Aliases for SPATA1 Gene

Aliases for SPATA1 Gene

  • Spermatogenesis Associated 1 2 3 5
  • Spermatogenesis-Associated Protein 1 3 4
  • Sperm-Specific Protein SP-2 3 4
  • SP-2 2 3
  • SPATA1 5
  • SPAP1 3

External Ids for SPATA1 Gene

Previous GeneCards Identifiers for SPATA1 Gene

  • GC01M085538
  • GC01P084109
  • GC01P084260
  • GC01P084394
  • GC01P084684
  • GC01P084744
  • GC01P084971

Summaries for SPATA1 Gene

GeneCards Summary for SPATA1 Gene

SPATA1 (Spermatogenesis Associated 1) is a Protein Coding gene.

Additional gene information for SPATA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPATA1 Gene

Genomics for SPATA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPATA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPATA1

Top Transcription factor binding sites by QIAGEN in the SPATA1 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • NF-AT3
  • NF-AT4
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for SPATA1 Gene

Genomic Locations for SPATA1 Gene
chr1:84,506,300-84,566,194
(GRCh38/hg38)
Size:
59,895 bases
Orientation:
Plus strand
chr1:84,971,974-85,031,877
(GRCh37/hg19)
Size:
59,904 bases
Orientation:
Plus strand

Genomic View for SPATA1 Gene

Genes around SPATA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA1 Gene

Proteins for SPATA1 Gene

  • Protein details for SPATA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VX52-SPAT1_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 1
    Protein Accession:
    Q5VX52
    Secondary Accessions:
    • A0A1W2PQB0
    • A0PJU9
    • Q0VDJ9
    • Q0VDK0
    • Q6P386
    • Q9HAR4

    Protein attributes for SPATA1 Gene

    Size:
    459 amino acids
    Molecular mass:
    52946 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for SPATA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA1 Gene

Post-translational modifications for SPATA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA1 Gene

No data available for DME Specific Peptides for SPATA1 Gene

Domains & Families for SPATA1 Gene

Gene Families for SPATA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA1 Gene

GenScript: Design optimal peptide antigens:
  • Sperm-specific protein SP-2 (SPAT1_HUMAN)
genes like me logo Genes that share domains with SPATA1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPATA1 Gene

Function for SPATA1 Gene

Phenotypes From GWAS Catalog for SPATA1 Gene

genes like me logo Genes that share phenotypes with SPATA1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA1 Gene

Localization for SPATA1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPATA1 Gene

Pathways & Interactions for SPATA1 Gene

PathCards logo

SuperPathways for SPATA1 Gene

No Data Available

Interacting Proteins for SPATA1 Gene

Gene Ontology (GO) - Biological Process for SPATA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA1 Gene

Drugs & Compounds for SPATA1 Gene

No Compound Related Data Available

Transcripts for SPATA1 Gene

mRNA/cDNA for SPATA1 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA1 Gene

No ASD Table

Relevant External Links for SPATA1 Gene

GeneLoc Exon Structure for
SPATA1

Expression for SPATA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA1 Gene

This gene is overexpressed in Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for SPATA1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA1 Gene



Protein tissue co-expression partners for SPATA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPATA1

SOURCE GeneReport for Unigene cluster for SPATA1 Gene:

Hs.584956
genes like me logo Genes that share expression patterns with SPATA1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA1 Gene

Orthologs for SPATA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPATA1 30
  • 99.49 (n)
Dog
(Canis familiaris)
Mammalia SPATA1 30
  • 89.55 (n)
Cow
(Bos Taurus)
Mammalia SPATA1 30
  • 87.34 (n)
Mouse
(Mus musculus)
Mammalia Spata1 30 17
  • 85.93 (n)
Rat
(Rattus norvegicus)
Mammalia Spata1 30
  • 83.69 (n)
Chicken
(Gallus gallus)
Aves SPATA1 30
  • 66.28 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spata1 30
  • 57.78 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101885834 30
  • 48.47 (n)
Species where no ortholog for SPATA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPATA1 Gene

ENSEMBL:
Gene Tree for SPATA1 (if available)
TreeFam:
Gene Tree for SPATA1 (if available)

Paralogs for SPATA1 Gene

No data available for Paralogs for SPATA1 Gene

Variants for SPATA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPATA1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
718265 Benign: not provided 84,555,086(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
723110 Benign: not provided 84,555,112(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
rs10493753 - p.Val175Leu

Additional dbSNP identifiers (rs#s) for SPATA1 Gene

Additional Variant Information for SPATA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SPATA1 Gene

Disorders for SPATA1 Gene

Additional Disease Information for SPATA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for SPATA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA1 Gene

Publications for SPATA1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for SPATA1 Gene

Sources for SPATA1 Gene