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Aliases for SPANXD Gene

Aliases for SPANXD Gene

  • SPANX Family Member D 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 4 2 3
  • Nuclear-Associated Protein SPAN-Xd 3 4
  • Cancer/Testis Antigen 11.4 3 4
  • SPANX Family, Member E 2 3
  • SPANX-D 3 4
  • SPANXE 3 4
  • CT11.4 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member D 3
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member E 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome D 3
  • Nuclear-Associated Protein SPAN-Xe 3
  • SPANX Family, Member D 2
  • DJ171K16.1 3
  • SPANX-E 3
  • SPANX-C 3

External Ids for SPANXD Gene

Previous HGNC Symbols for SPANXD Gene


Previous GeneCards Identifiers for SPANXD Gene

  • GC0XU990341
  • GC0XM137643
  • GC0XM138718
  • GC0XM139479
  • GC0XM140511
  • GC0XM140613
  • GC0XM140786

Summaries for SPANXD Gene

Entrez Gene Summary for SPANXD Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]

GeneCards Summary for SPANXD Gene

SPANXD (SPANX Family Member D) is a Protein Coding gene. An important paralog of this gene is SPANXC.

Additional gene information for SPANXD Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXD Gene

Genomics for SPANXD Gene

GeneHancer (GH) Regulatory Elements for SPANXD Gene

Promoters and enhancers for SPANXD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI141698 Promoter 0.5 EPDnew 550.8 0.0 -24 0.1 SPANXD GC0XM141718
GH0XI141699 Promoter 0.5 EPDnew 550.8 +0.3 254 0.1 SPANXD GC0XP141632
GH0XI141651 Enhancer 0.4 ENCODE 0.2 +46.5 46466 0.9 POLR2A CEBPB EP300 GC0XP141632 SPANXD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPANXD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPANXD gene promoter:

Genomic Locations for SPANXD Gene

Genomic Locations for SPANXD Gene
1,339 bases
Minus strand

Genomic View for SPANXD Gene

Genes around SPANXD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXD Gene

Proteins for SPANXD Gene

  • Protein details for SPANXD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome D
    Protein Accession:
    Secondary Accessions:
    • Q5JWI1

    Protein attributes for SPANXD Gene

    97 amino acids
    Molecular mass:
    11029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXD Gene

Post-translational modifications for SPANXD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXD Gene

Domains & Families for SPANXD Gene

Gene Families for SPANXD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXD Gene


Suggested Antigen Peptide Sequences for SPANXD Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXD: view

Function for SPANXD Gene

Gene Ontology (GO) - Molecular Function for SPANXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXD: view
genes like me logo Genes that share phenotypes with SPANXD: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXD Gene

Localization for SPANXD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXD Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXD gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPANXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,HDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXD: view

Pathways & Interactions for SPANXD Gene

SuperPathways for SPANXD Gene

No Data Available

Interacting Proteins for SPANXD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359546 Q9BXN6-SPNXD_HUMAN for SPANXD Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for SPANXD Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXD Gene

Drugs & Compounds for SPANXD Gene

No Compound Related Data Available

Transcripts for SPANXD Gene


(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXD Gene

SPANX family, member D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXD Gene

No ASD Table

Relevant External Links for SPANXD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXD Gene

mRNA differential expression in normal tissues according to GTEx for SPANXD Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of SPANXD Gene:


SOURCE GeneReport for Unigene cluster for SPANXD Gene:


mRNA Expression by UniProt/SwissProt for SPANXD Gene:

Tissue specificity: Detected in testis, sperm and a melanoma cell line.
genes like me logo Genes that share expression patterns with SPANXD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXD Gene

Orthologs for SPANXD Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 57 (a)
Species where no ortholog for SPANXD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXD Gene

Gene Tree for SPANXD (if available)
Gene Tree for SPANXD (if available)

Paralogs for SPANXD Gene

Paralogs for SPANXD Gene

genes like me logo Genes that share paralogs with SPANXD: view

Variants for SPANXD Gene

Sequence variations from dbSNP and Humsavar for SPANXD Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1059178 -- 141,697,584(-) A/C coding_sequence_variant, missense_variant
rs1059179 -- 141,697,582(-) A/C/G coding_sequence_variant, missense_variant, synonymous_variant
rs137928270 -- 141,697,655(-) G/A/C coding_sequence_variant, missense_variant
rs138079856 -- 141,697,487(-) A/G coding_sequence_variant, missense_variant
rs138515427 -- 141,697,166(-) C/G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXD Gene

Variant ID Type Subtype PubMed ID
esv25564 CNV gain+loss 19812545
esv2758896 CNV gain+loss 17122850
nsv471606 CNV gain 15918152
nsv9984 CNV gain 18304495

Variation tolerance for SPANXD Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPANXD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXD Gene

Disorders for SPANXD Gene

Additional Disease Information for SPANXD

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPANXD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXD Gene

Publications for SPANXD Gene

  1. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S … Carrell D (Systems biology in reproductive medicine 2010) 3 44 58
  2. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N … Larionov V (Genome research 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PMID: 12758128) Zendman AJ … van Muijen GN (Gene 2003) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for SPANXD Gene

Sources for SPANXD Gene

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