SPARCL1 Gene (Protein Coding)

SPARC Like 1

GC04M087473
GIFtS:
38
See more...

Aliases for SPARCL1 Gene

Aliases for SPARCL1 Gene

  • SPARC Like 1 2 3 5
  • High Endothelial Venule Protein 3 4
  • SPARC-Like Protein 1 3 4
  • MAST 9 3 4
  • Hevin 2 4
  • MAST9 2 3
  • Proliferation-Inducing Protein 33 3
  • SPARC-Like 1 (Mast9, Hevin) 2
  • SPARC-Like 1 (Hevin) 3
  • SPARCL1 5
  • PIG33 3
  • SC1 3

External Ids for SPARCL1 Gene

Previous GeneCards Identifiers for SPARCL1 Gene

  • GC04M088552
  • GC04M088696
  • GC04M088852
  • GC04M088751
  • GC04M088613
  • GC04M088394
  • GC04M084140

Summaries for SPARCL1 Gene

GeneCards Summary for SPARCL1 Gene

SPARCL1 (SPARC Like 1) is a Protein Coding gene. Diseases associated with SPARCL1 include Entropion. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is SPARC.

Gene Wiki entry for SPARCL1 Gene

Additional gene information for SPARCL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPARCL1 Gene

Genomics for SPARCL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SPARCL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J087523 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 269.3 +3.6 3608 8.1 ZSCAN16 MAFF ZNF316 MAFK HNF4A MAFG RAD21 REST SP7 SP1 SPARCL1 lnc-HSD17B11-3 DMP1 ENSG00000272856 MEPE piR-38352-421 NUDT9
GH04J087531 Enhancer 0.3 dbSUPER 256.5 -1.2 -1218 0.8 ZNF548 SPARCL1 RPL6P13 HSALNG0035714 DSPP
GH04J087521 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 14 +9.0 8975 1.4 FEZF1 ZNF395 ZNF639 EP300 EBF1 CTBP1 ZNF843 STAT3 TBP ZNF316 SPARCL1 DMP1 DSPP lnc-HSD17B11-3 piR-38352-421 NUDT9
GH04J087488 Enhancer 0.8 Ensembl dbSUPER 19.2 +40.9 40861 2.4 CEBPA RXRA ZBTB33 JUND NFE2 HNF4A FOXA1 RAD21 REST MAX SPARCL1 ENSG00000272856 piR-38352-421 lnc-HSD17B11-3 NUDT9
GH04J087506 Enhancer 0.8 Ensembl ENCODE dbSUPER 19.2 +23.6 23606 2.3 JUND CTCF BHLHE40 DACH1 CEBPB SPARCL1 HSD17B11 HSD17B13 lnc-HSD17B11-3 piR-38352-421 NUDT9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPARCL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPARCL1

Top Transcription factor binding sites by QIAGEN in the SPARCL1 gene promoter:
  • C/EBPalpha
  • Chx10
  • E47
  • FOXI1
  • FOXO4
  • GATA-1
  • HFH-3
  • HSF2
  • HTF
  • NF-1

Genomic Locations for SPARCL1 Gene

Latest Assembly
chr4:87,473,335-87,531,061
(GRCh38/hg38)
Size:
57,727 bases
Orientation:
Minus strand

Previous Assembly
chr4:88,394,487-88,450,528
(GRCh37/hg19 by Entrez Gene)
Size:
56,042 bases
Orientation:
Minus strand

chr4:88,394,487-88,452,213
(GRCh37/hg19 by Ensembl)
Size:
57,727 bases
Orientation:
Minus strand

Genomic View for SPARCL1 Gene

Genes around SPARCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPARCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPARCL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPARCL1 Gene

Proteins for SPARCL1 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SPARCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14515-SPRL1_HUMAN
    Recommended name:
    SPARC-like protein 1
    Protein Accession:
    Q14515
    Secondary Accessions:
    • B4E2Z0
    • E7ESU2
    • Q14800

    Protein attributes for SPARCL1 Gene

    Size:
    664 amino acids
    Molecular mass:
    75208 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPARCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPARCL1 Gene

Protein Expression for SPARCL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SPARCL1 Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Thr31, Thr40, Ser44, Asn169, Asn176, Asn196, Thr116, Asn280, Thr331, Thr398, Asn412, and Asn476
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SPRL1_HUMAN (728)

Other Protein References for SPARCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for SPARCL1

Assay products for research

  • Boster Bio ELISA Kits for SPARCL1

No data available for DME Specific Peptides for SPARCL1 Gene

Domains & Families for SPARCL1 Gene

Gene Families for SPARCL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPARCL1 Gene

InterPro:
Blocks:
  • Osteonectin-like
  • Follistatin-like, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SPARCL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52396, highly similar to SPARC-like protein 1 (B4E2Z0_HUMAN)
  • SPARC-like 1 (Hevin) (Q8N4S1_HUMAN)
  • MAST 9 (SPRL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14515

UniProtKB/Swiss-Prot:

SPRL1_HUMAN :
  • Belongs to the SPARC family.
Family:
  • Belongs to the SPARC family.
genes like me logo Genes that share domains with SPARCL1: view

Function for SPARCL1 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for SPARCL1 Gene

Gene Ontology (GO) - Molecular Function for SPARCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 20926826
GO:0005518 collagen binding IBA 21873635
GO:0046872 metal ion binding IEA --
GO:0050840 extracellular matrix binding IBA 21873635
genes like me logo Genes that share ontologies with SPARCL1: view
genes like me logo Genes that share phenotypes with SPARCL1: view

Animal Models for SPARCL1 Gene

MGI Knock Outs for SPARCL1:

Animal Models for research

miRNA for SPARCL1 Gene

miRTarBase miRNAs that target SPARCL1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPARCL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPARCL1 Gene

Localization for SPARCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPARCL1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPARCL1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPARCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005615 extracellular space IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0062023 collagen-containing extracellular matrix IEA --
GO:0098978 glutamatergic synapse IEA --
genes like me logo Genes that share ontologies with SPARCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPARCL1 Gene

Pathways & Interactions for SPARCL1 Gene

PathCards logo

SuperPathways for SPARCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPARCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0048856 anatomical structure development IBA 21873635
GO:0099560 synaptic membrane adhesion IEA --
genes like me logo Genes that share ontologies with SPARCL1: view

No data available for Pathways by source and SIGNOR curated interactions for SPARCL1 Gene

Drugs & Compounds for SPARCL1 Gene

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  1. Drug products for research

(1) Drugs for SPARCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SPARCL1: view

Transcripts for SPARCL1 Gene

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mRNA/cDNA for SPARCL1 Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPARCL1

Alternative Splicing Database (ASD) splice patterns (SP) for SPARCL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2: -
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7: - - - - - - - -

Relevant External Links for SPARCL1 Gene

GeneLoc Exon Structure for
SPARCL1

Expression for SPARCL1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPARCL1 Gene

mRNA expression in normal human tissues for SPARCL1 Gene
mRNA expression by BioGPS for SPARCL1 GenemRNA expression by GTEx for SPARCL1 Gene

Protein differential expression in normal tissues from HIPED for SPARCL1 Gene

This gene is overexpressed in Cerebrospinal fluid (28.2), Vitreous humor (10.3), Serum (8.5), and Plasma (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPARCL1 Gene



Protein tissue co-expression partners for SPARCL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPARCL1

SOURCE GeneReport for Unigene cluster for SPARCL1 Gene:

Hs.62886

mRNA Expression by UniProt/SwissProt for SPARCL1 Gene:

Q14515-SPRL1_HUMAN
Tissue specificity: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SPARCL1 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Heart(4.3)
  • Intestine(4.3)
  • Bone marrow(4.2)
  • Stomach(3.6)
  • Eye(3.4)
  • Spleen(3.4)
  • Kidney(3.2)
  • Muscle(3.1)
  • Skin(2.6)
  • Gall bladder(2.5)
  • Lymph node(2.4)
  • Adrenal gland(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SPARCL1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPARCL1 Gene

Orthologs for SPARCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPARCL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SPARCL1 30 31
  • 99 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SPARCL1 30 31
  • 85.47 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SPARCL1 30 31
  • 82.46 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Sparcl1 30
  • 74.62 (n)
Mouse
(Mus musculus)
 Mammalia Sparcl1 30 17 31
  • 74.35 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SPARCL1 31
  • 39 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SPARCL1 31
  • 32 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii sparcl1 31
  • 33 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000305 30
  • 49.03 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta BM-40-SPARC 30 31
  • 47.78 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea ost-1 30 31
  • 53.88 (n)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 38 (a)
 OneToMany
Species where no ortholog for SPARCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SPARCL1 Gene

ENSEMBL:
Gene Tree for SPARCL1 (if available)
TreeFam:
Gene Tree for SPARCL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPARCL1: view image

Paralogs for SPARCL1 Gene

Paralogs for SPARCL1 Gene

(1) SIMAP similar genes for SPARCL1 Gene using alignment to 10 proteins:

  • SPRL1_HUMAN
  • B4E2Z0_HUMAN
  • C9JJR8_HUMAN
  • D6RA29_HUMAN
  • E7EU82_HUMAN
  • E9PC64_HUMAN
  • F5H1Y9_HUMAN
  • F5H331_HUMAN
  • F5H4Y3_HUMAN
  • Q8N4S1_HUMAN
genes like me logo Genes that share paralogs with SPARCL1: view

Variants for SPARCL1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPARCL1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1049544 - p.His106Asp
rs1130643 - p.Thr419Ala
rs13051 - p.Ala49Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPARCL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPARCL1 Gene

Variant ID Type Subtype PubMed ID
esv3601276 CNV loss 21293372
esv3601278 CNV loss 21293372
esv3601279 CNV loss 21293372
nsv1002789 CNV loss 25217958
nsv1011882 CNV gain 25217958

Variation tolerance for SPARCL1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPARCL1 Gene

Human Gene Mutation Database (HGMD)
SPARCL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPARCL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPARCL1 Gene

Disorders for SPARCL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPARCL1 Gene - From: COP

Disorder Aliases PubMed IDs
entropion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPARCL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SPARCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPARCL1 Gene

Publications for SPARCL1 Gene

  1. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (PMID: 7600298) Girard JP … Springer TA (Immunity 1995) 2 3 4 23
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 41
  3. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PMID: 18384059) Kähler AK … Andreassen OA (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41
  4. Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. (PMID: 17825989) Scalabrini D … Galimberti D (Neuroscience letters 2007) 3 41
  5. Matricellular hevin regulates decorin production and collagen assembly. (PMID: 16844696) Sullivan MM … Sage EH (The Journal of biological chemistry 2006) 2 3

ExternalLinks

View latest publications for SPARCL1 gene in Mastermind

Products for SPARCL1 Gene

Sources for SPARCL1 Gene