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Aliases for SPAG11B Gene

Aliases for SPAG11B Gene

  • Sperm Associated Antigen 11B 2 3 5
  • Human Epididymis-Specific Protein 2 3 4
  • Epididymal Protein 2B 2 3
  • Sperm Antigen HE2 3 4
  • EP2 3 4
  • HE2 3 4
  • Sperm-Associated Antigen 11B 3
  • Protein EP2 4
  • EDDM2B 3
  • SPAG11 3
  • EP2C 3
  • EP2D 3
  • HE2C 3

External Ids for SPAG11B Gene

Previous GeneCards Identifiers for SPAG11B Gene

  • GC08M007294

Summaries for SPAG11B Gene

Entrez Gene Summary for SPAG11B Gene

  • This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPAG11B Gene

SPAG11B (Sperm Associated Antigen 11B) is a Protein Coding gene. An important paralog of this gene is SPAG11A.

Gene Wiki entry for SPAG11B Gene

Additional gene information for SPAG11B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG11B Gene

Genomics for SPAG11B Gene

GeneHancer (GH) Regulatory Elements for SPAG11B Gene

Promoters and enhancers for SPAG11B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I007463 Promoter 0.5 EPDnew 550.8 +0.1 112 0.1 SPAG11B DEFB103B
GH08I007447 Enhancer 0.2 Ensembl 0.4 +15.8 15834 1.3 SPAG11B DEFB103B
GH08I007434 Enhancer 0.2 dbSUPER 0.3 +27.3 27299 4.7 DEFB103B SPAG11B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPAG11B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPAG11B gene promoter:

Genomic Locations for SPAG11B Gene

Genomic Locations for SPAG11B Gene
20,991 bases
Minus strand

Genomic View for SPAG11B Gene

Genes around SPAG11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAG11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAG11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG11B Gene

Proteins for SPAG11B Gene

  • Protein details for SPAG11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm-associated antigen 11B
    Protein Accession:
    Secondary Accessions:
    • E9PFH0
    • Q546A0
    • Q6ZYB2
    • Q9H4P8
    • Q9H4P9
    • Q9H4Q0
    • Q9H4Q1
    • Q9H4Q2
    • Q9NRT3
    • Q9NRV4
    • Q9NRV5
    • Q9NRV6
    • Q9NRV7
    • Q9NRV8

    Protein attributes for SPAG11B Gene

    103 amino acids
    Molecular mass:
    11431 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPAG11B Gene

neXtProt entry for SPAG11B Gene

Post-translational modifications for SPAG11B Gene

No data available for DME Specific Peptides for SPAG11B Gene

Domains & Families for SPAG11B Gene

Gene Families for SPAG11B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPAG11B Gene


Suggested Antigen Peptide Sequences for SPAG11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAG11 family.
  • Belongs to the SPAG11 family.
genes like me logo Genes that share domains with SPAG11B: view

Function for SPAG11B Gene

Gene Ontology (GO) - Molecular Function for SPAG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPAG11B: view

Phenotypes for SPAG11B Gene

GenomeRNAi human phenotypes for SPAG11B:
genes like me logo Genes that share phenotypes with SPAG11B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPAG11B Gene

Localization for SPAG11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG11B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPAG11B gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for SPAG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 10698202
genes like me logo Genes that share ontologies with SPAG11B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPAG11B Gene

Pathways & Interactions for SPAG11B Gene

SuperPathways for SPAG11B Gene

No Data Available

Interacting Proteins for SPAG11B Gene

Selected Interacting proteins: Q08648-SG11B_HUMAN for SPAG11B Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPAG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 8167223
genes like me logo Genes that share ontologies with SPAG11B: view

No data available for Pathways by source and SIGNOR curated interactions for SPAG11B Gene

Drugs & Compounds for SPAG11B Gene

(1) Additional Compounds for SPAG11B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPAG11B: view

Transcripts for SPAG11B Gene

Unigene Clusters for SPAG11B Gene

Sperm associated antigen 11B:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG11B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: - - - -
SP5: - - -

Relevant External Links for SPAG11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPAG11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPAG11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SPAG11B Gene:


SOURCE GeneReport for Unigene cluster for SPAG11B Gene:


mRNA Expression by UniProt/SwissProt for SPAG11B Gene:

Tissue specificity: Specifically expressed in caput and proximal corpus of epididymis. Present in the epididymal epithelium and on the sperm surface, with a subacrosomal equatorial distribution on the sperm head.
genes like me logo Genes that share expression patterns with SPAG11B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPAG11B Gene

Orthologs for SPAG11B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPAG11B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPAG11B 33
  • 99.41 (n)
SPAG11 34
  • 98 (a)
(Canis familiaris)
Mammalia SPAG11B 33
  • 76.28 (n)
SPAG11 34
  • 41 (a)
(Mus musculus)
Mammalia Spag11b 33 16 34
  • 71.77 (n)
(Rattus norvegicus)
Mammalia LOC100362580 33
  • 71.17 (n)
(Bos Taurus)
Mammalia SPAG11 34
  • 32 (a)
Species where no ortholog for SPAG11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPAG11B Gene

Gene Tree for SPAG11B (if available)
Gene Tree for SPAG11B (if available)

Paralogs for SPAG11B Gene

Paralogs for SPAG11B Gene

genes like me logo Genes that share paralogs with SPAG11B: view

Variants for SPAG11B Gene

Sequence variations from dbSNP and Humsavar for SPAG11B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000646281 -- 7,449,544(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000909932 -- 7,447,805(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1005162578 -- 7,451,660(-) G/A genic_downstream_transcript_variant, intron_variant
rs1005541408 -- 7,454,425(-) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1007931434 -- 7,447,739(-) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPAG11B Gene

Variant ID Type Subtype PubMed ID
dgv6949n100 CNV gain 25217958
dgv6948n100 CNV gain+loss 25217958
dgv6943n100 CNV gain 25217958
dgv6942n100 CNV loss 25217958
dgv6941n100 CNV gain+loss 25217958
dgv6940n100 CNV loss 25217958
dgv6939n100 CNV gain 25217958
dgv6938n100 CNV loss 25217958
dgv6937n100 CNV loss 25217958
dgv6936n100 CNV gain+loss 25217958
dgv6935n100 CNV gain 25217958
dgv6934n100 CNV gain+loss 25217958
dgv6933n100 CNV loss 25217958
dgv6932n100 CNV gain+loss 25217958
dgv6931n100 CNV gain+loss 25217958
dgv6930n100 CNV gain+loss 25217958
dgv6929n100 CNV loss 25217958
dgv6928n100 CNV gain 25217958
dgv6927n100 CNV gain+loss 25217958
dgv6926n100 CNV loss 25217958
dgv6925n100 CNV gain 25217958
dgv6924n100 CNV loss 25217958
dgv6923n100 CNV gain+loss 25217958
dgv6922n100 CNV gain+loss 25217958
dgv6921n100 CNV loss 25217958
dgv6920n100 CNV gain 25217958
dgv6915n100 CNV gain 25217958
dgv6912n100 CNV loss 25217958
dgv6911n100 CNV loss 25217958
dgv6910n100 CNV gain+loss 25217958
dgv6909n100 CNV gain 25217958
dgv6908n100 CNV gain 25217958
dgv6907n100 CNV loss 25217958
dgv6906n100 CNV gain 25217958
dgv6905n100 CNV gain 25217958
dgv6898n100 CNV loss 25217958
dgv6896n100 CNV gain+loss 25217958
dgv6895n100 CNV loss 25217958
dgv6894n100 CNV gain+loss 25217958
dgv6893n100 CNV gain 25217958
dgv6890n100 CNV gain 25217958
dgv6887n100 CNV loss 25217958
dgv6885n100 CNV gain 25217958
dgv6882n100 CNV gain 25217958
dgv31n14 CNV loss 18776910
dgv26n31 CNV gain 19718026
dgv25n31 CNV gain 19718026
dgv2035e212 CNV gain 25503493
dgv11935n54 CNV gain 21841781
dgv11934n54 CNV loss 21841781
dgv11933n54 CNV loss 21841781
dgv11932n54 CNV loss 21841781
dgv11931n54 CNV loss 21841781
dgv11930n54 CNV gain 21841781
dgv11929n54 CNV loss 21841781
dgv11928n54 CNV gain 21841781
dgv11920n54 CNV loss 21841781
dgv11919n54 CNV loss 21841781
dgv11918n54 CNV loss 21841781
dgv11917n54 CNV gain 21841781
dgv11916n54 CNV loss 21841781
dgv11915n54 CNV loss 21841781
dgv11914n54 CNV gain 21841781
dgv11913n54 CNV gain 21841781
dgv11912n54 CNV loss 21841781
dgv11911n54 CNV loss 21841781
dgv1170n67 CNV loss 20364138
nsv610077 CNV gain 21841781
nsv610065 CNV gain+loss 21841781
nsv610044 CNV gain 21841781
nsv515968 CNV gain+loss 19592680
nsv515100 CNV gain 21397061
nsv510977 OTHER complex 20534489
nsv508496 CNV deletion 20534489
nsv482120 CNV gain 20164927
nsv471650 CNV gain+loss 15918152
nsv471458 CNV gain 19718026
nsv469521 CNV gain+loss 16826518
nsv442397 CNV gain 18776908
nsv433398 CNV gain 18776910
nsv428194 CNV gain+loss 18775914
nsv1141572 CNV duplication 24896259
nsv1139926 CNV duplication 24896259
nsv1078040 CNV duplication 25765185
nsv1076641 CNV duplication 25765185
nsv1032072 CNV gain 25217958
nsv1031577 CNV gain 25217958
nsv1031322 CNV loss 25217958
nsv1030619 CNV loss 25217958
nsv1029830 CNV gain 25217958
nsv1028208 CNV loss 25217958
nsv1027709 CNV gain+loss 25217958
nsv1027507 CNV loss 25217958
nsv1026778 CNV gain 25217958
nsv1017081 CNV gain 25217958
nsv1015218 CNV gain 25217958
esv996398 CNV gain 20482838
esv992071 CNV gain 20482838
esv3891325 CNV gain 25118596
esv3891324 CNV gain 25118596
esv3891323 CNV gain+loss 25118596
esv3891321 CNV gain+loss 25118596
esv3891318 CNV gain 25118596
esv3616114 CNV loss 21293372
esv3584577 CNV gain 24956385
esv3584575 CNV gain 24956385
esv3584574 CNV gain 24956385
esv33606 CNV gain+loss 17666407
esv2764098 CNV gain+loss 21179565
esv2761169 CNV gain+loss 21179565
esv2759589 CNV gain+loss 17122850
esv2752266 CNV loss 17911159
esv2752265 CNV gain 17911159
esv25631 CNV gain+loss 19812545
esv21583 CNV gain+loss 19812545
dgv6966n100 CNV loss 25217958
dgv6965n100 CNV gain+loss 25217958
dgv6964n100 CNV gain 25217958
dgv6963n100 CNV loss 25217958
dgv6962n100 CNV gain 25217958
dgv6961n100 CNV gain+loss 25217958
dgv6960n100 CNV loss 25217958
dgv6959n100 CNV loss 25217958
dgv6958n100 CNV gain+loss 25217958
dgv6955n100 CNV gain 25217958
dgv6950n100 CNV loss 25217958
nsv967558 CNV duplication 23825009
nsv967555 CNV duplication 23825009
nsv951093 CNV deletion 24416366
nsv951092 CNV deletion 24416366
nsv8281 CNV gain+loss 18304495
nsv824524 CNV gain+loss 20364138
nsv824521 CNV gain 20364138
nsv824519 CNV loss 20364138
nsv821656 CNV gain 15273396
nsv610129 CNV loss 21841781
nsv610119 CNV gain+loss 21841781
nsv610116 CNV loss 21841781
nsv610113 CNV loss 21841781
nsv610102 CNV gain+loss 21841781

Variation tolerance for SPAG11B Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPAG11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG11B Gene

Disorders for SPAG11B Gene

Additional Disease Information for SPAG11B

No disorders were found for SPAG11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPAG11B Gene

Publications for SPAG11B Gene

  1. Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis. (PMID: 8167223) Osterhoff C … Ivell R (Biology of reproduction 1994) 2 3 4 22 58
  2. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. (PMID: 11259252) Fröhlich O … Young LG (Biology of reproduction 2001) 3 4 22 58
  3. HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human. (PMID: 10698202) Hamil KG … Hall SH (Endocrinology 2000) 3 4 22 58
  4. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y … French FS (Biology of reproduction 2009) 3 22 58
  5. Antimicrobial actions of human and macaque sperm associated antigen (SPAG) 11 isoforms: influence of the N-terminal peptide. (PMID: 16411022) Yenugu S … Hall SH (Molecular and cellular biochemistry 2006) 3 22 58

Products for SPAG11B Gene

Sources for SPAG11B Gene

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