Aliases for SPATA13 Gene

Aliases for SPATA13 Gene

  • Spermatogenesis Associated 13 2 3 5
  • APC-Stimulated Guanine Nucleotide Exchange Factor 2 3 4
  • Spermatogenesis-Associated Protein 13 3 4
  • ARHGEF29 2 3
  • ASEF2 2 3
  • Adenomatous Polyposis Coli Stimulated Exchange Factor 2 3
  • APC Stimulated Guanine Nucleotide Exchange Factor 2 2
  • FLJ31208 2
  • SPATA13 5
  • Asef2 4

External Ids for SPATA13 Gene

Previous GeneCards Identifiers for SPATA13 Gene

  • GC13P022532
  • GC13P023632
  • GC13P024734
  • GC13P005546
  • GC13P024554
  • GC13P023981
  • GC13P023983
  • GC13P024004
  • GC13P024006
  • GC13P024008
  • GC13P024010
  • GC13P023985
  • GC13P023987
  • GC13P023989
  • GC13P023991
  • GC13P023996
  • GC13P023998
  • GC13P024000
  • GC13P024002

Summaries for SPATA13 Gene

GeneCards Summary for SPATA13 Gene

SPATA13 (Spermatogenesis Associated 13) is a Protein Coding gene. Diseases associated with SPATA13 include Optic Atrophy 3, Autosomal Dominant and Dravet Syndrome. Among its related pathways are Regulation of RAC1 activity and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000273167.

UniProtKB/Swiss-Prot Summary for SPATA13 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA13 Gene

Genomics for SPATA13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J024269 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 256 +293.7 293722 7.3 BCLAF1 ZNF600 ZNF580 ATF2 KLF9 POLR2A ZIC2 YY1 MXD4 BCL11A SPATA13 HSALNG0095775 PARP4 MN298114-045 C1QTNF9 ENSG00000273167
GH13J023978 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.2 178 2 ZNF207 ZNF600 ZIC2 ZBTB10 SIN3A ZNF341 ELF1 SP2 SAP130 EBF1 ENSG00000228741 ENSG00000273167 SPATA13 lnc-C1QTNF9-9 C1QTNF9
GH13J024159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 250.1 +181.5 181499 3 ZNF600 POLR2A YY1 FEZF1 ZBTB7B SIN3A FOXA2 CTBP1 KLF9 RXRA HSALNG0095768 MIR2276 SPATA13 C1QTNF9 ENSG00000273167
GH13J024249 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 250.1 +272.8 272843 6.6 SPI1 MYC ATF2 RFX5 YY1 SPATA13-AS1 SPATA13 HSALNG0095773 C1QTNF9 ENSG00000273167
GH13J023995 Promoter/Enhancer 0.9 EPDnew Ensembl dbSUPER 250.4 +15.9 15899 0.6 GABPA ZBTB40 NR2F2 SPATA13 lnc-C1QTNF9-9 ENSG00000228741 ENSG00000273167 C1QTNF9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA13

Top Transcription factor binding sites by QIAGEN in the SPATA13 gene promoter:
  • AML1a
  • AREB6
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-3beta
  • HNF-4alpha1
  • Lhx3a
  • LHX3b
  • POU2F1
  • POU2F1a

Genomic Locations for SPATA13 Gene

Latest Assembly
chr13:23,979,802-24,307,074
(GRCh38/hg38)
Size:
327,273 bases
Orientation:
Plus strand

Previous Assembly
chr13:24,553,941-24,881,207
(GRCh37/hg19 by Entrez Gene)
Size:
327,267 bases
Orientation:
Plus strand

chr13:24,553,944-24,881,212
(GRCh37/hg19 by Ensembl)
Size:
327,269 bases
Orientation:
Plus strand

Genomic View for SPATA13 Gene

Genes around SPATA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA13 Gene

Proteins for SPATA13 Gene

  • Protein details for SPATA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N96-SPT13_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 13
    Protein Accession:
    Q96N96
    Secondary Accessions:
    • A2VEA9
    • A6NF85
    • B4DQB1
    • B4DSZ0
    • B4DVM8
    • J3KPJ7
    • J3KQH2
    • Q5VX68
    • Q6ZML1
    • Q8N873
    • Q8TEK6

    Protein attributes for SPATA13 Gene

    Size:
    652 amino acids
    Molecular mass:
    74820 Da
    Quaternary structure:
    • Interacts (via ABR and SH3 domain) with APC. The binding of APC enhances its GEF activity by relieving it from an autoinhibitory conformation, in which the ABR and SH3 domains are associated with the C-terminal tail. Interacts (via C-terminal tail) with PPP1R9B (via C-terminus). Interacts with RAC1.
    SequenceCaution:
    • Sequence=BAC04977.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATA13 Gene

neXtProt entry for SPATA13 Gene

Post-translational modifications for SPATA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA13 Gene

Domains & Families for SPATA13 Gene

Gene Families for SPATA13 Gene

Protein Domains for SPATA13 Gene

InterPro:
Blocks:
  • SH3 domain signature
  • Pleckstrin-like
  • DH domain
  • Protamine P1

Suggested Antigen Peptide Sequences for SPATA13 Gene

GenScript: Design optimal peptide antigens:
  • APC-stimulated guanine nucleotide exchange factor 2 (SPT13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96N96

UniProtKB/Swiss-Prot:

SPT13_HUMAN :
  • The C-terminal tail is required for its GEF activity.
Domain:
  • The C-terminal tail is required for its GEF activity.
genes like me logo Genes that share domains with SPATA13: view

Function for SPATA13 Gene

Molecular function for SPATA13 Gene

UniProtKB/Swiss-Prot Function:
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
UniProtKB/Swiss-Prot EnzymeRegulation:
Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

Phenotypes From GWAS Catalog for SPATA13 Gene

Gene Ontology (GO) - Molecular Function for SPATA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IMP 17145773
GO:0005515 protein binding IPI 17145773
GO:0042802 identical protein binding IPI --
genes like me logo Genes that share ontologies with SPATA13: view
genes like me logo Genes that share phenotypes with SPATA13: view

Animal Models for SPATA13 Gene

MGI Knock Outs for SPATA13:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPATA13 Gene

Localization for SPATA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA13 Gene

Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA13 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 19151759
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPATA13: view

Pathways & Interactions for SPATA13 Gene

genes like me logo Genes that share pathways with SPATA13: view

Pathways by source for SPATA13 Gene

2 BioSystems pathways for SPATA13 Gene
1 KEGG pathway for SPATA13 Gene
1 GeneGo (Thomson Reuters) pathway for SPATA13 Gene
  • G-protein signaling_Regulation of CDC42 activity

SIGNOR curated interactions for SPATA13 Gene

Activates:

Gene Ontology (GO) - Biological Process for SPATA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IMP 17145773
GO:0030032 lamellipodium assembly IMP 17599059
GO:0030334 regulation of cell migration IMP 17599059
GO:0046847 filopodium assembly IMP 17145773
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with SPATA13: view

Drugs & Compounds for SPATA13 Gene

No Compound Related Data Available

Transcripts for SPATA13 Gene

mRNA/cDNA for SPATA13 Gene

6 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPATA13

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - -
SP12:
SP13: - - - -
SP14:
SP15: -
SP16:
SP17:

ExUns: 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: - - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:
SP12: - - - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for SPATA13 Gene

GeneLoc Exon Structure for
SPATA13

Expression for SPATA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATA13 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPATA13 Gene



Protein tissue co-expression partners for SPATA13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA13

SOURCE GeneReport for Unigene cluster for SPATA13 Gene:

Hs.595391

mRNA Expression by UniProt/SwissProt for SPATA13 Gene:

Q96N96-SPT13_HUMAN
Tissue specificity: Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.

Evidence on tissue expression from TISSUES for SPATA13 Gene

  • Kidney(4.5)
  • Spleen(4.3)
  • Nervous system(4.2)
  • Lung(4.2)
  • Pancreas(3.6)
  • Intestine(2)
genes like me logo Genes that share expression patterns with SPATA13: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA13 Gene

Orthologs for SPATA13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPATA13 29 30
  • 99.4 (n)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 81 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia SPATA13 29
  • 79.18 (n)
-- 30
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Spata13 29 16 30
  • 76.84 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Spata13 29
  • 76.24 (n)
Cow
(Bos Taurus)
Mammalia LOC785769 29
  • 74.12 (n)
-- 30
  • 64 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SPATA13 29
  • 68.53 (n)
-- 30
  • 65 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 64 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485539 29
  • 63.44 (n)
Zebrafish
(Danio rerio)
Actinopterygii spata13 29 30
  • 56.89 (n)
OneToMany
Dr.14043 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7470 30
  • 34 (a)
OneToMany
Species where no ortholog for SPATA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPATA13 Gene

ENSEMBL:
Gene Tree for SPATA13 (if available)
TreeFam:
Gene Tree for SPATA13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA13: view image
Alliance of Genome Resources:
Additional Orthologs for SPATA13

Paralogs for SPATA13 Gene

(6) SIMAP similar genes for SPATA13 Gene using alignment to 6 proteins:

  • SPT13_HUMAN
  • E9PFR9_HUMAN
  • J3KQH2_HUMAN
  • J3KQJ8_HUMAN
  • Q5VX67_HUMAN
  • V9GZ16_HUMAN
genes like me logo Genes that share paralogs with SPATA13: view

Variants for SPATA13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA13 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs201402934 -- p.Arg89Trp
rs7330736 -- p.Arg20Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPATA13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPATA13 Gene

Variant ID Type Subtype PubMed ID
dgv1615n100 CNV gain 25217958
dgv3084n54 CNV gain 21841781
dgv3091n54 CNV loss 21841781
dgv929n106 CNV deletion 24896259
esv1137865 CNV insertion 17803354
esv1144168 CNV insertion 17803354
esv2242475 CNV deletion 18987734
esv2422202 CNV duplication 17116639
esv2422502 CNV duplication 17116639
esv2665633 CNV deletion 23128226
esv2669203 CNV deletion 23128226
esv2751136 CNV loss 17911159
esv2751137 CNV gain 17911159
esv28101 CNV gain 19812545
esv28977 CNV gain 19812545
esv28988 CNV loss 19812545
esv3366945 CNV duplication 20981092
esv3550185 CNV deletion 23714750
esv3550186 CNV deletion 23714750
esv3580576 CNV loss 25503493
esv3582215 CNV gain 25503493
esv3631536 CNV gain 21293372
esv3631540 CNV gain 21293372
esv3631541 CNV loss 21293372
esv3631542 CNV loss 21293372
esv3631545 CNV loss 21293372
esv3631546 CNV loss 21293372
esv3631547 CNV loss 21293372
esv3631548 CNV loss 21293372
esv3631549 CNV loss 21293372
esv3892310 CNV gain 25118596
esv3892311 CNV gain 25118596
esv5325 OTHER complex 18987735
esv9381 CNV loss 19470904
nsv1044867 CNV gain 25217958
nsv1049594 CNV loss 25217958
nsv1050731 CNV gain 25217958
nsv1051728 CNV gain 25217958
nsv1052089 CNV loss 25217958
nsv1069053 CNV deletion 25765185
nsv1070159 CNV deletion 25765185
nsv1078303 OTHER inversion 25765185
nsv1120011 CNV deletion 24896259
nsv1134290 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv455837 CNV gain 19166990
nsv455842 CNV gain 19166990
nsv507686 OTHER sequence alteration 20534489
nsv509499 CNV insertion 20534489
nsv516361 CNV loss 19592680
nsv525965 CNV gain 19592680
nsv561292 CNV loss 21841781
nsv561338 CNV gain 21841781
nsv561341 CNV loss 21841781
nsv561342 CNV gain 21841781
nsv832566 CNV gain 17160897
nsv832567 CNV loss 17160897
nsv974060 CNV duplication 23825009

Variation tolerance for SPATA13 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA13 Gene

Human Gene Mutation Database (HGMD)
SPATA13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA13
Leiden Open Variation Database (LOVD)
SPATA13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA13 Gene

Disorders for SPATA13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPATA13 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
optic atrophy 3, autosomal dominant
  • opa3
dravet syndrome
  • drvt
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPATA13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SPATA13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA13 Gene

Publications for SPATA13 Gene

  1. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H … Wang DW (Stroke 2010) 3 40
  2. Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. (PMID: 19151759) Sagara M … Akiyama T (Oncogene 2009) 3 4
  3. The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. (PMID: 19934221) Bristow JM … Webb DJ (Journal of cell science 2009) 3 4
  4. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. (PMID: 17145773) Hamann MJ … Billadeau DD (Molecular and cellular biology 2007) 3 4
  5. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. (PMID: 17599059) Kawasaki Y … Akiyama T (Oncogene 2007) 3 4

Products for SPATA13 Gene

Sources for SPATA13 Gene