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Aliases for SPACA5 Gene

Aliases for SPACA5 Gene

  • Sperm Acrosome Associated 5 2 3 5
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Sperm Lysozyme-Like Protein 2 2 3
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • LYZL5 3 4
  • Sperm Acrosome-Associated Protein 5 3
  • Testicular Tissue Protein Li 113 3
  • EC 3.2.1.17 4
  • PNPK6288 3
  • UNQ6288 3
  • SPACA5A 4
  • SLLP2 3
  • LYC5 3

External Ids for SPACA5 Gene

Previous GeneCards Identifiers for SPACA5 Gene

  • GC00U916482
  • GC0XP047750
  • GC0XP047864
  • GC0XP045698

Summaries for SPACA5 Gene

GeneCards Summary for SPACA5 Gene

SPACA5 (Sperm Acrosome Associated 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

Additional gene information for SPACA5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5 Gene

Genomics for SPACA5 Gene

GeneHancer (GH) Regulatory Elements for SPACA5 Gene

Promoters and enhancers for SPACA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ048002 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 -0.6 -570 2.5 CC2D1A ELF3 POLR2A GTF2F1 ZSCAN21 YY1 SP7 ELF1 SP1 CREM ZNF182 SPACA5 RBM10 UBA1 FTSJ1 ENSG00000228343 ZNF81 PQBP1 HDAC6 INE1
GH0XJ047523 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 1.2 -480.6 -480614 0.8 ZNF148 CTCF SP7 KLF14 RAD21 GMEB1 ZBTB33 ZNF600 ZIC2 ATF1 LINC01560 ZNF41 USP11 CDK16 ELK1 CFP SYN1 SPACA5 GC0XP047511 NUS1P1
GH0XJ048015 Enhancer 0.2 Ensembl 0.4 +11.2 11165 1 PIR35699 SPACA5 ZNF630
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPACA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPACA5 gene promoter:
  • AML1a
  • Evi-1
  • HFH-1
  • ISGF-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for SPACA5 Gene

Genomic Locations for SPACA5 Gene
chrX:48,004,336-48,010,162
(GRCh38/hg38)
Size:
5,827 bases
Orientation:
Plus strand
chrX:47,863,734-47,869,130
(GRCh37/hg19)
Size:
5,397 bases
Orientation:
Plus strand

Genomic View for SPACA5 Gene

Genes around SPACA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5 Gene

Proteins for SPACA5 Gene

  • Protein details for SPACA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH8-LYZL5_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Q96QH8
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5 Gene

    Size:
    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5 Gene

Post-translational modifications for SPACA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5 Gene

Domains & Families for SPACA5 Gene

Gene Families for SPACA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for SPACA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QH8

UniProtKB/Swiss-Prot:

LYZL5_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5: view

No data available for Suggested Antigen Peptide Sequences for SPACA5 Gene

Function for SPACA5 Gene

Molecular function for SPACA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;.

Enzyme Numbers (IUBMB) for SPACA5 Gene

Gene Ontology (GO) - Molecular Function for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SPACA5: view
genes like me logo Genes that share phenotypes with SPACA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA5

Clone Products

  • Applied Biological Materials (abm): Clones for SPACA5 - Now 50% OFF >
  • * SPACA5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPACA5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5 Gene

Localization for SPACA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA5 gene
Compartment Confidence
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA5 Gene

Pathways & Interactions for SPACA5 Gene

PathCards logo

SuperPathways for SPACA5 Gene

No Data Available

Interacting Proteins for SPACA5 Gene

Gene Ontology (GO) - Biological Process for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0050829 defense response to Gram-negative bacterium IBA 21873635
GO:0050830 defense response to Gram-positive bacterium IBA 21873635
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA5 Gene

Drugs & Compounds for SPACA5 Gene

(1) Drugs for SPACA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with SPACA5: view

Transcripts for SPACA5 Gene

mRNA/cDNA for SPACA5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA5

Clone Products

  • Applied Biological Materials (abm): Clones for SPACA5 - Now 50% OFF >
  • * SPACA5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPACA5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5 Gene

No ASD Table

Relevant External Links for SPACA5 Gene

GeneLoc Exon Structure for
SPACA5
ECgene alternative splicing isoforms for
SPACA5

Expression for SPACA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPACA5 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA5 Gene

This gene is overexpressed in Testis (x25.9).

Protein differential expression in normal tissues from HIPED for SPACA5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5 Gene



Protein tissue co-expression partners for SPACA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA5 Gene:

SPACA5
genes like me logo Genes that share expression patterns with SPACA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA5 Gene

Orthologs for SPACA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
SPACA5B 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia SPACA5 34
  • 83.97 (n)
-- 35
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SPACA5 35 34
  • 82.47 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Spaca5 34
  • 82.03 (n)
mouse
(Mus musculus)
Mammalia Spaca5 35 34
  • 80.22 (n)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta LysP 35
  • 34 (a)
ManyToMany
LysS 35
  • 33 (a)
ManyToMany
LysE 35
  • 33 (a)
ManyToMany
LysB 35
  • 33 (a)
ManyToMany
CG7798 35
  • 33 (a)
ManyToMany
CG11159 35
  • 32 (a)
ManyToMany
LysD 35
  • 32 (a)
ManyToMany
LysC 35
  • 32 (a)
ManyToMany
LysX 35
  • 32 (a)
ManyToMany
CG16756 35
  • 28 (a)
ManyToMany
CG16799 35
  • 26 (a)
ManyToMany
CG30062 35
  • 24 (a)
ManyToMany
CG8492 35
  • 4 (a)
ManyToMany
Species where no ortholog for SPACA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5 Gene

ENSEMBL:
Gene Tree for SPACA5 (if available)
TreeFam:
Gene Tree for SPACA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPACA5: view image

Paralogs for SPACA5 Gene

Paralogs for SPACA5 Gene

(7) SIMAP similar genes for SPACA5 Gene using alignment to 1 proteins:

  • LYZL5_HUMAN
genes like me logo Genes that share paralogs with SPACA5: view

Variants for SPACA5 Gene

Sequence variations from dbSNP and Humsavar for SPACA5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003688664 -- 48,003,454(+) C/T upstream_transcript_variant
rs1003762069 -- 48,002,949(+) G/A upstream_transcript_variant
rs1008275863 -- 48,003,921(+) A/C upstream_transcript_variant
rs1008329662 -- 48,004,110(+) G/A upstream_transcript_variant
rs1012499880 -- 48,003,464(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA5 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
dgv2286e212 CNV gain 25503493
dgv2287e212 CNV loss 25503493
dgv37n14 CNV gain 18776910
dgv4586e59 CNV duplication 20981092
dgv4587e59 CNV duplication 20981092
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv34308 CNV gain 17911159
esv8782 OTHER inversion 19470904
nsv1119336 CNV duplication 24896259
nsv1145804 CNV duplication 26484159
nsv471601 CNV gain 15918152
nsv515198 CNV gain 21397061
nsv515200 CNV gain+loss 21397061
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680
nsv522886 CNV gain 19592680
nsv6890 CNV deletion 18451855
nsv6892 CNV insertion 18451855
nsv9938 CNV gain 18304495

Additional Variant Information for SPACA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA5 Gene

Disorders for SPACA5 Gene

Additional Disease Information for SPACA5

No disorders were found for SPACA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5 Gene

Publications for SPACA5 Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen YT … Jongeneel CV (Genes, chromosomes & cancer 2006) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for SPACA5 Gene

Sources for SPACA5 Gene

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