 Gene

No Post-translational modifications

Other Protein References for SPATA25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA25 Gene

Domains & Families for SPATA25 Gene

Gene Families for SPATA25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA25 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPATA25 family.
  • Belongs to the SPATA25 family.
genes like me logo Genes that share domains with SPATA25: view

No data available for Suggested Antigen Peptide Sequences for SPATA25 Gene

Function for SPATA25 Gene

Molecular function for SPATA25 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis.

Phenotypes From GWAS Catalog for SPATA25 Gene

Gene Ontology (GO) - Molecular Function for SPATA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPATA25: view
genes like me logo Genes that share phenotypes with SPATA25: view

Animal Models for SPATA25 Gene

MGI Knock Outs for SPATA25:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA25 Gene

Localization for SPATA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA25 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA25 gene
Compartment Confidence
extracellular 3
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPATA25: view

Pathways & Interactions for SPATA25 Gene

SuperPathways for SPATA25 Gene

No Data Available

Interacting Proteins for SPATA25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361597 for SPATA25 Gene via STRING

Gene Ontology (GO) - Biological Process for SPATA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEP 19240080
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA25: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA25 Gene

Drugs & Compounds for SPATA25 Gene

No Compound Related Data Available

Transcripts for SPATA25 Gene

mRNA/cDNA for SPATA25 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA25 Gene

Spermatogenesis associated 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA25 Gene

No ASD Table

Relevant External Links for SPATA25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA25 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA25 Gene

This gene is overexpressed in Testis (x7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA25 Gene:


SOURCE GeneReport for Unigene cluster for SPATA25 Gene:


mRNA Expression by UniProt/SwissProt for SPATA25 Gene:

Tissue specificity: Expressed predominantly in testis (at protein level). Expression is lower in patients with obstructive azoospermia than in fertile controls and is not detected in patients with non-obstructive azoospermia.

Evidence on tissue expression from TISSUES for SPATA25 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPATA25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA25 Gene

Orthologs for SPATA25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA25 34 33
  • 98.38 (n)
(Canis familiaris)
Mammalia SPATA25 34 33
  • 88.84 (n)
(Rattus norvegicus)
Mammalia Spata25 33
  • 86.1 (n)
(Mus musculus)
Mammalia Spata25 16 34 33
  • 84.75 (n)
(Bos Taurus)
Mammalia SPATA25 34 33
  • 84.25 (n)
(Monodelphis domestica)
Mammalia SPATA25 34
  • 70 (a)
Species where no ortholog for SPATA25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA25 Gene

Gene Tree for SPATA25 (if available)
Gene Tree for SPATA25 (if available)
Evolutionary constrained regions (ECRs) for SPATA25: view image

Paralogs for SPATA25 Gene

No data available for Paralogs for SPATA25 Gene

Variants for SPATA25 Gene

Sequence variations from dbSNP and Humsavar for SPATA25 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000460046 -- 45,889,581(-) T/A upstream_transcript_variant
rs1003060294 -- 45,889,154(-) T/G upstream_transcript_variant
rs1003266283 -- 45,887,913(-) C/A upstream_transcript_variant
rs1003334266 -- 45,889,358(-) T/C upstream_transcript_variant
rs1005121712 -- 45,889,434(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA25 Gene

Variant ID Type Subtype PubMed ID
nsv517296 CNV loss 19592680
nsv833990 CNV loss 17160897
nsv833991 CNV loss 17160897

Variation tolerance for SPATA25 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA25 Gene

Disorders for SPATA25 Gene

Additional Disease Information for SPATA25

No disorders were found for SPATA25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA25 Gene

Publications for SPATA25 Gene

  1. Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis. (PMID: 19240080) Zhou Y … Gui Y (Molecular human reproduction 2009) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SPATA25 Gene

  • Biorbyt antibodies for SPATA25

Sources for SPATA25 Gene

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