Aliases for SPACA4 Gene

Aliases for SPACA4 Gene

  • Sperm Acrosome Associated 4 2 3 5
  • SAMP14 2 3 4
  • Sperm Acrosomal Membrane-Associated Protein 14 3 4
  • Sperm Acrosome Membrane-Associated Protein 4 3 4
  • Sperm Acrosomal Membrane Protein 14 3
  • Testicular Tissue Protein Li 167 3
  • SPACA4 5

External Ids for SPACA4 Gene

Previous GeneCards Identifiers for SPACA4 Gene

  • GC00U991082
  • GC19M049478
  • GC19P053786
  • GC19P053801
  • GC19P049110
  • GC19P045489

Summaries for SPACA4 Gene

GeneCards Summary for SPACA4 Gene

SPACA4 (Sperm Acrosome Associated 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot Summary for SPACA4 Gene

  • Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

Additional gene information for SPACA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPACA4 Gene

Genomics for SPACA4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPACA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048632 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +29.7 29735 7.8 BRCA1 RNF2 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 SEC1P DBP NONHSAG026179.2 PRR12 SNRNP70 GRWD1 ENSG00000268093 EHD2 NOP53-AS1 PIH1D1
GH19J048628 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.8 +23.7 23733 3.1 HNRNPL GATAD2A TEAD4 RFX1 RBFOX2 POLR2A ZNF600 CEBPA CTCF RFX3 SPACA4 FUT2 MAMSTR SEC1P DBP ENSG00000268093 SPHK2 RF00017-3047
GH19J048145 Enhancer 0.5 FANTOM5 Ensembl 50.5 -461.3 -461341 2 RFX1 ZFP36 ENSG00000269321 LOC107985293 SPACA4 SYNGR4 PLA2G4C LIG1
GH19J048328 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -275.0 -274956 6 SP1 CREB1 CTCF HNRNPL PRDM10 ZNF629 ZNF512 SIX5 LEF1 IKZF1 BICRA GRWD1 TMEM143 SNRNP70 NOP53-AS1 CA11 SYNGR4 NOP53 KDELR1 RPL18
GH19J048601 Enhancer 0.8 Ensembl ENCODE 10.2 -4.4 -4376 2.1 ZNF512 IKZF1 PRDM1 SP1 ZNF444 KLF4 GATAD2B DPF2 ELF1 SPI1 RF00017-3049 SPACA4 SEC1P FAM83E SULT2B1 RF00017-3047
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPACA4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPACA4

Top Transcription factor binding sites by QIAGEN in the SPACA4 gene promoter:
  • AML1a
  • AP-4
  • CP2
  • LUN-1
  • Nkx5-1
  • p53
  • PPAR-alpha
  • RORalpha1
  • ZIC2

Genomic Locations for SPACA4 Gene

Genomic Locations for SPACA4 Gene
chr19:48,606,742-48,607,714
(GRCh38/hg38)
Size:
973 bases
Orientation:
Plus strand
chr19:49,110,000-49,110,971
(GRCh37/hg19)
Size:
972 bases
Orientation:
Plus strand

Genomic View for SPACA4 Gene

Genes around SPACA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA4 Gene

Proteins for SPACA4 Gene

  • Protein details for SPACA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDM5-SACA4_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 4
    Protein Accession:
    Q8TDM5

    Protein attributes for SPACA4 Gene

    Size:
    124 amino acids
    Molecular mass:
    13004 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA4 Gene

Post-translational modifications for SPACA4 Gene

No Post-translational modifications

Other Protein References for SPACA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA4 Gene

Domains & Families for SPACA4 Gene

Gene Families for SPACA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPACA4 Gene

InterPro:
Blocks:
  • CD59 antigen
ProtoNet:

Suggested Antigen Peptide Sequences for SPACA4 Gene

GenScript: Design optimal peptide antigens:
  • Sperm acrosomal membrane-associated protein 14 (SACA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDM5

UniProtKB/Swiss-Prot:

SACA4_HUMAN :
  • Belongs to the SPACA4/bouncer family.
Family:
  • Belongs to the SPACA4/bouncer family.
genes like me logo Genes that share domains with SPACA4: view

Function for SPACA4 Gene

Molecular function for SPACA4 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

Phenotypes From GWAS Catalog for SPACA4 Gene

Phenotypes for SPACA4 Gene

genes like me logo Genes that share phenotypes with SPACA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA4 Gene

Localization for SPACA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA4 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes. {ECO:0000269 PubMed:12788941}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA4 gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SPACA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA4 Gene

Pathways & Interactions for SPACA4 Gene

genes like me logo Genes that share pathways with SPACA4: view

Gene Ontology (GO) - Biological Process for SPACA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SPACA4: view

No data available for SIGNOR curated interactions for SPACA4 Gene

Drugs & Compounds for SPACA4 Gene

No Compound Related Data Available

Transcripts for SPACA4 Gene

mRNA/cDNA for SPACA4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPACA4

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA4 Gene

No ASD Table

Relevant External Links for SPACA4 Gene

GeneLoc Exon Structure for
SPACA4

Expression for SPACA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPACA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SPACA4 Gene

This gene is overexpressed in Testis (x43.4).

Protein differential expression in normal tissues from HIPED for SPACA4 Gene

This gene is overexpressed in Testis (58.9) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA4 Gene



Protein tissue co-expression partners for SPACA4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPACA4

SOURCE GeneReport for Unigene cluster for SPACA4 Gene:

Hs.122599

mRNA Expression by UniProt/SwissProt for SPACA4 Gene:

Q8TDM5-SACA4_HUMAN
Tissue specificity: Testis specific (PubMed:12788941). Expressed in spermatozoa (PubMed:12788941).

Evidence on tissue expression from TISSUES for SPACA4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SPACA4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA4 Gene

Orthologs for SPACA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPACA4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPACA4 30 31
  • 98.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPACA4 30 31
  • 83.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPACA4 30 31
  • 79.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spaca4 30 17 31
  • 74.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spaca4 30
  • 74.14 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SPACA4 31
  • 52 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SPACA4 31
  • 43 (a)
OneToOne
Species where no ortholog for SPACA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPACA4 Gene

ENSEMBL:
Gene Tree for SPACA4 (if available)
TreeFam:
Gene Tree for SPACA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPACA4: view image

Paralogs for SPACA4 Gene

No data available for Paralogs for SPACA4 Gene

Variants for SPACA4 Gene

Additional dbSNP identifiers (rs#s) for SPACA4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPACA4 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
dgv666e214 CNV loss 21293372
esv3644594 CNV gain 21293372
nsv1057580 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for SPACA4 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPACA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPACA4 Gene

Disorders for SPACA4 Gene

No disorders were found for SPACA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA4 Gene

Publications for SPACA4 Gene

  1. SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. (PMID: 12788941) Shetty J … Herr JC (The Journal of biological chemistry 2003) 2 3 4 23
  2. The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization. (PMID: 30190407) Herberg S … Pauli A (Science (New York, N.Y.) 2018) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. (PMID: 30097533) Schiza C … Diamandis EP (Molecular & cellular proteomics : MCP 2018) 3

Products for SPACA4 Gene

Sources for SPACA4 Gene