Aliases for SPACA4 Gene

Aliases for SPACA4 Gene

  • Sperm Acrosome Associated 4 2 3 5
  • Sperm Acrosomal Membrane-Associated Protein 14 3 4
  • Sperm Acrosome Membrane-Associated Protein 4 3 4
  • SAMP14 3 4
  • Sperm Acrosomal Membrane Protein 14 3
  • Testicular Tissue Protein Li 167 3

External Ids for SPACA4 Gene

Previous GeneCards Identifiers for SPACA4 Gene

  • GC00U991082
  • GC19M049478
  • GC19P053786
  • GC19P053801
  • GC19P049110
  • GC19P045489

Summaries for SPACA4 Gene

GeneCards Summary for SPACA4 Gene

SPACA4 (Sperm Acrosome Associated 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot Summary for SPACA4 Gene

  • Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

Additional gene information for SPACA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPACA4 Gene

Genomics for SPACA4 Gene

GeneHancer (GH) Regulatory Elements for SPACA4 Gene

Promoters and enhancers for SPACA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048632 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +29.7 29735 7.8 SIN3A ZNF24 ZBTB40 SP1 CTCF SREBF1 SIX5 MLX SMARCE1 RBPJ SEC1P DBP NONHSAG026179.2 PRR12 SNRNP70 GRWD1 NOP53-AS1 EHD2 ALDH16A1 SNORD35B
GH19J048628 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.7 +23.7 23733 3.1 HLF CEBPG ZBTB33 CEBPA RFX1 GATAD2A CEBPB POLR2A CTCF CHD2 SPACA4 FUT2 MAMSTR SEC1P DBP ENSG00000268093 SPHK2 RF00017-3045
GH19J048328 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -275.0 -274956 6 SP1 ZBTB40 CTCF SREBF1 SIX5 LCORL FOXA1 POLR2A CEBPZ USF2 BICRA GRWD1 NOP53-AS1 SNRNP70 KDELR1 CYTH2 NOP53 RPL18 TMEM143 SNORD23
GH19J048145 Enhancer 0.5 FANTOM5 Ensembl 50.5 -461.3 -461341 2 RFX1 ENSG00000269321 SPACA4 SYNGR4 PLA2G4C LIG1 HSALNG0126834
GH19J048601 Enhancer 0.7 Ensembl ENCODE 10.2 -4.4 -4376 2.1 PRDM1 IKZF1 ZNF512 SP1 KLF4 DPF2 GATAD2B ZNF366 ELF1 ZBTB7B RF00017-3047 SPACA4 SEC1P FAM83E RF00017-3045
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPACA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPACA4 gene promoter:
  • AML1a
  • AP-4
  • CP2
  • LUN-1
  • Nkx5-1
  • p53
  • PPAR-alpha
  • RORalpha1
  • ZIC2

Genomic Locations for SPACA4 Gene

Genomic Locations for SPACA4 Gene
chr19:48,606,742-48,607,714
(GRCh38/hg38)
Size:
973 bases
Orientation:
Plus strand
chr19:49,110,000-49,110,971
(GRCh37/hg19)
Size:
972 bases
Orientation:
Plus strand

Genomic View for SPACA4 Gene

Genes around SPACA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA4 Gene

Proteins for SPACA4 Gene

  • Protein details for SPACA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDM5-SACA4_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 4
    Protein Accession:
    Q8TDM5

    Protein attributes for SPACA4 Gene

    Size:
    124 amino acids
    Molecular mass:
    13004 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA4 Gene

Post-translational modifications for SPACA4 Gene

No Post-translational modifications

Other Protein References for SPACA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA4 Gene

Domains & Families for SPACA4 Gene

Gene Families for SPACA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SPACA4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPACA4 Gene

GenScript: Design optimal peptide antigens:
  • Sperm acrosomal membrane-associated protein 14 (SACA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDM5

UniProtKB/Swiss-Prot:

SACA4_HUMAN :
  • Belongs to the SPACA4/bouncer family.
Family:
  • Belongs to the SPACA4/bouncer family.
genes like me logo Genes that share domains with SPACA4: view

Function for SPACA4 Gene

Molecular function for SPACA4 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

Phenotypes From GWAS Catalog for SPACA4 Gene

genes like me logo Genes that share phenotypes with SPACA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA4 Gene

Localization for SPACA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA4 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes. {ECO:0000269 PubMed:12788941}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA4 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SPACA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA4 Gene

Pathways & Interactions for SPACA4 Gene

genes like me logo Genes that share pathways with SPACA4: view

Gene Ontology (GO) - Biological Process for SPACA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SPACA4: view

No data available for SIGNOR curated interactions for SPACA4 Gene

Drugs & Compounds for SPACA4 Gene

No Compound Related Data Available

Transcripts for SPACA4 Gene

mRNA/cDNA for SPACA4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA4 Gene

No ASD Table

Relevant External Links for SPACA4 Gene

GeneLoc Exon Structure for
SPACA4
ECgene alternative splicing isoforms for
SPACA4

Expression for SPACA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPACA4 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA4 Gene

This gene is overexpressed in Testis (x43.4).

Protein differential expression in normal tissues from HIPED for SPACA4 Gene

This gene is overexpressed in Testis (58.9) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA4 Gene



Protein tissue co-expression partners for SPACA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPACA4 Gene:

SPACA4

SOURCE GeneReport for Unigene cluster for SPACA4 Gene:

Hs.122599

mRNA Expression by UniProt/SwissProt for SPACA4 Gene:

Q8TDM5-SACA4_HUMAN
Tissue specificity: Testis specific (PubMed:12788941). Expressed in spermatozoa (PubMed:12788941).

Evidence on tissue expression from TISSUES for SPACA4 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SPACA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA4 Gene

Orthologs for SPACA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPACA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPACA4 33 32
  • 98.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SPACA4 33 32
  • 83.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPACA4 33 32
  • 79.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Spaca4 17 33 32
  • 74.86 (n)
rat
(Rattus norvegicus)
Mammalia Spaca4 32
  • 74.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPACA4 33
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPACA4 33
  • 43 (a)
OneToOne
Species where no ortholog for SPACA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA4 Gene

ENSEMBL:
Gene Tree for SPACA4 (if available)
TreeFam:
Gene Tree for SPACA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPACA4: view image

Paralogs for SPACA4 Gene

No data available for Paralogs for SPACA4 Gene

Variants for SPACA4 Gene

Sequence variations from dbSNP and Humsavar for SPACA4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1002689455 -- 48,606,704(+) C/T upstream_transcript_variant
rs1003024631 -- 48,606,969(+) C/A 5_prime_UTR_variant
rs1004006337 -- 48,606,903(+) T/G 5_prime_UTR_variant
rs1004333733 -- 48,606,109(+) G/A upstream_transcript_variant
rs1005234034 -- 48,607,545(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA4 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
dgv666e214 CNV loss 21293372
esv3644594 CNV gain 21293372
nsv1057580 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for SPACA4 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPACA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA4 Gene

Disorders for SPACA4 Gene

Additional Disease Information for SPACA4

No disorders were found for SPACA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA4 Gene

Publications for SPACA4 Gene

  1. SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. (PMID: 12788941) Shetty J … Herr JC (The Journal of biological chemistry 2003) 2 3 4 23 56
  2. The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization. (PMID: 30190407) Herberg S … Pauli A (Science (New York, N.Y.) 2018) 2 3 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for SPACA4 Gene

Sources for SPACA4 Gene