Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPATA20 Gene

Aliases for SPATA20 Gene

  • Spermatogenesis Associated 20 2 3 5
  • Sperm-Specific Protein 411 3 4
  • SSP411 3 4
  • Transcript Increased In Spermiogenesis 78 3
  • Spermatogenesis-Associated Protein 20 3
  • Epididymis Secretory Protein Li 98 3
  • Hypothetical Protein FLJ21347 2
  • Sperm Protein SSP411 3
  • HEL-S-98 3
  • Tisp78 3

External Ids for SPATA20 Gene

Previous GeneCards Identifiers for SPATA20 Gene

  • GC17P045980
  • GC17P048624
  • GC17P043992

Summaries for SPATA20 Gene

GeneCards Summary for SPATA20 Gene

SPATA20 (Spermatogenesis Associated 20) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA20 Gene

  • May play a role in fertility regulation.

Additional gene information for SPATA20 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA20 Gene

Genomics for SPATA20 Gene

GeneHancer (GH) Regulatory Elements for SPATA20 Gene

Promoters and enhancers for SPATA20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I050546 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 656.5 +4.4 4351 1.8 HDGF ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143 KLF13 SP3 SPATA20 LUC7L3 PIR57018
GH17I050539 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 587.9 -1.0 -991 4.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF143 SP3 SP5 SPATA20 ENSG00000262837 MBTD1 LOC105371824 EPN3 FAM117A UTP18 FLJ45513 XYLT2
GH17I050558 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 91 +16.7 16703 2.9 PKNOX1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 FOS SP3 RXRA SP5 CACNA1G SPATA20 MBTD1 KAT7 CACNA1G-AS1 PIR57018
GH17I050550 Enhancer 1.1 ENCODE dbSUPER 44.6 +7.9 7918 1.1 ARID4B SIN3A ZNF48 ARID2 ZNF143 RXRA MXD4 REST MIER2 KAT8 PIR57018 SPATA20
GH17I050532 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 25.5 -9.0 -9042 3.8 ARID4B SIN3A GLI4 ZBTB7B GLIS2 ELK1 ZNF143 FOS SP3 ZNF592 EPN3 SPATA20 CACNA1G-AS1 MYCBPAP CACNA1G LOC105371824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATA20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA20 gene promoter:

Genomic Locations for SPATA20 Gene

Genomic Locations for SPATA20 Gene
chr17:50,543,058-50,555,852
(GRCh38/hg38)
Size:
12,795 bases
Orientation:
Plus strand
chr17:48,620,419-48,633,213
(GRCh37/hg19)

Genomic View for SPATA20 Gene

Genes around SPATA20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA20 Gene

Proteins for SPATA20 Gene

  • Protein details for SPATA20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB22-SPT20_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 20
    Protein Accession:
    Q8TB22
    Secondary Accessions:
    • Q2TA99
    • Q2XUZ6
    • Q6P0P1
    • Q8WVW3
    • Q9H747

    Protein attributes for SPATA20 Gene

    Size:
    786 amino acids
    Molecular mass:
    87899 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA20 Gene

Post-translational modifications for SPATA20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA20 Gene

Domains & Families for SPATA20 Gene

Gene Families for SPATA20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SPATA20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA20: view

No data available for UniProtKB/Swiss-Prot for SPATA20 Gene

Function for SPATA20 Gene

Molecular function for SPATA20 Gene

UniProtKB/Swiss-Prot Function:
May play a role in fertility regulation.

Phenotypes From GWAS Catalog for SPATA20 Gene

Gene Ontology (GO) - Molecular Function for SPATA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with SPATA20: view
genes like me logo Genes that share phenotypes with SPATA20: view

Animal Model Products

CRISPR Products

miRNA for SPATA20 Gene

miRTarBase miRNAs that target SPATA20

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA20 Gene

Localization for SPATA20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA20 gene
Compartment Confidence
extracellular 3
nucleus 3
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPATA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPATA20: view

Pathways & Interactions for SPATA20 Gene

SuperPathways for SPATA20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA20: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA20 Gene

Drugs & Compounds for SPATA20 Gene

No Compound Related Data Available

Transcripts for SPATA20 Gene

Unigene Clusters for SPATA20 Gene

Spermatogenesis associated 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA20 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - -
SP10: - - - - - -
SP11: - -
SP12:
SP13: - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - -
SP16: -
SP17:
SP18:
SP19:
SP20: - - - - -
SP21: -
SP22:
SP23: -
SP24: - - - - - - - -
SP25:

ExUns: 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22: - -
SP23:
SP24:
SP25: - -

Relevant External Links for SPATA20 Gene

GeneLoc Exon Structure for
SPATA20
ECgene alternative splicing isoforms for
SPATA20

Expression for SPATA20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA20 Gene

Protein differential expression in normal tissues from HIPED for SPATA20 Gene

This gene is overexpressed in Adrenal (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPATA20 Gene



Protein tissue co-expression partners for SPATA20 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA20 Gene:

SPATA20

SOURCE GeneReport for Unigene cluster for SPATA20 Gene:

Hs.103147

Evidence on tissue expression from TISSUES for SPATA20 Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Intestine(4.3)
  • Pancreas(4.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SPATA20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA20 Gene

Orthologs for SPATA20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPATA20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA20 33 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia SPATA20 33 34
  • 90.15 (n)
dog
(Canis familiaris)
Mammalia SPATA20 33
  • 89.15 (n)
rat
(Rattus norvegicus)
Mammalia Spata20 33
  • 84.55 (n)
mouse
(Mus musculus)
Mammalia Spata20 33 16 34
  • 84.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SPATA20 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA20 33 34
  • 67.54 (n)
lizard
(Anolis carolinensis)
Reptilia SPATA20 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata20 33
  • 60.92 (n)
zebrafish
(Danio rerio)
Actinopterygii spata20 33 34
  • 60.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008252 33
  • 51.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8613 33 34
  • 51.97 (n)
worm
(Caenorhabditis elegans)
Secernentea B0495.5 33 34
  • 47.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G03200 33
  • 49.33 (n)
rice
(Oryza sativa)
Liliopsida Os.23695 33
Species where no ortholog for SPATA20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPATA20 Gene

ENSEMBL:
Gene Tree for SPATA20 (if available)
TreeFam:
Gene Tree for SPATA20 (if available)

Paralogs for SPATA20 Gene

(1) SIMAP similar genes for SPATA20 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SPATA20 Gene

genes like me logo Genes that share paralogs with SPATA20: view

No data available for Paralogs for SPATA20 Gene

Variants for SPATA20 Gene

Sequence variations from dbSNP and Humsavar for SPATA20 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000060209 -- 50,550,508(+) T/C intron_variant
rs1000443938 -- 50,547,841(+) T/C intron_variant
rs1000473717 -- 50,554,178(+) A/G intron_variant
rs1000475131 -- 50,547,570(+) C/T intron_variant
rs1000697110 -- 50,552,736(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA20 Gene

Variant ID Type Subtype PubMed ID
esv2625984 CNV deletion 19546169
nsv833477 CNV loss 17160897

Variation tolerance for SPATA20 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.12; 96.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA20 Gene

Disorders for SPATA20 Gene

Additional Disease Information for SPATA20

No disorders were found for SPATA20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA20 Gene

Publications for SPATA20 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Cloning and characterization of rat spermatid protein SSP411: a thioredoxin-like protein. (PMID: 15223837) Shi HJ … Chen CL (Journal of andrology 2004) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SPATA20 Gene

Sources for SPATA20 Gene

Content
Loading form....