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Aliases for SPANXN1 Gene

Aliases for SPANXN1 Gene

  • SPANX Family Member N1 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 6 2 3
  • Nuclear-Associated Protein SPAN-Xn1 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N1 3
  • SPANX Family, Member N1 2
  • SPANX-N1 4
  • CT11.6 3

External Ids for SPANXN1 Gene

Previous GeneCards Identifiers for SPANXN1 Gene

  • GC0XP144137
  • GC0XP144328
  • GC0XP133307

Summaries for SPANXN1 Gene

Entrez Gene Summary for SPANXN1 Gene

  • This gene represents one of several duplicated family members that are located on chromosome X. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. [provided by RefSeq, May 2010]

GeneCards Summary for SPANXN1 Gene

SPANXN1 (SPANX Family Member N1) is a Protein Coding gene. An important paralog of this gene is SPANXN5.

Additional gene information for SPANXN1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN1 Gene

Genomics for SPANXN1 Gene

GeneHancer (GH) Regulatory Elements for SPANXN1 Gene

Promoters and enhancers for SPANXN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI145247 Promoter 0.5 EPDnew 550.8 +0.4 379 0.1 SPANXN1 GC0XM145354
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPANXN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPANXN1 gene promoter:

Genomic Locations for SPANXN1 Gene

Genomic Locations for SPANXN1 Gene
9,381 bases
Plus strand

Genomic View for SPANXN1 Gene

Genes around SPANXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN1 Gene

Proteins for SPANXN1 Gene

  • Protein details for SPANXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N1
    Protein Accession:

    Protein attributes for SPANXN1 Gene

    72 amino acids
    Molecular mass:
    8263 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN1 Gene

Post-translational modifications for SPANXN1 Gene

No Post-translational modifications

Other Protein References for SPANXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN1 Gene

Domains & Families for SPANXN1 Gene

Gene Families for SPANXN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXN1 Gene


Suggested Antigen Peptide Sequences for SPANXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN1: view

Function for SPANXN1 Gene

Phenotypes From GWAS Catalog for SPANXN1 Gene

Phenotypes for SPANXN1 Gene

GenomeRNAi human phenotypes for SPANXN1:
genes like me logo Genes that share phenotypes with SPANXN1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPANXN1 Gene

Localization for SPANXN1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXN1 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPANXN1 Gene

Pathways & Interactions for SPANXN1 Gene

SuperPathways for SPANXN1 Gene

No Data Available

Interacting Proteins for SPANXN1 Gene

Gene Ontology (GO) - Biological Process for SPANXN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN1 Gene

Drugs & Compounds for SPANXN1 Gene

No Compound Related Data Available

Transcripts for SPANXN1 Gene

mRNA/cDNA for SPANXN1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN1 Gene

No ASD Table

Relevant External Links for SPANXN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXN1 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN1 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for SPANXN1 Gene

This gene is overexpressed in Amniocyte (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPANXN1 Gene

Protein tissue co-expression partners for SPANXN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPANXN1 Gene:


SOURCE GeneReport for Unigene cluster for SPANXN1 Gene:

genes like me logo Genes that share expression patterns with SPANXN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXN1 Gene

Orthologs for SPANXN1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPANXN1 34
  • 97 (a)
Species where no ortholog for SPANXN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN1 Gene

Gene Tree for SPANXN1 (if available)
Gene Tree for SPANXN1 (if available)

Paralogs for SPANXN1 Gene

Paralogs for SPANXN1 Gene

(12) SIMAP similar genes for SPANXN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN1: view

Variants for SPANXN1 Gene

Sequence variations from dbSNP and Humsavar for SPANXN1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002717106 -- 145,256,209(+) T/C downstream_transcript_variant
rs1006685943 -- 145,246,670(+) G/A upstream_transcript_variant
rs1009878570 -- 145,256,122(+) G/A 3_prime_UTR_variant
rs1036600131 -- 145,246,596(+) C/A/G upstream_transcript_variant
rs11094465 -- 145,248,541(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN1 Gene

Variant ID Type Subtype PubMed ID
nsv522897 CNV gain 19592680
dgv537n21 CNV loss 19592680

Variation tolerance for SPANXN1 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPANXN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN1 Gene

Disorders for SPANXN1 Gene

Additional Disease Information for SPANXN1

No disorders were found for SPANXN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN1 Gene

Publications for SPANXN1 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N … Larionov V (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4 58
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook VA … Herr JC (Molecular human reproduction 2006) 2 3 58
  3. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 44 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  5. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N … Larionov V (Genome research 2005) 4 58

Products for SPANXN1 Gene

Sources for SPANXN1 Gene

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