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Aliases for SPATA1 Gene

Aliases for SPATA1 Gene

  • Spermatogenesis Associated 1 2 3 5
  • Sperm-Specific Protein SP-2 3 4
  • Spermatogenesis-Associated Protein 1 3
  • SPAP1 3
  • SP-2 3

External Ids for SPATA1 Gene

Previous GeneCards Identifiers for SPATA1 Gene

  • GC01M085538
  • GC01P084109
  • GC01P084260
  • GC01P084394
  • GC01P084684
  • GC01P084744
  • GC01P084971

Summaries for SPATA1 Gene

GeneCards Summary for SPATA1 Gene

SPATA1 (Spermatogenesis Associated 1) is a Protein Coding gene.

Additional gene information for SPATA1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA1 Gene

Genomics for SPATA1 Gene

GeneHancer (GH) Regulatory Elements for SPATA1 Gene

Promoters and enhancers for SPATA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I084503 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 570.3 -0.5 -469 4.3 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 SPATA1 GNG5 BCL10 CTBS RPF1 MCOLN2
GH01I084618 Enhancer 1.5 Ensembl ENCODE dbSUPER 27 +113.9 113886 2.9 PKNOX1 ZFP64 SIN3A ZNF2 ZNF213 ZNF143 FOS SP3 ZC3H11A REST LINC01461 ENSG00000271576 SPATA1 CTBS GNG5 C1orf52 RPF1 SAMD13 MCOLN3 GC01M084581
GH01I084597 Enhancer 1 Ensembl ENCODE 23.9 +93.2 93189 3 ZBTB21 JUN BATF IRF4 RELA GTF3C2 FOSL1 ZFHX2 POLR2A NFATC1 SPATA1 GNG5 RPF1 CTBS GC01M084581 LINC01461
GH01I084572 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 9.9 +67.6 67589 2.8 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 CTBS SPATA1 GNG5 MCOLN2 PIR44908 GC01P084567
GH01I084630 Enhancer 1.3 Ensembl ENCODE dbSUPER 16.4 +127.2 127197 5.9 HDAC1 PKNOX1 CLOCK NEUROD1 MZF1 SIN3A RFX5 FOS RCOR1 ELF1 LINC01555 SPATA1 GNG5 RPF1 CTBS ENSG00000232622 LINC01461
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA1 gene promoter:

Genomic Locations for SPATA1 Gene

Genomic Locations for SPATA1 Gene
chr1:84,506,300-84,566,194
(GRCh38/hg38)
Size:
59,895 bases
Orientation:
Plus strand
chr1:84,971,974-85,031,877
(GRCh37/hg19)

Genomic View for SPATA1 Gene

Genes around SPATA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA1 Gene

Proteins for SPATA1 Gene

  • Protein details for SPATA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VX52-SPAT1_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 1
    Protein Accession:
    Q5VX52
    Secondary Accessions:
    • A0PJU9
    • Q0VDJ9
    • Q0VDK0
    • Q6P386
    • Q9HAR4

    Protein attributes for SPATA1 Gene

    Size:
    437 amino acids
    Molecular mass:
    50307 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG22047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI19642.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI19643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI27635.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH70205.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAM13069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA1 Gene

Post-translational modifications for SPATA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA1 Gene

Domains & Families for SPATA1 Gene

Gene Families for SPATA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA1: view

No data available for UniProtKB/Swiss-Prot for SPATA1 Gene

Function for SPATA1 Gene

genes like me logo Genes that share phenotypes with SPATA1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA1 Gene

Localization for SPATA1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPATA1 Gene

Pathways & Interactions for SPATA1 Gene

SuperPathways for SPATA1 Gene

No Data Available

Interacting Proteins for SPATA1 Gene

Selected Interacting proteins: Q5VX52-SPAT1_HUMAN for SPATA1 Gene via IID

Gene Ontology (GO) - Biological Process for SPATA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA1 Gene

Drugs & Compounds for SPATA1 Gene

No Compound Related Data Available

Transcripts for SPATA1 Gene

mRNA/cDNA for SPATA1 Gene

(11) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA1 Gene

Spermatogenesis associated 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA1 Gene

No ASD Table

Relevant External Links for SPATA1 Gene

GeneLoc Exon Structure for
SPATA1
ECgene alternative splicing isoforms for
SPATA1

Expression for SPATA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA1 Gene

This gene is overexpressed in Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for SPATA1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA1 Gene



Protein tissue co-expression partners for SPATA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA1 Gene:

SPATA1

SOURCE GeneReport for Unigene cluster for SPATA1 Gene:

Hs.584956
genes like me logo Genes that share expression patterns with SPATA1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA1 Gene

Orthologs for SPATA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA1 33
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia SPATA1 33
  • 89.55 (n)
cow
(Bos Taurus)
Mammalia SPATA1 33
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Spata1 33 16
  • 85.93 (n)
rat
(Rattus norvegicus)
Mammalia Spata1 33
  • 83.69 (n)
chicken
(Gallus gallus)
Aves SPATA1 33
  • 66.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia spata1 33
  • 57.78 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885834 33
  • 48.47 (n)
Species where no ortholog for SPATA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA1 Gene

ENSEMBL:
Gene Tree for SPATA1 (if available)
TreeFam:
Gene Tree for SPATA1 (if available)

Paralogs for SPATA1 Gene

No data available for Paralogs for SPATA1 Gene

Variants for SPATA1 Gene

Sequence variations from dbSNP and Humsavar for SPATA1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000019693 -- 84,530,081(+) C/T intron_variant
rs1000087909 -- 84,528,671(+) T/A intron_variant
rs1000090045 -- 84,510,811(+) C/T intron_variant
rs1000185189 -- 84,549,896(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000222999 -- 84,508,936(+) G/T intron_variant

Additional Variant Information for SPATA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SPATA1 Gene

Disorders for SPATA1 Gene

Additional Disease Information for SPATA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPATA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA1 Gene

Publications for SPATA1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for SPATA1 Gene

Sources for SPATA1 Gene

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