SPACA5 Gene (Protein Coding)

Sperm Acrosome Associated 5

GC0XP048005
GIFtS:
29
See more...

Aliases for SPACA5 Gene

Aliases for SPACA5 Gene

  • Sperm Acrosome Associated 5 2 3 5
  • LYZL5 2 3 4
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Sperm Acrosome-Associated Protein 5 3 4
  • Sperm Lysozyme-Like Protein 2 2 3
  • Lysozyme-Like Protein 5 3 4
  • PNPK6288 2 3
  • UNQ6288 2 3
  • SLLP-X 3 4
  • SLLP2 2 3
  • LYC5 2 3
  • Testicular Tissue Protein Li 113 3
  • EC 3.2.1.17 4
  • DJ54B20.3 2
  • SPACA5A 4
  • SPACA5 5

External Ids for SPACA5 Gene

Previous GeneCards Identifiers for SPACA5 Gene

  • GC00U916482
  • GC0XP047750
  • GC0XP047864
  • GC0XP045698

Summaries for SPACA5 Gene

GeneCards Summary for SPACA5 Gene

SPACA5 (Sperm Acrosome Associated 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

Additional gene information for SPACA5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPACA5 Gene

Genomics for SPACA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SPACA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ048002 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -1.0 -1035 3.4 CREB1 ATF7 PRDM10 ZNF629 ZNF692 POLR2A ZNF7 JUND FOXA1 PRDM1 ZNF182 SPACA5 ZNF630 ENSG00000228343 RF00017-8405 ZNF81
GH0XJ047523 Promoter/Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 1.2 -480.7 -480676 0.9 CTCF ZNF692 ZNF143 ZIC2 POLR2A PATZ1 REST RAD21 ZNF501 TRIM22 ZNF41 LINC01560 CDK16 USP11 ELK1 CFP SYN1 SPACA5 NUS1P1 lnc-SYN1-2
GH0XJ048020 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 0.4 +17.2 17153 1.9 ZNF221 SP1 ATF7 PRDM10 ZNF692 JUND FOXA1 PRDM1 YY1 PKNOX1 HSALNG0137751 LINC01560 ZNF630 ZNF182 UXT-AS1 HDAC6 SYN1 RF00017-8407 SPACA5
GH0XJ048070 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +67.2 67226 1.9 SP1 CREB1 PRDM10 ZHX2 DDX20 PKNOX1 POLR2A REST IKZF2 PBX2 ZNF630 ENSG00000287757 SPACA5
GH0XJ048025 Enhancer 0.9 Ensembl ENCODE 0.4 +22.0 21965 1.8 CREB1 CTCF ZNF143 REST RAD21 ZNF501 TRIM22 RUNX3 NFE2 CEBPB RF00017-8407 ZNF630 piR-61945-532 SPACA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPACA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPACA5

Top Transcription factor binding sites by QIAGEN in the SPACA5 gene promoter:
  • AML1a
  • Evi-1
  • HFH-1
  • ISGF-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for SPACA5 Gene

Genomic Locations for SPACA5 Gene
chrX:48,004,336-48,009,736
(GRCh38/hg38)
Size:
5,401 bases
Orientation:
Plus strand
chrX:47,863,734-47,869,130
(GRCh37/hg19)
Size:
5,397 bases
Orientation:
Plus strand

Genomic View for SPACA5 Gene

Genes around SPACA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPACA5 Gene

Proteins for SPACA5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SPACA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH8-LYZL5_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Q96QH8
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5 Gene

    Size:
    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5 Gene

Protein Expression for SPACA5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SPACA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5 Gene

Domains & Families for SPACA5 Gene

Gene Families for SPACA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for SPACA5 Gene

InterPro:
Blocks:
  • Lysozyme signature
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96QH8

UniProtKB/Swiss-Prot:

LYZL5_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5: view

No data available for Suggested Antigen Peptide Sequences for SPACA5 Gene

Function for SPACA5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SPACA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;.

Enzyme Numbers (IUBMB) for SPACA5 Gene

Gene Ontology (GO) - Molecular Function for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SPACA5: view
genes like me logo Genes that share phenotypes with SPACA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA5

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5 Gene

Localization for SPACA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA5 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA5 Gene

Pathways & Interactions for SPACA5 Gene

PathCards logo

SuperPathways for SPACA5 Gene

No Data Available

Interacting Proteins for SPACA5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000305847 Q96QH8-LYZL5_HUMAN for SPACA5 Gene via STRING IID

GPS-Prot Interaction Network for SPACA5

Gene Ontology (GO) - Biological Process for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0050829 defense response to Gram-negative bacterium IBA 21873635
GO:0050830 defense response to Gram-positive bacterium IBA 21873635
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA5 Gene

Drugs & Compounds for SPACA5 Gene

Products:

  1. Drug

(1) Drugs for SPACA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with SPACA5: view

Transcripts for SPACA5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SPACA5 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA5

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5 Gene

No ASD Table

Relevant External Links for SPACA5 Gene

GeneLoc Exon Structure for
SPACA5

Expression for SPACA5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPACA5 Gene

mRNA expression in normal human tissues for SPACA5 Gene
mRNA expression by BioGPS for SPACA5 GenemRNA expression by GTEx for SPACA5 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA5 Gene

This gene is overexpressed in Testis (x25.9).

Protein differential expression in normal tissues from HIPED for SPACA5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5 Gene



Protein tissue co-expression partners for SPACA5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPACA5

genes like me logo Genes that share expression patterns with SPACA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA5 Gene

Orthologs for SPACA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 100 (a)
 OneToMany
SPACA5B 30
  • 99.79 (n)
Dog
(Canis familiaris)
 Mammalia SPACA5 30
  • 83.97 (n)
-- 31
  • 75 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia SPACA5 30 31
  • 82.47 (n)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Spaca5 30
  • 82.03 (n)
Mouse
(Mus musculus)
 Mammalia Spaca5 30 31
  • 80.22 (n)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 51 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 43 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta LysP 31
  • 34 (a)
 ManyToMany
LysS 31
  • 33 (a)
 ManyToMany
LysE 31
  • 33 (a)
 ManyToMany
LysB 31
  • 33 (a)
 ManyToMany
CG7798 31
  • 33 (a)
 ManyToMany
CG11159 31
  • 32 (a)
 ManyToMany
LysD 31
  • 32 (a)
 ManyToMany
LysC 31
  • 32 (a)
 ManyToMany
LysX 31
  • 32 (a)
 ManyToMany
CG16756 31
  • 28 (a)
 ManyToMany
CG16799 31
  • 26 (a)
 ManyToMany
CG30062 31
  • 24 (a)
 ManyToMany
CG8492 31
  • 4 (a)
 ManyToMany
Species where no ortholog for SPACA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPACA5 Gene

ENSEMBL:
Gene Tree for SPACA5 (if available)
TreeFam:
Gene Tree for SPACA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPACA5: view image

Paralogs for SPACA5 Gene

Paralogs for SPACA5 Gene

(7) SIMAP similar genes for SPACA5 Gene using alignment to 1 proteins:

  • LYZL5_HUMAN
genes like me logo Genes that share paralogs with SPACA5: view

Variants for SPACA5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for SPACA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPACA5 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
dgv2286e212 CNV gain 25503493
dgv2287e212 CNV loss 25503493
dgv37n14 CNV gain 18776910
dgv4586e59 CNV duplication 20981092
dgv4587e59 CNV duplication 20981092
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv34308 CNV gain 17911159
esv8782 OTHER inversion 19470904
nsv1119336 CNV duplication 24896259
nsv1145804 CNV duplication 26484159
nsv471601 CNV gain 15918152
nsv515198 CNV gain 21397061
nsv515200 CNV gain+loss 21397061
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680
nsv522886 CNV gain 19592680
nsv6890 CNV deletion 18451855
nsv6892 CNV insertion 18451855
nsv9938 CNV gain 18304495

Additional Variant Information for SPACA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SPACA5 Gene

Disorders for SPACA5 Gene

Additional Disease Information for SPACA5

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for SPACA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5 Gene

Publications for SPACA5 Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen YT … Jongeneel CV (Genes, chromosomes & cancer 2006) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4

ExternalLinks

View latest publications for SPACA5 gene in Mastermind

Products for SPACA5 Gene

Sources for SPACA5 Gene