Aliases for SPATA17 Gene

Aliases for SPATA17 Gene

  • Spermatogenesis Associated 17 2 3 5
  • Spermatogenesis-Associated Protein 17 3 4
  • IQ Motif Containing H 2 3
  • CFAP305 2 3
  • FAP305 2 3
  • MOT17 2 3
  • IQCH 2 3
  • Spermatogenesis-Related Protein 11 3
  • MSRG-11 3
  • SPATA17 5
  • MSRG11 3

External Ids for SPATA17 Gene

Previous GeneCards Identifiers for SPATA17 Gene

  • GC01P215871
  • GC01P217804
  • GC01P188479

Summaries for SPATA17 Gene

GeneCards Summary for SPATA17 Gene

SPATA17 (Spermatogenesis Associated 17) is a Protein Coding gene. Diseases associated with SPATA17 include Spermatogenic Failure, X-Linked, 1 and Ichthyosis, Congenital, Autosomal Recessive 11. Gene Ontology (GO) annotations related to this gene include calmodulin binding.

Additional gene information for SPATA17 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA17 Gene

Genomics for SPATA17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J217629 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 608.6 -0.4 -424 2.6 HNRNPL CREB1 ATF7 ZNF629 PRDM10 RFX1 POLR2A ZHX2 FOXA1 LARP7 SPATA17 GPATCH2 MN296931 ESRRG
GH01J217659 Enhancer 0.8 Ensembl ENCODE 17.9 +29.6 29574 2.6 CTCF FOXA1 RAD21 SP1 JUND CEBPB ZNF316 MAFF FOS SMC3 SPATA17 GPATCH2 piR-34974-002 SPATA17-AS1 RRP15
GH01J217561 Enhancer 0.8 Ensembl ENCODE 11.2 -68.8 -68823 2.6 CREB1 CTCF SP1 JUND CTBP1 FOS FOSL2 GATA3 DPF2 FOXA1 SPATA17 GPATCH2 MN296930 lnc-ESRRG-4 lnc-ESRRG-5 ESRRG
GH01J217574 Enhancer 0.7 ENCODE 10.9 -56.5 -56540 0.1 GATAD2A FOXA1 CEBPA CTBP1 FOXA2 ZNF217 KDM6A CREM MBD2 GATA3 MN296930 GPATCH2 SPATA17 lnc-ESRRG-4 lnc-ESRRG-5 ESRRG
GH01J217605 Enhancer 0.5 Ensembl 11.4 -25.9 -25923 0.4 FOXA1 NFE2 ZNF316 PKNOX1 MAFG CUX1 GATA3 MAFK NFE2L2 GPATCH2 SPATA17 lnc-ESRRG-4 piR-43107-027 ESRRG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA17

Top Transcription factor binding sites by QIAGEN in the SPATA17 gene promoter:
  • c-Jun
  • CUTL1
  • E2F
  • E2F-1
  • FOXO4
  • MIF-1
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a
  • RelA

Genomic Locations for SPATA17 Gene

Genomic Locations for SPATA17 Gene
chr1:217,631,324-217,871,696
(GRCh38/hg38)
Size:
240,373 bases
Orientation:
Plus strand
chr1:217,804,666-218,045,038
(GRCh37/hg19)
Size:
240,373 bases
Orientation:
Plus strand

Genomic View for SPATA17 Gene

Genes around SPATA17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA17 Gene

Proteins for SPATA17 Gene

  • Protein details for SPATA17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L03-SPT17_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 17
    Protein Accession:
    Q96L03
    Secondary Accessions:
    • A5D6N2

    Protein attributes for SPATA17 Gene

    Size:
    361 amino acids
    Molecular mass:
    43499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA17 Gene

Post-translational modifications for SPATA17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA17 Gene

No data available for DME Specific Peptides for SPATA17 Gene

Domains & Families for SPATA17 Gene

Gene Families for SPATA17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA17 Gene

Suggested Antigen Peptide Sequences for SPATA17 Gene

GenScript: Design optimal peptide antigens:
  • Spermatogenesis-related protein 11 (A5D6N2_HUMAN)
  • Spermatogenesis-associated protein 17 (SPT17_HUMAN)
genes like me logo Genes that share domains with SPATA17: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA17 Gene

Function for SPATA17 Gene

Phenotypes From GWAS Catalog for SPATA17 Gene

Gene Ontology (GO) - Molecular Function for SPATA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with SPATA17: view
genes like me logo Genes that share phenotypes with SPATA17: view

Animal Model Products

CRISPR Products

miRNA for SPATA17 Gene

miRTarBase miRNAs that target SPATA17

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA17 Gene

Localization for SPATA17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA17 gene
Compartment Confidence
nucleus 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPATA17: view

Pathways & Interactions for SPATA17 Gene

PathCards logo

SuperPathways for SPATA17 Gene

No Data Available

Interacting Proteins for SPATA17 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000355900 Q96L03-SPT17_HUMAN for SPATA17 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPATA17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA17 Gene

Drugs & Compounds for SPATA17 Gene

No Compound Related Data Available

Transcripts for SPATA17 Gene

mRNA/cDNA for SPATA17 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA17

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA17 Gene

No ASD Table

Relevant External Links for SPATA17 Gene

GeneLoc Exon Structure for
SPATA17

Expression for SPATA17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SPATA17 Gene

This gene is overexpressed in Testis (x26.8).

Protein differential expression in normal tissues from HIPED for SPATA17 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA17 Gene



Protein tissue co-expression partners for SPATA17 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA17

SOURCE GeneReport for Unigene cluster for SPATA17 Gene:

Hs.171130

Evidence on tissue expression from TISSUES for SPATA17 Gene

  • Liver(4.8)
  • Pancreas(3.7)
  • Blood(3.7)
  • Adrenal gland(2.7)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with SPATA17: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA17 Gene

Orthologs for SPATA17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPATA17 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPATA17 30 31
  • 87.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPATA17 30
  • 83.47 (n)
Mouse
(Mus musculus)
Mammalia Spata17 30 17 31
  • 77.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spata17 30
  • 76.64 (n)
Oppossum
(Monodelphis domestica)
Mammalia SPATA17 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SPATA17 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SPATA17 30 31
  • 67.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SPATA17 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spata17 30
  • 62.41 (n)
Zebrafish
(Danio rerio)
Actinopterygii spata17 30 31
  • 54.65 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Species where no ortholog for SPATA17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPATA17 Gene

ENSEMBL:
Gene Tree for SPATA17 (if available)
TreeFam:
Gene Tree for SPATA17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA17: view image

Paralogs for SPATA17 Gene

Pseudogenes.org Pseudogenes for SPATA17 Gene

genes like me logo Genes that share paralogs with SPATA17: view

No data available for Paralogs for SPATA17 Gene

Variants for SPATA17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA17 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs34652544 - p.Asn16Ser

Additional dbSNP identifiers (rs#s) for SPATA17 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPATA17 Gene

Variant ID Type Subtype PubMed ID
esv1000763 CNV insertion 20482838
esv1410169 CNV insertion 17803354
esv1474893 CNV deletion 17803354
esv2674631 CNV deletion 23128226
esv2722940 CNV deletion 23290073
esv2762166 CNV loss 21179565
esv3304574 CNV mobile element insertion 20981092
esv3305168 CNV mobile element insertion 20981092
esv3308331 CNV mobile element insertion 20981092
esv3322896 CNV insertion 20981092
esv3352301 CNV insertion 20981092
esv3396866 CNV insertion 20981092
esv3402578 CNV insertion 20981092
esv3546766 CNV deletion 23714750
esv3578434 CNV loss 25503493
esv3588849 CNV loss 21293372
esv3588850 CNV loss 21293372
esv3588851 CNV gain 21293372
esv3588853 CNV loss 21293372
esv8865 CNV loss 19470904
esv989721 CNV deletion 20482838
nsv1003999 CNV loss 25217958
nsv1005829 CNV gain 25217958
nsv1068863 CNV deletion 25765185
nsv1122447 CNV deletion 24896259
nsv1124604 CNV duplication 24896259
nsv1152188 CNV deletion 26484159
nsv468183 CNV loss 19166990
nsv472635 CNV novel sequence insertion 20440878
nsv477649 CNV novel sequence insertion 20440878
nsv477696 CNV novel sequence insertion 20440878
nsv523504 CNV loss 19592680
nsv549216 CNV loss 21841781
nsv549217 CNV loss 21841781
nsv945292 CNV duplication 23825009
nsv957430 CNV deletion 24416366

Variation tolerance for SPATA17 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA17 Gene

Disorders for SPATA17 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SPATA17 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPATA17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SPATA17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA17 Gene

Publications for SPATA17 Gene

  1. Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers. (PMID: 19680270) Nakabayashi K … Shirasawa S (Journal of human genetics 2009) 3 41
  2. A single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest. (PMID: 19483714) Miyamoto T … Sengoku K (Asian journal of andrology 2009) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells. (PMID: 16395525) Deng Y … Lu GX (Acta biochimica et biophysica Sinica 2006) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SPATA17 Gene

  • Signalway Proteins for SPATA17

Sources for SPATA17 Gene