Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPARCL1 Gene

Aliases for SPARCL1 Gene

  • SPARC Like 1 2 3 5
  • High Endothelial Venule Protein 3 4
  • MAST 9 3 4
  • Hevin 2 4
  • Proliferation-Inducing Protein 33 3
  • SPARC-Like 1 (Mast9, Hevin) 2
  • SPARC-Like 1 (Hevin) 3
  • SPARC-Like Protein 1 3
  • MAST9 3
  • PIG33 3
  • SC1 3

External Ids for SPARCL1 Gene

Previous GeneCards Identifiers for SPARCL1 Gene

  • GC04M088552
  • GC04M088696
  • GC04M088852
  • GC04M088751
  • GC04M088613
  • GC04M088394
  • GC04M084140

Summaries for SPARCL1 Gene

GeneCards Summary for SPARCL1 Gene

SPARCL1 (SPARC Like 1) is a Protein Coding gene. Diseases associated with SPARCL1 include Klatskin's Tumor. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is SPARC.

Gene Wiki entry for SPARCL1 Gene

Additional gene information for SPARCL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPARCL1 Gene

Genomics for SPARCL1 Gene

GeneHancer (GH) Regulatory Elements for SPARCL1 Gene

Promoters and enhancers for SPARCL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I087524 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 569.5 +2.9 2877 6.6 HLF REST RAD21 NR2F2 YY1 CBX5 ZSCAN16 SCRT2 HNF4A PRDM10 SPARCL1 DMP1 ENSG00000272856 MEPE LOC105377322
GH04I087531 Enhancer 0.4 dbSUPER 556.6 -1.2 -1218 0.8 MITF ZNF548 SPARCL1 RPL6P13 DSPP
GH04I087520 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +9.6 9557 2.6 PKNOX1 ZSCAN4 INSM2 FEZF1 ZNF366 ZSCAN5C ZNF350 ATF7 FOS ZNF362 LOC105377322 SPARCL1 DMP1 DSPP
GH04I087488 Enhancer 0.7 dbSUPER 19.2 +40.8 40824 2.8 FOXA2 MAX CEBPG RAD21 YY1 HNF4G NFE2 RXRA HLF CEBPB SPARCL1 ENSG00000272856 LOC105377321 LOC105377322
GH04I087555 Enhancer 0.7 Ensembl ENCODE 17.6 -25.0 -25028 1.2 ZNF639 SP1 JUND NFE2 FOSL2 FOS SPARCL1 DSPP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPARCL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPARCL1 gene promoter:

Genomic Locations for SPARCL1 Gene

Genomic Locations for SPARCL1 Gene
57,732 bases
Minus strand

Genomic View for SPARCL1 Gene

Genes around SPARCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPARCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPARCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPARCL1 Gene

Proteins for SPARCL1 Gene

  • Protein details for SPARCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPARC-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E2Z0
    • E7ESU2
    • Q14800

    Protein attributes for SPARCL1 Gene

    664 amino acids
    Molecular mass:
    75208 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPARCL1 Gene


neXtProt entry for SPARCL1 Gene

Post-translational modifications for SPARCL1 Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at isoforms=31, isoforms=40, isoforms=44, isoforms=116, isoforms=2169, isoforms=2176, posLast=196196, isoforms=2280, isoforms=2331, isoforms=2398, isoforms=2412, and isoforms=2476
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SPARCL1 (SPARC-like 1/SPARCL1)
  • Abcam antibodies for SPARCL1

Assay Products

  • Cloud-Clone Corp. Assay Kits for SPARCL1

No data available for DME Specific Peptides for SPARCL1 Gene

Domains & Families for SPARCL1 Gene

Gene Families for SPARCL1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SPARCL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPARC family.
  • Belongs to the SPARC family.
genes like me logo Genes that share domains with SPARCL1: view

Function for SPARCL1 Gene

Phenotypes From GWAS Catalog for SPARCL1 Gene

Gene Ontology (GO) - Molecular Function for SPARCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 20926826
GO:0005518 collagen binding IBA --
GO:0046872 metal ion binding IEA --
GO:0050840 extracellular matrix binding IBA --
genes like me logo Genes that share ontologies with SPARCL1: view
genes like me logo Genes that share phenotypes with SPARCL1: view

Animal Models for SPARCL1 Gene

MGI Knock Outs for SPARCL1:

Animal Model Products

CRISPR Products

miRNA for SPARCL1 Gene

miRTarBase miRNAs that target SPARCL1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPARCL1 Gene

Localization for SPARCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPARCL1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPARCL1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for SPARCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 27068509
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space HDA,IDA 16502470
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with SPARCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPARCL1 Gene

Pathways & Interactions for SPARCL1 Gene

SuperPathways for SPARCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPARCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0048856 anatomical structure development IBA --
genes like me logo Genes that share ontologies with SPARCL1: view

No data available for Pathways by source and SIGNOR curated interactions for SPARCL1 Gene

Drugs & Compounds for SPARCL1 Gene

(1) Drugs for SPARCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SPARCL1: view

Transcripts for SPARCL1 Gene

Unigene Clusters for SPARCL1 Gene

SPARC-like 1 (hevin):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPARCL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: -
SP3: - - - -
SP4: -
SP6: -
SP7: - - - - - - - -

Relevant External Links for SPARCL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPARCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPARCL1 Gene

Protein differential expression in normal tissues from HIPED for SPARCL1 Gene

This gene is overexpressed in Cerebrospinal fluid (28.2), Vitreous humor (10.3), Serum (8.5), and Plasma (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPARCL1 Gene

Protein tissue co-expression partners for SPARCL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPARCL1 Gene:


SOURCE GeneReport for Unigene cluster for SPARCL1 Gene:


mRNA Expression by UniProt/SwissProt for SPARCL1 Gene:

Tissue specificity: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SPARCL1 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Heart(4.1)
  • Bone marrow(4)
  • Intestine(4)
  • Stomach(3.4)
  • Spleen(3.1)
  • Eye(2.7)
  • Kidney(2.6)
  • Gall bladder(2.5)
  • Muscle(2.4)
  • Lymph node(2.3)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SPARCL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPARCL1 Gene

Orthologs for SPARCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPARCL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPARCL1 33 34
  • 99 (n)
(Canis familiaris)
Mammalia SPARCL1 33 34
  • 85.47 (n)
(Bos Taurus)
Mammalia SPARCL1 33 34
  • 82.46 (n)
(Rattus norvegicus)
Mammalia Sparcl1 33
  • 74.62 (n)
(Mus musculus)
Mammalia Sparcl1 33 16 34
  • 74.35 (n)
(Ornithorhynchus anatinus)
Mammalia SPARCL1 34
  • 39 (a)
(Gallus gallus)
Aves SPARCL1 34
  • 32 (a)
(Danio rerio)
Actinopterygii sparcl1 34
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000305 33
  • 49.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta BM-40-SPARC 33 34
  • 47.78 (n)
(Caenorhabditis elegans)
Secernentea ost-1 33 34
  • 53.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for SPARCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPARCL1 Gene

Gene Tree for SPARCL1 (if available)
Gene Tree for SPARCL1 (if available)

Paralogs for SPARCL1 Gene

Paralogs for SPARCL1 Gene

(1) SIMAP similar genes for SPARCL1 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SPARCL1: view

Variants for SPARCL1 Gene

Sequence variations from dbSNP and Humsavar for SPARCL1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000005938 -- 87,512,495(-) G/T intron_variant
rs1000040777 -- 87,506,978(-) TTTTTT/TTTTTTT intron_variant
rs10001608 -- 87,516,558(-) T/C intron_variant
rs1000242060 -- 87,506,229(-) C/A intron_variant
rs1000303332 -- 87,499,632(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPARCL1 Gene

Variant ID Type Subtype PubMed ID
esv3601276 CNV loss 21293372
esv3601278 CNV loss 21293372
esv3601279 CNV loss 21293372
nsv1002789 CNV loss 25217958
nsv1011882 CNV gain 25217958

Variation tolerance for SPARCL1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPARCL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPARCL1 Gene

Disorders for SPARCL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPARCL1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
klatskin's tumor
  • hilar cholangiocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPARCL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPARCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPARCL1 Gene

Publications for SPARCL1 Gene

  1. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (PMID: 7600298) Girard JP … Springer TA (Immunity 1995) 2 3 4 22 58
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  3. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PMID: 18384059) Kähler AK … Andreassen OA (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  4. Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. (PMID: 17825989) Scalabrini D … Galimberti D (Neuroscience letters 2007) 3 44 58
  5. Matricellular hevin regulates decorin production and collagen assembly. (PMID: 16844696) Sullivan MM … Sage EH (The Journal of biological chemistry 2006) 2 3 58

Products for SPARCL1 Gene

Sources for SPARCL1 Gene

Loading form....