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Aliases for SPACA9 Gene

Aliases for SPACA9 Gene

  • Sperm Acrosome Associated 9 2 3 5
  • C9orf9 3 4
  • Sperm Acrosome-Associated Protein 9 3
  • Chromosome 9 Open Reading Frame 9 2
  • Uncharacterized Protein C9orf9 3
  • Rsb66 Homolog 3
  • Mast 3

External Ids for SPACA9 Gene

Previous HGNC Symbols for SPACA9 Gene

  • C9orf9

Summaries for SPACA9 Gene

GeneCards Summary for SPACA9 Gene

SPACA9 (Sperm Acrosome Associated 9) is a Protein Coding gene.

Additional gene information for SPACA9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA9 Gene

Genomics for SPACA9 Gene

GeneHancer (GH) Regulatory Elements for SPACA9 Gene

Promoters and enhancers for SPACA9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I132877 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1148 3.2 CLOCK ARID4B SIN3A ZNF207 ZNF143 KLF13 SP3 SP5 ZHX2 MXD4 AK8 SPACA9 PIR61136
GH09I133029 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22 +152.7 152680 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTF3C5 LOC105376306 SETX TTF1 MED22 DDX31 TSC1 GTF3C4 BRD3OS SPACA9
GH09I132901 Enhancer 1 ENCODE dbSUPER 11.9 +23.8 23839 0.8 ATF1 ARNT ARID4B ZNF2 RAD21 RFX5 ZNF143 ATF7 RCOR1 CREM AK8 SPACA9 TSC1 PIR193201 PIR60978
GH09I132780 Enhancer 1 Ensembl ENCODE 10.8 -97.2 -97205 1.2 HDAC1 ATF1 ARNT NFRKB EGR1 FOS CREM JUNB ELF1 ZNF148 AK8 SPACA9 RNU5D-2P TTF1 PIR47443
GH09I132744 Enhancer 0.8 UCNEbase 10.6 -133.2 -133196 0.3 SP2 OSR2 PRDM6 ZSCAN16 GLIS1 PATZ1 ZNF341 CTBP2 ZNF600 WT1 AK8 SPACA9 RNU7-21P RPL39P24 ENSG00000224992 GC09M132712
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPACA9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPACA9 Gene

Genomic Locations for SPACA9 Gene
chr9:132,878,027-132,890,201
(GRCh38/hg38)
Size:
12,175 bases
Orientation:
Plus strand
chr9:135,753,414-135,765,588
(GRCh37/hg19)

Genomic View for SPACA9 Gene

Genes around SPACA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA9 Gene

Proteins for SPACA9 Gene

  • Protein details for SPACA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E40-SACA9_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 9
    Protein Accession:
    Q96E40
    Secondary Accessions:
    • Q9UGQ0

    Protein attributes for SPACA9 Gene

    Size:
    222 amino acids
    Molecular mass:
    25166 Da
    Quaternary structure:
    • Interacts with CABP1 AND CALR.

    Alternative splice isoforms for SPACA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA9 Gene

Post-translational modifications for SPACA9 Gene

No Post-translational modifications

Other Protein References for SPACA9 Gene

No data available for DME Specific Peptides for SPACA9 Gene

Domains & Families for SPACA9 Gene

Gene Families for SPACA9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPACA9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA9: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPACA9 Gene

Function for SPACA9 Gene

Gene Ontology (GO) - Molecular Function for SPACA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0048306 calcium-dependent protein binding IEA --
genes like me logo Genes that share ontologies with SPACA9: view
genes like me logo Genes that share phenotypes with SPACA9: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA9 Gene

Localization for SPACA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA9 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. {ECO:0000250 UniProtKB:Q7TPM5}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA9 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 3
nucleus 2
cytosol 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPACA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IEA --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SPACA9: view

Pathways & Interactions for SPACA9 Gene

SuperPathways for SPACA9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPACA9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPACA9 Gene

Drugs & Compounds for SPACA9 Gene

No Compound Related Data Available

Transcripts for SPACA9 Gene

mRNA/cDNA for SPACA9 Gene

(5) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA9 Gene

No ASD Table

Relevant External Links for SPACA9 Gene

GeneLoc Exon Structure for
SPACA9
ECgene alternative splicing isoforms for
SPACA9

Expression for SPACA9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA9 Gene:

SPACA9

Evidence on tissue expression from TISSUES for SPACA9 Gene

  • Thyroid gland(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA9 Gene

Orthologs for SPACA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPACA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9orf9 34
  • 99 (a)
OneToOne
C9H9orf9 33
  • 97.36 (n)
dog
(Canis familiaris)
Mammalia C9H9orf9 33
  • 89.48 (n)
C9ORF9 34
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsb66 33
  • 88.49 (n)
cow
(Bos Taurus)
Mammalia C11H9orf9 33
  • 88.41 (n)
C11H9ORF9 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700026L06Rik 34 33
  • 86.9 (n)
OneToOne
Spaca9 16
oppossum
(Monodelphis domestica)
Mammalia C9orf9 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf9 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9ORF9 34 33
  • 69.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf9 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf9 33
  • 63.69 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153740 33
  • 55.63 (n)
C5H9orf9 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10159 34
  • 17 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
Species where no ortholog for SPACA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPACA9 Gene

ENSEMBL:
Gene Tree for SPACA9 (if available)
TreeFam:
Gene Tree for SPACA9 (if available)

Paralogs for SPACA9 Gene

No data available for Paralogs for SPACA9 Gene

Variants for SPACA9 Gene

Sequence variations from dbSNP and Humsavar for SPACA9 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000177188 -- 132,884,932(+) G/A intron_variant
rs1000229577 -- 132,884,719(+) T/TT intron_variant
rs1000304673 -- 132,878,335(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000440912 -- 132,889,576(+) A/G/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000601599 -- 132,884,534(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA9 Gene

Variant ID Type Subtype PubMed ID
nsv831743 CNV loss 17160897
esv3621927 CNV gain 21293372
esv3621926 CNV loss 21293372
esv3621925 CNV loss 21293372
esv3545558 CNV deletion 23714750
esv3397210 CNV duplication 20981092
esv2739146 CNV deletion 23290073
esv2739138 CNV deletion 23290073
esv2671227 CNV deletion 23128226

Variation tolerance for SPACA9 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPACA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA9 Gene

Disorders for SPACA9 Gene

No disorders were found for SPACA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA9 Gene

Publications for SPACA9 Gene

  1. A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome. (PMID: 24256100) Bhattacharya R … Jesudasan RA (BMC cell biology 2013) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SPACA9 Gene

Sources for SPACA9 Gene

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