This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and deve... See more...

Aliases for SPAG9 Gene

Aliases for SPAG9 Gene

  • Sperm Associated Antigen 9 2 3 5
  • Cancer/Testis Antigen 89 2 3 4
  • Sperm Surface Protein 2 3 4
  • C-Jun NH2-Terminal Kinase-Associated Leucine Zipper Protein 2 3
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 4 3 4
  • C-Jun-Amino-Terminal Kinase-Interacting Protein 4 3 4
  • JNK-Associated Leucine-Zipper Protein 2 4
  • Human Lung Cancer Oncogene 6 Protein 3 4
  • Protein Highly Expressed In Testis 3 4
  • Proliferation-Inducing Gene 6 2 3
  • JNK/SAPK-Associated Protein 2 3
  • JNK Interacting Protein 2 3
  • Lung Cancer Oncogene 4 2 3
  • Max-Binding Protein 2 3
  • Sunday Driver 1 3 4
  • HLC-6 3 4
  • JIP-4 3 4
  • CT89 3 4
  • PHET 3 4
  • JLP 3 4
  • Sperm Associated Antigen 9 Variant 5 3
  • Proliferation-Inducing Protein 6 4
  • Sperm-Associated Antigen 9 4
  • JNK-Interacting Protein 4 4
  • Sperm-Specific Protein 4
  • Sperm Specific Protein 2
  • HLC-4 Protein 2
  • KIAA0516 4
  • MAPK8IP4 4
  • HLC4 3
  • HLC6 3
  • JIP4 3
  • PIG6 3
  • SYD1 4
  • HSS 4

External Ids for SPAG9 Gene

Previous GeneCards Identifiers for SPAG9 Gene

  • GC17M048755
  • GC17M051523
  • GC17M049383
  • GC17M049515
  • GC17M046397
  • GC17M049039
  • GC17M044409

Summaries for SPAG9 Gene

Entrez Gene Summary for SPAG9 Gene

  • This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPAG9 Gene

SPAG9 (Sperm Associated Antigen 9) is a Protein Coding gene. Diseases associated with SPAG9 include Spinocerebellar Ataxia 35 and Infertility. Among its related pathways are Arf6 trafficking events and Akt Signaling. Gene Ontology (GO) annotations related to this gene include kinesin binding and MAP-kinase scaffold activity. An important paralog of this gene is MAPK8IP3.

UniProtKB/Swiss-Prot Summary for SPAG9 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Isoform 5 may play a role in spermatozoa-egg-interaction (PubMed:15693750). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937).

Gene Wiki entry for SPAG9 Gene

Additional gene information for SPAG9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPAG9 Gene

Genomics for SPAG9 Gene

GeneHancer (GH) Regulatory Elements for SPAG9 Gene

Promoters and enhancers for SPAG9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPAG9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPAG9

Top Transcription factor binding sites by QIAGEN in the SPAG9 gene promoter:
  • ATF-2
  • c-Jun
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • XBP-1
  • ZIC2

Genomic Locations for SPAG9 Gene

Genomic Locations for SPAG9 Gene
chr17:50,962,174-51,120,868
(GRCh38/hg38)
Size:
158,695 bases
Orientation:
Minus strand
chr17:49,039,535-49,198,226
(GRCh37/hg19)
Size:
158,692 bases
Orientation:
Minus strand

Genomic View for SPAG9 Gene

Genes around SPAG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG9 Gene

Proteins for SPAG9 Gene

  • Protein details for SPAG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60271-JIP4_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 4
    Protein Accession:
    O60271
    Secondary Accessions:
    • A6H8U5
    • A8MSX0
    • B4DHH2
    • O60905
    • Q3KQU8
    • Q3MKM7
    • Q86WC7
    • Q86WC8
    • Q8IZX7
    • Q96II0
    • Q9H811

    Protein attributes for SPAG9 Gene

    Size:
    1321 amino acids
    Molecular mass:
    146205 Da
    Quaternary structure:
    • Homodimer (PubMed:19644450). The homodimer interacts with ARF6, forming a heterotetramer (PubMed:19644450). Homooligomer (PubMed:19644450). Interacts with MAX, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4 (By similarity). Interaction with KNS2 is important in the formation of ternary complex with MAPK8 (By similarity). Interacts with NFKB1 (PubMed:14743216). Isoform 5 interacts with MAPK8, MAPK9, MAPK10 (PubMed:15693750). Interacts with PIP4P1 (PubMed:29146937).
    Miscellaneous:
    • [Isoform 3]: Due to intron retention.
    SequenceCaution:
    • Sequence=AAH07524.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH59946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI06049.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAO66462.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA25442.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14812.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAA62987.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPAG9 Gene

    Alternative splice isoforms for SPAG9 Gene

neXtProt entry for SPAG9 Gene

Post-translational modifications for SPAG9 Gene

  • Phosphorylated by MAPK8 and MAPK14.
  • Ubiquitination at Lys233, Lys653, and Lys1227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPAG9 Gene

Domains & Families for SPAG9 Gene

Gene Families for SPAG9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SPAG9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61493, highly similar to C-jun-amino-terminal kinase-interacting protein 4 (A6H8U5_HUMAN)
  • Sunday driver 1 (JIP4_HUMAN)
  • cDNA FLJ13450 fis, clone PLACE1003027, highly similar to C-jun-amino-terminal kinase-interacting protein 4 (Q7Z5Q8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60271

UniProtKB/Swiss-Prot:

JIP4_HUMAN :
  • Belongs to the JIP scaffold family.
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with SPAG9: view

Function for SPAG9 Gene

Molecular function for SPAG9 Gene

UniProtKB/Swiss-Prot Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Isoform 5 may play a role in spermatozoa-egg-interaction (PubMed:15693750). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937).
UniProtKB/Swiss-Prot Induction:
Isoform 3 is increased in systemic sclerosis fibroblasts.

Phenotypes From GWAS Catalog for SPAG9 Gene

Gene Ontology (GO) - Molecular Function for SPAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005078 MAP-kinase scaffold activity IEA,IBA 21873635
GO:0005515 protein binding IEA,IPI 19644450
GO:0008432 JUN kinase binding IBA 21873635
GO:0019894 kinesin binding IBA 21873635
GO:0030159 receptor signaling complex scaffold activity IBA 21873635
genes like me logo Genes that share ontologies with SPAG9: view
genes like me logo Genes that share phenotypes with SPAG9: view

Animal Models for SPAG9 Gene

MGI Knock Outs for SPAG9:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPAG9 Gene

Localization for SPAG9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG9 Gene

Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000250 UniProtKB:Q58A65}.
[Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. {ECO:0000269 PubMed:15693750}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPAG9 gene
Compartment Confidence
cytosol 5
lysosome 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (4)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA,IEA 29146937
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with SPAG9: view

Pathways & Interactions for SPAG9 Gene

genes like me logo Genes that share pathways with SPAG9: view

Pathways by source for SPAG9 Gene

1 BioSystems pathway for SPAG9 Gene
3 Reactome pathways for SPAG9 Gene
1 Qiagen pathway for SPAG9 Gene
  • p38 Signaling
1 Cell Signaling Technology pathway for SPAG9 Gene

SIGNOR curated interactions for SPAG9 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SPAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007257 activation of JUN kinase activity IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0030335 positive regulation of cell migration IMP 18826971
GO:0032418 lysosome localization IMP 29146937
GO:0042147 retrograde transport, endosome to Golgi IDA 19056739
genes like me logo Genes that share ontologies with SPAG9: view

Drugs & Compounds for SPAG9 Gene

(5) Drugs for SPAG9 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea Experimental Pharma Target 0

(2) Additional Compounds for SPAG9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPAG9: view

Transcripts for SPAG9 Gene

mRNA/cDNA for SPAG9 Gene

5 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 32c · 32d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SPAG9 Gene

GeneLoc Exon Structure for
SPAG9

Expression for SPAG9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPAG9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPAG9 Gene

This gene is overexpressed in Heart (30.6), Peripheral blood mononuclear cells (6.5), and Bone marrow stromal cell (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPAG9 Gene



Protein tissue co-expression partners for SPAG9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPAG9

SOURCE GeneReport for Unigene cluster for SPAG9 Gene:

Hs.463439

mRNA Expression by UniProt/SwissProt for SPAG9 Gene:

O60271-JIP4_HUMAN
Tissue specificity: Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.

Evidence on tissue expression from TISSUES for SPAG9 Gene

  • Nervous system(5)
  • Kidney(4.4)
  • Eye(4.3)
  • Liver(4.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with SPAG9: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPAG9 Gene

Orthologs for SPAG9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPAG9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPAG9 31 30
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPAG9 31 30
  • 94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SPAG9 31 30
  • 92.48 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPAG9 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spag9 17 31 30
  • 90.67 (n)
rat
(Rattus norvegicus)
Mammalia Spag9 30
  • 89.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPAG9 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPAG9 31 30
  • 82.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPAG9 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spag9 30
  • 67.98 (n)
Str.1719 30
zebrafish
(Danio rerio)
Actinopterygii LOC100333761 30
  • 65.76 (n)
CABZ01073118.1 31
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005042 30
  • 52.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta syd 30
  • 52.03 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-16 30
  • 53.91 (n)
Species where no ortholog for SPAG9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPAG9 Gene

ENSEMBL:
Gene Tree for SPAG9 (if available)
TreeFam:
Gene Tree for SPAG9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPAG9: view image

Paralogs for SPAG9 Gene

Paralogs for SPAG9 Gene

(2) SIMAP similar genes for SPAG9 Gene using alignment to 5 proteins:

  • JIP4_HUMAN
  • D6RHI8_HUMAN
  • H0Y981_HUMAN
  • H0YBE9_HUMAN
  • H0YBS5_HUMAN
genes like me logo Genes that share paralogs with SPAG9: view

Variants for SPAG9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPAG9 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
689672 Uncertain Significance: Marfanoid habitus and intellectual disability 51,041,592(-) G/A MISSENSE_VARIANT
717062 Benign: not provided 50,982,647(-) A/G SYNONYMOUS_VARIANT
717063 Benign: not provided 50,993,785(-) G/A SYNONYMOUS_VARIANT
722228 Benign: not provided 50,984,913(-) C/T INTRON_VARIANT
747599 Likely Benign: not provided 50,989,671(-) T/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SPAG9 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPAG9 Gene

Variant ID Type Subtype PubMed ID
dgv1481n106 CNV tandem duplication 24896259
esv2178597 CNV deletion 18987734
esv2667230 CNV deletion 23128226
esv2672135 CNV deletion 23128226
esv2716042 CNV deletion 23290073
esv3554537 CNV deletion 23714750
esv3640760 CNV loss 21293372
nsv1055743 CNV loss 25217958
nsv1131329 CNV deletion 24896259
nsv457825 CNV gain 19166990
nsv525470 CNV loss 19592680
nsv575524 CNV gain 21841781
nsv833480 CNV loss 17160897

Variation tolerance for SPAG9 Gene

Residual Variation Intolerance Score: 6.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPAG9 Gene

Human Gene Mutation Database (HGMD)
SPAG9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPAG9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG9 Gene

Disorders for SPAG9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SPAG9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 35
  • sca35
infertility
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search SPAG9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPAG9

genes like me logo Genes that share disorders with SPAG9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPAG9 Gene

Publications for SPAG9 Gene

  1. Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. (PMID: 9480848) Shankar S … Suri A (Biochemical and biophysical research communications 1998) 2 3 4 23 54
  2. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PMID: 15693750) Jagadish N … Suri A (The Biochemical journal 2005) 3 4 23 54
  3. A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. (PMID: 14662895) Yasuoka H … Kuwana M (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 4 23 54
  4. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. (PMID: 12391307) Lee CM … Reddy EP (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 23 54
  5. TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes. (PMID: 29146937) Willett R … Puertollano R (Nature communications 2017) 3 4 54

Products for SPAG9 Gene