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Aliases for SPACA5B Gene

Aliases for SPACA5B Gene

  • Sperm Acrosome Associated 5B 2 3 5
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • Sperm Acrosome-Associated Protein 5 3
  • EC 4
  • SPACA5A 4
  • LYZL5B 3
  • LYZL5 4

External Ids for SPACA5B Gene

Previous GeneCards Identifiers for SPACA5B Gene

  • GC0XP047873
  • GC0XP047986

Summaries for SPACA5B Gene

GeneCards Summary for SPACA5B Gene

SPACA5B (Sperm Acrosome Associated 5B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5.

Additional gene information for SPACA5B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5B Gene

Genomics for SPACA5B Gene

GeneHancer (GH) Regulatory Elements for SPACA5B Gene

Promoters and enhancers for SPACA5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048130 Promoter 0.5 EPDnew 550.8 0.0 -24 0.1 SPACA5B PIR56028
GH0XI048127 Enhancer 0.2 Ensembl 0.8 -3.4 -3356 0.6 SPACA5B PIR56028
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPACA5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPACA5B gene promoter:

Genomic Locations for SPACA5B Gene

Genomic Locations for SPACA5B Gene
1,957 bases
Plus strand

Genomic View for SPACA5B Gene

Genes around SPACA5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5B Gene

Proteins for SPACA5B Gene

  • Protein details for SPACA5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5B Gene

    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5B Gene

Post-translational modifications for SPACA5B Gene

No Post-translational modifications

Other Protein References for SPACA5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5B Gene

Domains & Families for SPACA5B Gene

Gene Families for SPACA5B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for SPACA5B Gene

Suggested Antigen Peptide Sequences for SPACA5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5B: view

Function for SPACA5B Gene

Molecular function for SPACA5B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Enzyme Numbers (IUBMB) for SPACA5B Gene

Gene Ontology (GO) - Molecular Function for SPACA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SPACA5B: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5B Gene

Localization for SPACA5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA5B gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPACA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SPACA5B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA5B Gene

Pathways & Interactions for SPACA5B Gene

SuperPathways for SPACA5B Gene

No Data Available

Interacting Proteins for SPACA5B Gene

Selected Interacting proteins: Q96QH8-LYZL5_HUMAN for SPACA5B Gene via IID

Gene Ontology (GO) - Biological Process for SPACA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with SPACA5B: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA5B Gene

Drugs & Compounds for SPACA5B Gene

No Compound Related Data Available

Transcripts for SPACA5B Gene

mRNA/cDNA for SPACA5B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5B Gene

No ASD Table

Relevant External Links for SPACA5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPACA5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPACA5B Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5B Gene

Protein tissue co-expression partners for SPACA5B Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA5B Gene:


SOURCE GeneReport for Unigene cluster for SPACA5B Gene:

genes like me logo Genes that share expression patterns with SPACA5B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA5B Gene

Orthologs for SPACA5B Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
  • 99.79 (n)
(Canis familiaris)
Mammalia SPACA5 33
  • 83.97 (n)
-- 34
  • 75 (a)
(Bos Taurus)
Mammalia SPACA5 33 34
  • 82.47 (n)
(Rattus norvegicus)
Mammalia Spaca5 33
  • 82.03 (n)
(Mus musculus)
Mammalia Spaca5 33 16 34
  • 80.22 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta LysP 34
  • 34 (a)
CG7798 34
  • 33 (a)
LysB 34
  • 33 (a)
LysE 34
  • 33 (a)
LysS 34
  • 33 (a)
CG11159 34
  • 32 (a)
LysC 34
  • 32 (a)
LysD 34
  • 32 (a)
LysX 34
  • 32 (a)
CG16756 34
  • 28 (a)
CG16799 34
  • 26 (a)
CG30062 34
  • 24 (a)
CG8492 34
  • 4 (a)
Species where no ortholog for SPACA5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5B Gene

Gene Tree for SPACA5B (if available)
Gene Tree for SPACA5B (if available)

Paralogs for SPACA5B Gene

Paralogs for SPACA5B Gene

(7) SIMAP similar genes for SPACA5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPACA5B: view

Variants for SPACA5B Gene

Sequence variations from dbSNP and Humsavar for SPACA5B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs142214372 -- 48,129,675(+) G/A upstream_transcript_variant
rs145718944 -- 48,129,674(+) C/T upstream_transcript_variant
rs146576176 -- 48,131,833(+) G/T intron_variant
rs147564853 -- 48,128,862(+) A/G upstream_transcript_variant
rs148504381 -- 48,130,203(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA5B Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
dgv2286e212 CNV gain 25503493
dgv2287e212 CNV loss 25503493
dgv37n14 CNV gain 18776910
dgv4586e59 CNV duplication 20981092
dgv4587e59 CNV duplication 20981092
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv34308 CNV gain 17911159
esv8782 OTHER inversion 19470904
nsv1119336 CNV duplication 24896259
nsv1145804 CNV duplication 26484159
nsv471601 CNV gain 15918152
nsv515198 CNV gain 21397061
nsv515200 CNV gain+loss 21397061
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680
nsv522886 CNV gain 19592680
nsv6890 CNV deletion 18451855
nsv6892 CNV insertion 18451855
nsv9938 CNV gain 18304495

Additional Variant Information for SPACA5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA5B Gene

Disorders for SPACA5B Gene

Additional Disease Information for SPACA5B

No disorders were found for SPACA5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5B Gene

Publications for SPACA5B Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen YT … Jongeneel CV (Genes, chromosomes & cancer 2006) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for SPACA5B Gene

Sources for SPACA5B Gene

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