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Aliases for SPACA5 Gene

Aliases for SPACA5 Gene

  • Sperm Acrosome Associated 5 2 3 5
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Sperm Lysozyme-Like Protein 2 2 3
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • LYZL5 3 4
  • Sperm Acrosome-Associated Protein 5 3
  • Testicular Tissue Protein Li 113 3
  • EC 4
  • PNPK6288 3
  • UNQ6288 3
  • SPACA5A 4
  • SLLP2 3
  • LYC5 3

External Ids for SPACA5 Gene

Previous GeneCards Identifiers for SPACA5 Gene

  • GC00U916482
  • GC0XP047750
  • GC0XP047864
  • GC0XP045698

Summaries for SPACA5 Gene

GeneCards Summary for SPACA5 Gene

SPACA5 (Sperm Acrosome Associated 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

Additional gene information for SPACA5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5 Gene

Genomics for SPACA5 Gene

GeneHancer (GH) Regulatory Elements for SPACA5 Gene

Promoters and enhancers for SPACA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048002 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.7 -670 2.3 ATF1 FOXA2 ZNF133 ARID4B FEZF1 ZNF2 BRCA1 YY1 ETS1 POLR2B SPACA5 ZNF182 ENSG00000228343 PIR34840 ZNF630 ZNF81
GH0XI047523 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -480.6 -480635 1 ATF1 ARID4B ZNF2 ZNF143 ATF7 RUNX3 DEK SP3 SP5 REST LINC01560 ZNF41 USP11 CDK16 ELK1 CFP SYN1 SPACA5 GC0XP047511 NUS1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPACA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPACA5 gene promoter:

Genomic Locations for SPACA5 Gene

Genomic Locations for SPACA5 Gene
5,827 bases
Plus strand

Genomic View for SPACA5 Gene

Genes around SPACA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5 Gene

Proteins for SPACA5 Gene

  • Protein details for SPACA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5 Gene

    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5 Gene

Post-translational modifications for SPACA5 Gene

No Post-translational modifications

Other Protein References for SPACA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5 Gene

Domains & Families for SPACA5 Gene

Gene Families for SPACA5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for SPACA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5: view

No data available for Suggested Antigen Peptide Sequences for SPACA5 Gene

Function for SPACA5 Gene

Molecular function for SPACA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Enzyme Numbers (IUBMB) for SPACA5 Gene

Phenotypes From GWAS Catalog for SPACA5 Gene

Gene Ontology (GO) - Molecular Function for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SPACA5: view

Phenotypes for SPACA5 Gene

genes like me logo Genes that share phenotypes with SPACA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5 Gene

Localization for SPACA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA5 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA5 Gene

Pathways & Interactions for SPACA5 Gene

SuperPathways for SPACA5 Gene

No Data Available

Interacting Proteins for SPACA5 Gene

Selected Interacting proteins: Q96QH8-LYZL5_HUMAN for SPACA5 Gene via IID

Gene Ontology (GO) - Biological Process for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA5 Gene

Drugs & Compounds for SPACA5 Gene

(1) Drugs for SPACA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with SPACA5: view

Transcripts for SPACA5 Gene

mRNA/cDNA for SPACA5 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5 Gene

No ASD Table

Relevant External Links for SPACA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPACA5 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA5 Gene

This gene is overexpressed in Testis (x25.9).

Protein differential expression in normal tissues from HIPED for SPACA5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5 Gene

Protein tissue co-expression partners for SPACA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA5 Gene:

genes like me logo Genes that share expression patterns with SPACA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA5 Gene

Orthologs for SPACA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
  • 99.79 (n)
(Canis familiaris)
Mammalia SPACA5 33
  • 83.97 (n)
-- 34
  • 75 (a)
(Bos Taurus)
Mammalia SPACA5 33 34
  • 82.47 (n)
(Rattus norvegicus)
Mammalia Spaca5 33
  • 82.03 (n)
(Mus musculus)
Mammalia Spaca5 33 34
  • 80.22 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta LysP 34
  • 34 (a)
CG7798 34
  • 33 (a)
LysB 34
  • 33 (a)
LysE 34
  • 33 (a)
LysS 34
  • 33 (a)
CG11159 34
  • 32 (a)
LysC 34
  • 32 (a)
LysD 34
  • 32 (a)
LysX 34
  • 32 (a)
CG16756 34
  • 28 (a)
CG16799 34
  • 26 (a)
CG30062 34
  • 24 (a)
CG8492 34
  • 4 (a)
Species where no ortholog for SPACA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5 Gene

Gene Tree for SPACA5 (if available)
Gene Tree for SPACA5 (if available)

Paralogs for SPACA5 Gene

Paralogs for SPACA5 Gene

(7) SIMAP similar genes for SPACA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPACA5: view

Variants for SPACA5 Gene

Sequence variations from dbSNP and Humsavar for SPACA5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003688664 -- 48,003,454(+) C/T upstream_transcript_variant
rs1003762069 -- 48,002,949(+) G/A upstream_transcript_variant
rs1008275863 -- 48,003,921(+) A/C upstream_transcript_variant
rs1008329662 -- 48,004,110(+) G/A upstream_transcript_variant
rs1012499880 -- 48,003,464(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA5 Gene

Variant ID Type Subtype PubMed ID
nsv9938 CNV gain 18304495
nsv6892 CNV insertion 18451855
nsv6890 CNV deletion 18451855
nsv522886 CNV gain 19592680
nsv521227 CNV gain 19592680
nsv519165 CNV loss 19592680
nsv517350 CNV gain+loss 19592680
nsv515200 CNV gain+loss 21397061
nsv515198 CNV gain 21397061
nsv471601 CNV gain 15918152
nsv1145804 CNV duplication 26484159
nsv1119336 CNV duplication 24896259
esv8782 OTHER inversion 19470904
esv34308 CNV gain 17911159
esv32909 CNV gain+loss 17666407
esv2758866 CNV gain+loss 17122850
esv2752324 CNV gain 17911159
esv25781 CNV gain 19812545
dgv4587e59 CNV duplication 20981092
dgv4586e59 CNV duplication 20981092
dgv37n14 CNV gain 18776910
dgv2287e212 CNV loss 25503493
dgv2286e212 CNV gain 25503493
dgv17n29 CNV gain+loss 16826518

Additional Variant Information for SPACA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA5 Gene

Disorders for SPACA5 Gene

Additional Disease Information for SPACA5

No disorders were found for SPACA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5 Gene

Publications for SPACA5 Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen YT … Jongeneel CV (Genes, chromosomes & cancer 2006) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for SPACA5 Gene

Sources for SPACA5 Gene

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