Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPACA1 Gene

Aliases for SPACA1 Gene

  • Sperm Acrosome Associated 1 2 3 5
  • Sperm Acrosomal Membrane-Associated Protein 32 3 4
  • SAMP32 3 4
  • Sperm Acrosome Membrane-Associated Protein 1 3

External Ids for SPACA1 Gene

Previous GeneCards Identifiers for SPACA1 Gene

  • GC06P088703
  • GC06P088753
  • GC06P088814
  • GC06P085972
  • GC06P088757

Summaries for SPACA1 Gene

Entrez Gene Summary for SPACA1 Gene

  • The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPACA1 Gene

SPACA1 (Sperm Acrosome Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA1 Gene

  • May be involved in sperm-egg fusion.

Additional gene information for SPACA1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA1 Gene

Genomics for SPACA1 Gene

GeneHancer (GH) Regulatory Elements for SPACA1 Gene

Promoters and enhancers for SPACA1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I088047 Promoter 0.6 EPDnew 550.8 +0.8 787 0.1 GABPB1 SPACA1 GC06M088140
GH06I088008 Enhancer 0.8 Ensembl ENCODE 11.8 -38.0 -37984 1.3 ZNF189 ZBTB11 TSHZ1 FOS FOSL2 PRDM10 ZBTB17 TRIM28 SPACA1 CNR1 LOC105377882
GH06I088141 Enhancer 0.7 ENCODE 0.2 +95.0 94959 1.2 CBFB NR2F1 CEBPB EBF1 CEBPG DPF2 ATF2 RELA POLR2A IKZF1 GC06M088140 CNR1 SPACA1
GH06I087968 Enhancer 0.6 Ensembl 0.2 -78.3 -78334 0.6 CTCF MAZ ZNF777 ZBTB8A ZIC2 ZNF664 ZNF335 GLIS2 POLR2A GLIS1 LOC105377882 SPACA1
GH06I087944 Enhancer 1.1 Ensembl ENCODE 0.1 -101.9 -101938 1.6 FEZF1 ZNF2 ZNF213 FOS ATF7 TSHZ1 ZNF488 ZNF518A ZNF610 GLIS1 LOC105377882 SPACA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPACA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPACA1 gene promoter:

Genomic Locations for SPACA1 Gene

Genomic Locations for SPACA1 Gene
19,798 bases
Plus strand

Genomic View for SPACA1 Gene

Genes around SPACA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA1 Gene

Proteins for SPACA1 Gene

  • Protein details for SPACA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome membrane-associated protein 1
    Protein Accession:

    Protein attributes for SPACA1 Gene

    294 amino acids
    Molecular mass:
    32143 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA1 Gene

Post-translational modifications for SPACA1 Gene

  • Glycosylation at isoforms=31
  • Modification sites at PhosphoSitePlus

Other Protein References for SPACA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA1 Gene

Domains & Families for SPACA1 Gene

Gene Families for SPACA1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPACA1 Gene


Suggested Antigen Peptide Sequences for SPACA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA1: view

No data available for UniProtKB/Swiss-Prot for SPACA1 Gene

Function for SPACA1 Gene

Molecular function for SPACA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sperm-egg fusion.

Phenotypes From GWAS Catalog for SPACA1 Gene

Gene Ontology (GO) - Molecular Function for SPACA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
genes like me logo Genes that share ontologies with SPACA1: view
genes like me logo Genes that share phenotypes with SPACA1: view

Animal Models for SPACA1 Gene

MGI Knock Outs for SPACA1:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA1 Gene

Localization for SPACA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA1 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for SPACA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005615 extracellular space IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA1 Gene

Pathways & Interactions for SPACA1 Gene

SuperPathways for SPACA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPACA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0007283 spermatogenesis IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with SPACA1: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA1 Gene

Drugs & Compounds for SPACA1 Gene

No Compound Related Data Available

Transcripts for SPACA1 Gene

mRNA/cDNA for SPACA1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPACA1 Gene

Sperm acrosome associated 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -

Relevant External Links for SPACA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPACA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPACA1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for SPACA1 Gene

This gene is overexpressed in Testis (43.2) and Ovary (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPACA1 Gene

Protein tissue co-expression partners for SPACA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPACA1 Gene:


SOURCE GeneReport for Unigene cluster for SPACA1 Gene:


mRNA Expression by UniProt/SwissProt for SPACA1 Gene:

Tissue specificity: Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm.
genes like me logo Genes that share expression patterns with SPACA1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA1 Gene

Orthologs for SPACA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPACA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPACA1 33 34
  • 98.3 (n)
(Bos Taurus)
Mammalia SPACA1 33 34
  • 84.12 (n)
(Canis familiaris)
Mammalia SPACA1 33 34
  • 83.62 (n)
(Rattus norvegicus)
Mammalia Spaca1 33
  • 78.61 (n)
(Mus musculus)
Mammalia Spaca1 33 16 34
  • 76.56 (n)
(Monodelphis domestica)
Mammalia SPACA1 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia SPACA1 34
  • 54 (a)
(Gallus gallus)
Aves SPACA1 33 34
  • 63.73 (n)
(Anolis carolinensis)
Reptilia SPACA1 34
  • 43 (a)
Species where no ortholog for SPACA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA1 Gene

Gene Tree for SPACA1 (if available)
Gene Tree for SPACA1 (if available)

Paralogs for SPACA1 Gene

No data available for Paralogs for SPACA1 Gene

Variants for SPACA1 Gene

Sequence variations from dbSNP and Humsavar for SPACA1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000025312 -- 88,052,164(+) C/G/T intron_variant
rs1000089501 -- 88,044,999(+) A/G upstream_transcript_variant
rs1000297305 -- 88,057,834(+) C/A intron_variant
rs1000587066 -- 88,045,217(+) A/C upstream_transcript_variant
rs1000643946 -- 88,062,683(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA1 Gene

Variant ID Type Subtype PubMed ID
esv2732394 CNV deletion 23290073

Variation tolerance for SPACA1 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPACA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA1 Gene

Disorders for SPACA1 Gene

Additional Disease Information for SPACA1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPACA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA1 Gene

Publications for SPACA1 Gene

  1. SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein. (PMID: 11870081) Hao Z … Herr JC (Biology of reproduction 2002) 3 4 22 58
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for SPACA1 Gene

Sources for SPACA1 Gene

Loading form....