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Aliases for SPACA6 Gene

Aliases for SPACA6 Gene

  • Sperm Acrosome Associated 6 2 2 3 5
  • Long Intergenic Non-Protein Coding RNA 85 2 3
  • Sperm Acrosome Associated 6, Pseudogene 2 3
  • BACHELOR-Like Protein 3 4
  • Let-7e Host 2 3
  • SPACA6P 3 4
  • Sperm Acrosome Membrane-Associated Protein 6 3
  • Non-Protein Coding RNA 85 2
  • NCRNA00085 3
  • LINC00085 3
  • LET7EH 3

External Ids for SPACA6 Gene

Previous HGNC Symbols for SPACA6 Gene

  • NCRNA00085
  • LINC00085
  • SPACA6P

Previous GeneCards Identifiers for SPACA6 Gene

  • GC19P051703
  • GC19P051706
  • GC19P051710
  • GC19P051713
  • GC19P051717

Summaries for SPACA6 Gene

GeneCards Summary for SPACA6 Gene

SPACA6 (Sperm Acrosome Associated 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA6 Gene

  • Sperm protein potentially involved sperm-egg fusion.

Additional gene information for SPACA6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA6 Gene

Genomics for SPACA6 Gene

GeneHancer (GH) Regulatory Elements for SPACA6 Gene

Promoters and enhancers for SPACA6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21 -2.8 -2849 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 21.7 -298.3 -298293 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ENSG00000268889 LOC105372446 ZNF841 ZNF766 ZNF577 ZNF616 ZNF175 ZNF836 ZNF432 ZNF614
GH19I050802 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.5 -889.1 -889057 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 C19orf48 GC19M050838 SNORD88C GC19M050829 POLD1 PTOV1-AS2 NUP62 PNKP ZNF175 CTU1
GH19I051545 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -143.6 -143567 8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A IRF4 POLR2B SIGLEC6 ZNF175 ZNF841 ZNF616 ZNF836 ZNF808 SIGLEC14 SIGLEC8 ZNF350 CEACAM18
GH19I051016 Enhancer 1.1 Ensembl ENCODE 13.5 -676.0 -675963 1.5 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 KLF13 SP3 ZNF175 ZNF615 KLK10 ZNF577 LRRC4B POLD1 SPACA6 ZNF613 ZNF350 KLK13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPACA6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPACA6 Gene

Genomic Locations for SPACA6 Gene
chr19:51,693,340-51,712,387
(GRCh38/hg38)
Size:
19,048 bases
Orientation:
Plus strand
chr19:52,196,593-52,215,640
(GRCh37/hg19)

Genomic View for SPACA6 Gene

Genes around SPACA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA6 Gene

Proteins for SPACA6 Gene

  • Protein details for SPACA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    W5XKT8-SACA6_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 6
    Protein Accession:
    W5XKT8
    Secondary Accessions:
    • C0H5Y6
    • Q6UWG3

    Protein attributes for SPACA6 Gene

    Size:
    324 amino acids
    Molecular mass:
    36333 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPACA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA6 Gene

Post-translational modifications for SPACA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA6 Gene

No data available for DME Specific Peptides for SPACA6 Gene

Domains & Families for SPACA6 Gene

Gene Families for SPACA6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPACA6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA6: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPACA6 Gene

Function for SPACA6 Gene

Molecular function for SPACA6 Gene

UniProtKB/Swiss-Prot Function:
Sperm protein potentially involved sperm-egg fusion.

Phenotypes From GWAS Catalog for SPACA6 Gene

Gene Ontology (GO) - Molecular Function for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPACA6: view

Phenotypes for SPACA6 Gene

GenomeRNAi human phenotypes for SPACA6:
genes like me logo Genes that share phenotypes with SPACA6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA6 Gene

Localization for SPACA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA6 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SPACA6 Gene

Pathways & Interactions for SPACA6 Gene

SuperPathways for SPACA6 Gene

No Data Available

Interacting Proteins for SPACA6 Gene

Selected Interacting proteins: W5XKT8-SACA6_HUMAN for SPACA6 Gene via UniProtKB

Symbol External ID(s) Details
BANP

Gene Ontology (GO) - Biological Process for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IEA --
genes like me logo Genes that share ontologies with SPACA6: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA6 Gene

Drugs & Compounds for SPACA6 Gene

No Compound Related Data Available

Transcripts for SPACA6 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA6 Gene

No ASD Table

Relevant External Links for SPACA6 Gene

GeneLoc Exon Structure for
SPACA6
ECgene alternative splicing isoforms for
SPACA6

Expression for SPACA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA6 Gene:

SPACA6

mRNA Expression by UniProt/SwissProt for SPACA6 Gene:

W5XKT8-SACA6_HUMAN
Tissue specificity: Expressed in testis.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA6 Gene

Orthologs for SPACA6 Gene

Evolution for SPACA6 Gene

ENSEMBL:
Gene Tree for SPACA6 (if available)
TreeFam:
Gene Tree for SPACA6 (if available)

No data available for Orthologs for SPACA6 Gene

Paralogs for SPACA6 Gene

No data available for Paralogs for SPACA6 Gene

Variants for SPACA6 Gene

Sequence variations from dbSNP and Humsavar for SPACA6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000008875 -- 51,707,601(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000024807 -- 51,701,726(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000035470 -- 51,705,721(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000093001 -- 51,690,920(+) /A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000157128 -- 51,687,100(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA6 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3644679 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Additional Variant Information for SPACA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA6 Gene

Disorders for SPACA6 Gene

No disorders were found for SPACA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA6 Gene

Publications for SPACA6 Gene

  1. A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion. (PMID: 24275887) Lorenzetti D … Bishop CE (Mammalian genome : official journal of the International Mammalian Genome Society 2014) 2 3 4 58
  2. Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes. (PMID: 23044541) Gascoigne DK … Mattick JS (Bioinformatics (Oxford, England) 2012) 2 3 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for SPACA6 Gene

Sources for SPACA6 Gene

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