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Aliases for SPANXN4 Gene

Aliases for SPANXN4 Gene

  • SPANX Family Member N4 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 9 2 3
  • Nuclear-Associated Protein SPAN-Xn4 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N4 3
  • SPANX Family, Member N4 2
  • SPANX-N4 4
  • CT11.9 3

External Ids for SPANXN4 Gene

Previous GeneCards Identifiers for SPANXN4 Gene

  • GC0XP141942
  • GC0XP142113
  • GC0XP131217

Summaries for SPANXN4 Gene

Entrez Gene Summary for SPANXN4 Gene

  • This gene represents one of several duplicated family members that are located on the X chromosome. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. [provided by RefSeq, Sep 2009]

GeneCards Summary for SPANXN4 Gene

SPANXN4 (SPANX Family Member N4) is a Protein Coding gene. An important paralog of this gene is SPANXN3.

Additional gene information for SPANXN4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN4 Gene

Genomics for SPANXN4 Gene

GeneHancer (GH) Regulatory Elements for SPANXN4 Gene

Promoters and enhancers for SPANXN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI143025 Promoter 0.5 EPDnew 550.8 0.0 -6 0.1 SPANXN4 GC0XP142882
GH0XI142977 Enhancer 0.7 ENCODE 0.2 -47.8 -47849 1.4 PKNOX1 EBF1 BATF IRF4 POLR2A NFATC1 ATF7 ETV6 IKZF2 RUNX3 SPANXN4 GC0XP142882
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPANXN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPANXN4 gene promoter:

Genomic Locations for SPANXN4 Gene

Genomic Locations for SPANXN4 Gene
8,785 bases
Plus strand

Genomic View for SPANXN4 Gene

Genes around SPANXN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN4 Gene

Proteins for SPANXN4 Gene

  • Protein details for SPANXN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N4
    Protein Accession:
    Secondary Accessions:
    • Q0ZNK6
    • Q5W0S6

    Protein attributes for SPANXN4 Gene

    99 amino acids
    Molecular mass:
    11168 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH71622.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SPANXN4 Gene

Post-translational modifications for SPANXN4 Gene

No Post-translational modifications

Other Protein References for SPANXN4 Gene

No data available for DME Specific Peptides for SPANXN4 Gene

Domains & Families for SPANXN4 Gene

Gene Families for SPANXN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXN4 Gene


Suggested Antigen Peptide Sequences for SPANXN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN4: view

Function for SPANXN4 Gene

Phenotypes From GWAS Catalog for SPANXN4 Gene

genes like me logo Genes that share phenotypes with SPANXN4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXN4 Gene

Localization for SPANXN4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXN4 gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPANXN4 Gene

Pathways & Interactions for SPANXN4 Gene

SuperPathways for SPANXN4 Gene

No Data Available

Interacting Proteins for SPANXN4 Gene

Selected Interacting proteins: Q5MJ08-SPXN4_HUMAN for SPANXN4 Gene via IID

Gene Ontology (GO) - Biological Process for SPANXN4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN4 Gene

Drugs & Compounds for SPANXN4 Gene

No Compound Related Data Available

Transcripts for SPANXN4 Gene

mRNA/cDNA for SPANXN4 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN4 Gene

SPANX family, member N4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN4 Gene

No ASD Table

Relevant External Links for SPANXN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXN4 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN4 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for SPANXN4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPANXN4 Gene

Protein tissue co-expression partners for SPANXN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPANXN4 Gene:


SOURCE GeneReport for Unigene cluster for SPANXN4 Gene:

genes like me logo Genes that share expression patterns with SPANXN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXN4 Gene

Orthologs for SPANXN4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740280 33
  • 98.32 (n)
  • 63 (a)
Species where no ortholog for SPANXN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN4 Gene

Gene Tree for SPANXN4 (if available)
Gene Tree for SPANXN4 (if available)

Paralogs for SPANXN4 Gene

Paralogs for SPANXN4 Gene

(4) SIMAP similar genes for SPANXN4 Gene using alignment to 1 proteins: Pseudogenes for SPANXN4 Gene

genes like me logo Genes that share paralogs with SPANXN4: view

Variants for SPANXN4 Gene

Sequence variations from dbSNP and Humsavar for SPANXN4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs483352701 uncertain-significance, not provided 143,034,115(+) A/G coding_sequence_variant, missense_variant
rs1000189910 -- 143,029,464(+) T/G intron_variant
rs1000766408 -- 143,036,431(+) T/C genic_downstream_transcript_variant, intron_variant
rs1001344676 -- 143,038,182(+) G/T genic_downstream_transcript_variant, intron_variant
rs1001780497 -- 143,030,604(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN4 Gene

Variant ID Type Subtype PubMed ID
esv2664441 CNV deletion 23128226

Variation tolerance for SPANXN4 Gene

Gene Damage Index Score: 3.28; 52.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPANXN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN4 Gene

Disorders for SPANXN4 Gene

Additional Disease Information for SPANXN4

No disorders were found for SPANXN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN4 Gene

Publications for SPANXN4 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N … Larionov V (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4 58
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook VA … Herr JC (Molecular human reproduction 2006) 2 3 58
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 44 58
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D … Mitchell GF (BMC medical genetics 2007) 44 58

Products for SPANXN4 Gene

Sources for SPANXN4 Gene

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