Aliases for SPARC Gene
External Ids for SPARC Gene
Previous HGNC Symbols for SPARC Gene
Previous GeneCards Identifiers for SPARC Gene
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
GeneCards Summary for SPARC Gene
SPARC (Secreted Protein Acidic And Cysteine Rich) is a Protein Coding gene. Diseases associated with SPARC include Osteogenesis Imperfecta, Type Xvii and Osteogenesis Imperfecta, Type Iv. Among its related pathways are Degradation of the extracellular matrix and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPARCL1.
UniProtKB/Swiss-Prot Summary for SPARC Gene
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.