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Aliases for SPATA21 Gene

Aliases for SPATA21 Gene

  • Spermatogenesis Associated 21 2 3 5
  • Spermatogenesis-Associated Protein 21 3 4
  • Spergen-2 3
  • Spergen2 3

External Ids for SPATA21 Gene

Previous GeneCards Identifiers for SPATA21 Gene

  • GC01M016471
  • GC01M016597
  • GC01M016714
  • GC01M015242

Summaries for SPATA21 Gene

GeneCards Summary for SPATA21 Gene

SPATA21 (Spermatogenesis Associated 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is EFCAB6.

UniProtKB/Swiss-Prot for SPATA21 Gene

Additional gene information for SPATA21 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA21 Gene

Genomics for SPATA21 Gene

GeneHancer (GH) Regulatory Elements for SPATA21 Gene

Promoters and enhancers for SPATA21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA21 gene promoter:
  • AML1a
  • c-Ets-1
  • E47
  • LyF-1
  • POU2F1
  • POU2F1a
  • RORalpha2
  • SRF
  • SRF (504 AA)
  • Tal-1beta

Genomic Locations for SPATA21 Gene

Genomic Locations for SPATA21 Gene
50,726 bases
Minus strand
50,308 bases
Minus strand

Genomic View for SPATA21 Gene

Genes around SPATA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA21 Gene

Proteins for SPATA21 Gene

  • Protein details for SPATA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 21
    Protein Accession:
    Secondary Accessions:
    • B9EK40
    • F5GXP5

    Protein attributes for SPATA21 Gene

    469 amino acids
    Molecular mass:
    52207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA21 Gene


neXtProt entry for SPATA21 Gene

Post-translational modifications for SPATA21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA21 Gene

Domains & Families for SPATA21 Gene

Gene Families for SPATA21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA21 Gene

Suggested Antigen Peptide Sequences for SPATA21 Gene

GenScript: Design optimal peptide antigens:
  • SPATA21 protein (B9EK40_HUMAN)
  • Spermatogenesis-associated protein 21 (SPT21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA21: view

No data available for UniProtKB/Swiss-Prot for SPATA21 Gene

Function for SPATA21 Gene

Molecular function for SPATA21 Gene

UniProtKB/Swiss-Prot Function:
Involved in the differentiation of haploid spermatids.

Gene Ontology (GO) - Molecular Function for SPATA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPATA21: view
genes like me logo Genes that share phenotypes with SPATA21: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SPATA21 - Now 50% OFF >
  • * SPATA21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPATA21 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA21 Gene

Localization for SPATA21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA21 gene
Compartment Confidence
cytosol 3
mitochondrion 1
peroxisome 1
nucleus 1
plasma membrane 0
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA21 Gene

Pathways & Interactions for SPATA21 Gene

PathCards logo

SuperPathways for SPATA21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA21 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA21 Gene

Drugs & Compounds for SPATA21 Gene

No Compound Related Data Available

Transcripts for SPATA21 Gene

mRNA/cDNA for SPATA21 Gene

Unigene Clusters for SPATA21 Gene

Spermatogenesis associated 21:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SPATA21 - Now 50% OFF >
  • * SPATA21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPATA21 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - -
SP3: - - - - - -

Relevant External Links for SPATA21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA21 Gene

This gene is overexpressed in Testis (x28.2), Liver (x4.7), Brain - Cerebellum (x4.2), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for SPATA21 Gene

This gene is overexpressed in Plasma (33.5), Monocytes (20.1), and Tlymphocyte (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA21 Gene

Protein tissue co-expression partners for SPATA21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA21 Gene:


SOURCE GeneReport for Unigene cluster for SPATA21 Gene:

genes like me logo Genes that share expression patterns with SPATA21: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA21 Gene

Orthologs for SPATA21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA21 35 34
  • 99.19 (n)
(Canis familiaris)
Mammalia SPATA21 35 34
  • 78.65 (n)
(Rattus norvegicus)
Mammalia Spata21 34
  • 76.5 (n)
(Bos Taurus)
Mammalia SPATA21 35 34
  • 76.33 (n)
(Mus musculus)
Mammalia Spata21 17 35 34
  • 75.13 (n)
(Ornithorhynchus anatinus)
Mammalia SPATA21 35
  • 27 (a)
(Monodelphis domestica)
Mammalia SPATA21 35
  • 17 (a)
(Gallus gallus)
Aves -- 35
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
Species where no ortholog for SPATA21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA21 Gene

Gene Tree for SPATA21 (if available)
Gene Tree for SPATA21 (if available)
Evolutionary constrained regions (ECRs) for SPATA21: view image

Paralogs for SPATA21 Gene

Paralogs for SPATA21 Gene

genes like me logo Genes that share paralogs with SPATA21: view

Variants for SPATA21 Gene

Sequence variations from dbSNP and Humsavar for SPATA21 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1343712054 A breast cancer sample 16,421,936(-) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000015713 -- 16,411,034(-) A/G 5_prime_UTR_variant, intron_variant
rs1000107244 -- 16,409,282(-) C/G intron_variant
rs1000171612 -- 16,408,175(-) G/T intron_variant
rs1000178275 -- 16,425,962(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA21 Gene

Variant ID Type Subtype PubMed ID
dgv19n67 CNV loss 20364138
esv1035588 CNV insertion 17803354
esv2674598 CNV deletion 23128226
esv2675247 CNV deletion 23128226
esv2744408 CNV deletion 23290073
esv3577751 CNV loss 25503493
esv3585337 CNV gain 21293372
esv3585338 CNV loss 21293372
nsv829581 CNV loss 20364138

Variation tolerance for SPATA21 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.39; 81.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA21 Gene

Disorders for SPATA21 Gene

Additional Disease Information for SPATA21

No disorders were found for SPATA21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA21 Gene

Publications for SPATA21 Gene

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SPATA21 Gene

Sources for SPATA21 Gene

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