Aliases for SPACA6 Gene

Aliases for SPACA6 Gene

  • Sperm Acrosome Associated 6 2 3 5
  • Sperm Acrosome Membrane-Associated Protein 6 3 4
  • Long Intergenic Non-Protein Coding RNA 85 2 3
  • Sperm Acrosome Associated 6, Pseudogene 2 3
  • BACHELOR-Like Protein 3 4
  • Let-7e Host 2 3
  • SPACA6P 3 4
  • LET7EH 2 3
  • Non-Protein Coding RNA 85 2
  • NCRNA00085 3
  • LINC00085 3
  • SPACA6 5

External Ids for SPACA6 Gene

Previous HGNC Symbols for SPACA6 Gene

  • NCRNA00085
  • LINC00085
  • SPACA6P

Previous GeneCards Identifiers for SPACA6 Gene

  • GC19P051691
  • GC19P051727
  • GC19P051721
  • GC19P051717
  • GC19P051703
  • GC19P051706
  • GC19P051710
  • GC19P051713

Summaries for SPACA6 Gene

GeneCards Summary for SPACA6 Gene

SPACA6 (Sperm Acrosome Associated 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SPACA6 Gene

  • Sperm protein required for fusion of sperm with the egg membrane during fertilization.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPACA6 Gene

Genomics for SPACA6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPACA6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPACA6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPACA6

Genomic Locations for SPACA6 Gene

Latest Assembly
chr19:51,685,595-51,713,157
(GRCh38/hg38)
Size:
27,563 bases
Orientation:
Plus strand

Previous Assembly
chr19:52,192,635-52,208,443
(GRCh37/hg19 by Entrez Gene)
Size:
15,809 bases
Orientation:
Plus strand

chr19:52,196,593-52,215,640
(GRCh37/hg19 by Ensembl)
Size:
19,048 bases
Orientation:
Plus strand

Genomic View for SPACA6 Gene

Genes around SPACA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA6 Gene

Proteins for SPACA6 Gene

  • Protein details for SPACA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    W5XKT8-SACA6_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 6
    Protein Accession:
    W5XKT8
    Secondary Accessions:
    • C0H5Y6
    • Q6UWG3

    Protein attributes for SPACA6 Gene

    Size:
    324 amino acids
    Molecular mass:
    36333 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: Due to intron retention.
    • [Isoform 3]: Due to intron retention.

    Alternative splice isoforms for SPACA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA6 Gene

Post-translational modifications for SPACA6 Gene

  • Glycosylation at Asn243
  • Modification sites at PhosphoSitePlus

Other Protein References for SPACA6 Gene

No data available for DME Specific Peptides for SPACA6 Gene

Domains & Families for SPACA6 Gene

Gene Families for SPACA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPACA6 Gene

Graphical View of Domain Structure for InterPro Entry

W5XKT8

UniProtKB/Swiss-Prot:

SACA6_HUMAN :
  • Belongs to the SPACA6 family.
Family:
  • Belongs to the SPACA6 family.
genes like me logo Genes that share domains with SPACA6: view

No data available for Suggested Antigen Peptide Sequences for SPACA6 Gene

Function for SPACA6 Gene

Molecular function for SPACA6 Gene

UniProtKB/Swiss-Prot Function:
Sperm protein required for fusion of sperm with the egg membrane during fertilization.

Phenotypes From GWAS Catalog for SPACA6 Gene

Gene Ontology (GO) - Molecular Function for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPACA6: view

Phenotypes for SPACA6 Gene

genes like me logo Genes that share phenotypes with SPACA6: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA6 Gene

Localization for SPACA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA6 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane. Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SPACA6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SPACA6 Gene

Pathways & Interactions for SPACA6 Gene

PathCards logo

SuperPathways for SPACA6 Gene

No Data Available

Interacting Proteins for SPACA6 Gene

Selected Interacting proteins: W5XKT8-SACA6_HUMAN for SPACA6 Gene via UniProtKB IID

Symbol External ID(s) Details
BANP

Gene Ontology (GO) - Biological Process for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IBA,ISS --
genes like me logo Genes that share ontologies with SPACA6: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA6 Gene

Drugs & Compounds for SPACA6 Gene

No Compound Related Data Available

Transcripts for SPACA6 Gene

mRNA/cDNA for SPACA6 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA6

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA6 Gene

No ASD Table

Relevant External Links for SPACA6 Gene

GeneLoc Exon Structure for
SPACA6

Expression for SPACA6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPACA6

mRNA Expression by UniProt/SwissProt for SPACA6 Gene:

W5XKT8-SACA6_HUMAN
Tissue specificity: Detected at the sperm head, equatorial region, neck and midpiece (at protein level) (PubMed:32210282). Expressed in testis (PubMed:24275887).

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA6 Gene

Orthologs for SPACA6 Gene

Evolution for SPACA6 Gene

ENSEMBL:
Gene Tree for SPACA6 (if available)
TreeFam:
Gene Tree for SPACA6 (if available)

No data available for Orthologs for SPACA6 Gene

Paralogs for SPACA6 Gene

No data available for Paralogs for SPACA6 Gene

Variants for SPACA6 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPACA6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPACA6 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3644679 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Additional Variant Information for SPACA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SPACA6 Gene

Disorders for SPACA6 Gene

Additional Disease Information for SPACA6

No disorders were found for SPACA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA6 Gene

Publications for SPACA6 Gene

  1. A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion. (PMID: 24275887) Lorenzetti D … Bishop CE (Mammalian genome : official journal of the International Mammalian Genome Society 2014) 2 3 4
  2. Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion. (PMID: 32210282) Barbaux S … Ziyyat A (Scientific reports 2020) 3 4
  3. Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes. (PMID: 23044541) Gascoigne DK … Mattick JS (Bioinformatics (Oxford, England) 2012) 2 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for SPACA6 Gene

Sources for SPACA6 Gene