SPANXA2 Gene (Protein Coding)

SPANX Family Member A2

GC0XP141590
GIFtS:
26
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes ... See more...

Aliases for SPANXA2 Gene

Aliases for SPANXA2 Gene

  • SPANX Family Member A2 2 3 5
  • Sperm Protein Associated With The Nucleus On The X Chromosome A 3 4
  • Nuclear-Associated Protein SPAN-Xa 3 4
  • Cancer/Testis Antigen 11.1 3 4
  • SPANX Family Member A 3 4
  • SPANX-A 3 4
  • CT11.1 3 4
  • SPANXA 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member A2 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome C 3
  • Cancer/Testis-Associated Protein CTp11 3
  • Nuclear-Associated Protein SPAN-Xc 3
  • Cancer/Testis Antigen 11.3 3
  • SPANX Family, Member A2 2
  • SPANX-C 3
  • SPANXA2 5
  • CT11.3 3
  • SPANXC 3
  • SPAN-X 4
  • SPANX 3

External Ids for SPANXA2 Gene

Previous HGNC Symbols for SPANXA2 Gene

  • SPANX

Previous GeneCards Identifiers for SPANXA2 Gene

  • GC0XU990342
  • GC0XM139366
  • GC0XM139367
  • GC0XM140397
  • GC0XM140500
  • GC0XP140506
  • GC0XP140677

Summaries for SPANXA2 Gene

Entrez Gene Summary for SPANXA2 Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXA2 Gene

SPANXA2 (SPANX Family Member A2) is a Protein Coding gene. An important paralog of this gene is SPANXA1.

Additional gene information for SPANXA2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPANXA2 Gene

Genomics for SPANXA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SPANXA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ141589 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 SPANXA2 SPANXA1 SPANXA2-OT1
GH0XJ141590 Promoter 0.3 EPDnew 600.7 -0.3 -296 0.1 SPANXA2 SPANXA1 SPANXA2-OT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPANXA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPANXA2

Top Transcription factor binding sites by QIAGEN in the SPANXA2 gene promoter:
  • c-Myc
  • Max1

Genomic Locations for SPANXA2 Gene

Genomic Locations for SPANXA2 Gene
chrX:141,589,708-141,590,762
(GRCh38/hg38)
Size:
1,055 bases
Orientation:
Plus strand
chrX:140,677,562-140,678,899
(GRCh37/hg19)
Size:
1,338 bases
Orientation:
Plus strand

Genomic View for SPANXA2 Gene

Genes around SPANXA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXA2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPANXA2 Gene

Proteins for SPANXA2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SPANXA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS26-SPNXA_HUMAN
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome A
    Protein Accession:
    Q9NS26
    Secondary Accessions:
    • Q5JWI0

    Protein attributes for SPANXA2 Gene

    Size:
    97 amino acids
    Molecular mass:
    11038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXA2 Gene

Protein Expression for SPANXA2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SPANXA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXA2 Gene

Domains & Families for SPANXA2 Gene

Gene Families for SPANXA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPANXA2 Gene

GenScript: Design optimal peptide antigens:
  • SPANX-A2 (Q4KRP2_HUMAN)
  • SPANX-A2 (Q4KRP5_HUMAN)
  • SPANX-A2 (Q4KRP8_HUMAN)
  • SPANX family member A (SPNXA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS26

UniProtKB/Swiss-Prot:

SPNXA_HUMAN :
  • Belongs to the SPAN-X family.
Family:
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXA2: view

Function for SPANXA2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for SPANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXA2: view
genes like me logo Genes that share phenotypes with SPANXA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPANXA2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXA2 Gene

Localization for SPANXA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXA2 Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXA2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,HDA 21630459
GO:0005737 cytoplasm TAS,IEA --
genes like me logo Genes that share ontologies with SPANXA2: view

Pathways & Interactions for SPANXA2 Gene

PathCards logo

SuperPathways for SPANXA2 Gene

No Data Available

Interacting Proteins for SPANXA2 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q9NS26-SPNXA_HUMAN ENSP00000359549 for SPANXA2 Gene via UniProtKB STRING IID

GPS-Prot Interaction Network for SPANXA2

Gene Ontology (GO) - Biological Process for SPANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 10906052
genes like me logo Genes that share ontologies with SPANXA2: view

No data available for Pathways by source and SIGNOR curated interactions for SPANXA2 Gene

Drugs & Compounds for SPANXA2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SPANXA2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SPANXA2 Gene

1 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPANXA2

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXA2 Gene

No ASD Table

Relevant External Links for SPANXA2 Gene

GeneLoc Exon Structure for
SPANXA2

Expression for SPANXA2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPANXA2 Gene

mRNA expression in normal human tissues for SPANXA2 Gene
mRNA expression by BioGPS for SPANXA2 GenemRNA expression by GTEx for SPANXA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

Protein differential expression in normal tissues from HIPED for SPANXA2 Gene

This gene is overexpressed in Bone (49.5) and Breast (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPANXA2 Gene



Protein tissue co-expression partners for SPANXA2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPANXA2

SOURCE GeneReport for Unigene cluster for SPANXA2 Gene:

Hs.711784

mRNA Expression by UniProt/SwissProt for SPANXA2 Gene:

Q9NS26-SPNXA_HUMAN
Tissue specificity: Detected in testis and sperm.
genes like me logo Genes that share expression patterns with SPANXA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXA2 Gene

Orthologs for SPANXA2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 57 (a)
 OneToMany
Species where no ortholog for SPANXA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPANXA2 Gene

ENSEMBL:
Gene Tree for SPANXA2 (if available)
TreeFam:
Gene Tree for SPANXA2 (if available)

Paralogs for SPANXA2 Gene

Paralogs for SPANXA2 Gene

(11) SIMAP similar genes for SPANXA2 Gene using alignment to 4 proteins:

  • SPNXA_HUMAN
  • Q4KRP2_HUMAN
  • Q4KRP5_HUMAN
  • Q4KRP8_HUMAN
genes like me logo Genes that share paralogs with SPANXA2: view

Variants for SPANXA2 Gene

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Additional dbSNP identifiers (rs#s) for SPANXA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPANXA2 Gene

Variant ID Type Subtype PubMed ID
dgv2500e212 CNV gain 25503493
dgv2501e212 CNV loss 25503493
dgv2502e212 CNV gain 25503493
esv26320 CNV gain+loss 19812545
esv2752315 CNV gain 17911159
esv2758896 CNV gain+loss 17122850
esv3574870 CNV loss 25503493
esv3574874 CNV loss 25503493
esv3574877 CNV loss 25503493
esv3577446 CNV gain 25503493
nsv469528 CNV loss 16826518
nsv470367 CNV loss 18288195
nsv470369 CNV gain 18288195
nsv471606 CNV gain 15918152
nsv515177 CNV gain 21397061
nsv516880 CNV gain+loss 19592680
nsv7462 OTHER inversion 18451855
nsv9983 CNV gain 18304495

Additional Variant Information for SPANXA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPANXA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SPANXA2 Gene

Disorders for SPANXA2 Gene

Additional Disease Information for SPANXA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPANXA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXA2 Gene

Publications for SPANXA2 Gene

  1. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S … Carrell D (Systems biology in reproductive medicine 2010) 3 41
  2. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N … Larionov V (Genome research 2005) 3 4
  3. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PMID: 12758128) Zendman AJ … van Muijen GN (Gene 2003) 3 4
  4. Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. (PMID: 10906052) Westbrook VA … Herr JC (Biology of reproduction 2000) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

ExternalLinks

View latest publications for SPANXA2 gene in Mastermind

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