Aliases for SPA17 Gene
Aliases for SPA17 Gene
External Ids for SPA17 Gene
- HGNC: 11210
- Entrez Gene: 53340
- Ensembl: ENSG00000064199
- OMIM: 608621
- UniProtKB: Q15506
Previous GeneCards Identifiers for SPA17 Gene
- GC11P126544
- GC11P126057
- GC11P124577
- GC11P124081
- GC11P124048
- GC11P120486
- GC11P124545
Summaries for SPA17 Gene
-
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
GeneCards Summary for SPA17 Gene
SPA17 (Sperm Autoantigenic Protein 17) is a Protein Coding gene. Diseases associated with SPA17 include Ovarian Cancer. Gene Ontology (GO) annotations related to this gene include calmodulin binding.
UniProtKB/Swiss-Prot for SPA17 Gene
-
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPA17 Gene
Genomics for SPA17 Gene
GeneHancer (GH) Regulatory Elements for SPA17 Gene
Promoters and enhancers for SPA17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SPA17 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SPA17 gene promoter:
Regulatory Element Products
Genomic Locations for SPA17 Gene
Genomic Locations for SPA17 Gene
- chr11:124,673,798-124,697,545
- (GRCh38/hg38)
- Size:
- 23,748 bases
- Orientation:
- Plus strand
- chr11:124,543,694-124,567,414
- (GRCh37/hg19)
Genomic View for SPA17 Gene
Genes around SPA17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.2 by Ensembl
- 11q24.2 by Entrez Gene
- 11q24.2 by HGNC
SPA17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPA17 Gene
Proteins for SPA17 Gene
-
Protein details for SPA17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15506-SP17_HUMAN
- Recommended name:
- Sperm surface protein Sp17
- Protein Accession:
- Q15506
- B2R4F2
- Q9BXF7
Protein attributes for SPA17 Gene
- Size:
- 151 amino acids
- Molecular mass:
- 17406 Da
- Quaternary structure:
-
- Homodimer (By similarity). May interact with ROPN1.
Protein Expression for SPA17 Gene
Post-translational modifications for SPA17 Gene
Other Protein References for SPA17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SPA17
-
Abcam antibodies for SPA17
-
Cloud-Clone Corp. Antibodies for SPA17
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- GeneTex SPA17 antibody for SPA17
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPA17
Protein Products
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OriGene Purified Proteins for SPA17
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- ProSpec Recombinant Proteins for SPA17
-
Cloud-Clone Corp. Proteins for SPA17
- Search GeneTex for Proteins for SPA17
-
Abcam proteins for SPA17
Assay Products
No data available for DME Specific Peptides for SPA17 Gene
Domains & Families for SPA17 Gene
Gene Families for SPA17 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SPA17 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPA17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SPA17 Gene
Function for SPA17 Gene
Molecular function for SPA17 Gene
- UniProtKB/Swiss-Prot Function:
- Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).
Phenotypes From GWAS Catalog for SPA17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15257753 |
Phenotypes for SPA17 Gene
- GenomeRNAi human phenotypes for SPA17:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPA17 gene
-
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- Search ViGene Biosciences for SPA17
CRISPR Products
-
OriGene CRISPR knockouts for SPA17
- genomics-online: gRNA clones - Search results for 85 available SPA17 gene related products
- Overview of 85 available SPA17 gene related products
- Applied Biological Materials CRISPR for SPA17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPA17
- GenScript: Design CRISPR guide RNA sequences for SPA17
miRNA for SPA17 Gene
- miRTarBase miRNAs that target SPA17
-
- hsa-mir-4535 (MIRT525969)
- hsa-mir-376a-2-5p (MIRT525970)
- hsa-mir-3935 (MIRT525971)
- hsa-mir-659-5p (MIRT525972)
- hsa-mir-492 (MIRT525973)
- hsa-mir-6861-3p (MIRT525974)
- hsa-mir-3171 (MIRT525975)
- hsa-mir-422a (MIRT525976)
- hsa-mir-378i (MIRT525977)
- hsa-mir-378h (MIRT525978)
- hsa-mir-378f (MIRT525979)
- hsa-mir-378e (MIRT525980)
- hsa-mir-378d (MIRT525981)
- hsa-mir-378c (MIRT525982)
- hsa-mir-378b (MIRT525983)
- hsa-mir-378a-3p (MIRT525984)
- hsa-mir-4638-3p (MIRT525985)
- hsa-mir-3668 (MIRT525986)
- hsa-mir-1298-3p (MIRT525987)
- hsa-mir-3126-3p (MIRT525988)
- hsa-mir-3154 (MIRT525989)
- hsa-mir-7152-5p (MIRT615243)
- hsa-mir-3074-5p (MIRT615244)
- hsa-mir-6893-3p (MIRT615245)
- hsa-mir-370-3p (MIRT615246)
- hsa-mir-1238-3p (MIRT708549)
- hsa-mir-670-3p (MIRT708550)
- hsa-mir-3620-5p (MIRT708551)
- hsa-mir-1587 (MIRT708552)
- hsa-mir-4674 (MIRT708553)
- hsa-mir-6870-3p (MIRT708554)
- hsa-mir-660-3p (MIRT708555)
- hsa-mir-5193 (MIRT708556)
- hsa-mir-6891-3p (MIRT708557)
- hsa-mir-6072 (MIRT708558)
- hsa-mir-4793-5p (MIRT708559)
- hsa-mir-5196-3p (MIRT708560)
- hsa-mir-548s (MIRT720632)
- hsa-mir-3926 (MIRT720633)
- hsa-mir-5003-3p (MIRT720634)
- hsa-mir-3190-5p (MIRT720635)
miRNA Products
- Search ViGene Biosciences for SPA17
Inhibitory RNA Products
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- Overview of 85 available SPA17 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for SPA17 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SPA17
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SPA17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPA17
-
ViGene Biosciences adenoviral particle packaged cDNA for SPA17 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPA17 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPA17 Gene
Localization for SPA17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPA17 Gene
- Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| cytosol | 3 |
| nucleus | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 18421703 |
| GO:0005929 | cilium | IDA,IEA | 18421703 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031514 | motile cilium | IDA | 18421703 |
Pathways & Interactions for SPA17 Gene
No Data Available
Interacting Proteins for SPA17 Gene
Selected Interacting proteins:
Q15506-SP17_HUMAN
ENSP00000227135
for SPA17 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003351 | epithelial cilium movement | NAS | 18421703 |
| GO:0007283 | spermatogenesis | TAS | 8688458 |
| GO:0007338 | single fertilization | TAS | 8688458 |
| GO:0007339 | binding of sperm to zona pellucida | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPA17 Gene
Transcripts for SPA17 Gene
mRNA/cDNA for SPA17 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (82) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPA17 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPA17
- genomics-online: gRNA clones - Search results for 85 available SPA17 gene related products
- Overview of 85 available SPA17 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPA17
- GenScript: Design CRISPR guide RNA sequences for SPA17
miRNA Products
- Search ViGene Biosciences for SPA17
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPA17
- Browse OriGene Inhibitory RNA Products For SPA17
- genomics-online: shRNA clones - Search results for 85 available SPA17 gene related products
- Overview of 85 available SPA17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPA17 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SPA17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPA17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SPA17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SPA17 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Testis Interstitium
- Seminiferous Tubules
- XY Germ Cells Testis Cord
- Leydig Cells Testis Interstitium
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Gonad
- XY Germ Cells Testis Cord
mRNA differential expression in normal tissues according to GTEx for SPA17 Gene
This gene is overexpressed in Testis (x22.0).
This gene is overexpressed in Ovary (53.6) and Testis (13.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPA17 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SPA17 Gene:
SPA17SOURCE GeneReport for Unigene cluster for SPA17 Gene:
Hs.286233mRNA Expression by UniProt/SwissProt for SPA17 Gene:
Q15506-SP17_HUMAN
Tissue specificity:
Testis and sperm specific.
Evidence on tissue expression from TISSUES for SPA17 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for SPA17
-
OriGene qPCR primer pairs and template standards for SPA17
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPA17 Gene
Orthologs for SPA17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPA17 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SPA17 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SPA17 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Spa17 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Spa17 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPA17 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SPA17 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SPA17 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | spa17 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | spa17 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | F39H12.3 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for SPA17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SPA17 Gene
Pseudogenes.org Pseudogenes for SPA17 Gene
No data available for Paralogs for SPA17 Gene
Variants for SPA17 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000162551 | -- | 124,683,734(+) | C/A | intron_variant | |
| rs1000215927 | -- | 124,675,064(+) | T/G | intron_variant | |
| rs1000272722 | -- | 124,674,841(+) | A/T | intron_variant | |
| rs1000297954 | -- | 124,683,468(+) | A/G | intron_variant | |
| rs1000318835 | -- | 124,688,662(+) | A/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1045156 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.98;
20.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPA17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPA17
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPA17 Gene
Disorders for SPA17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian cancer |
|
Search SPA17 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPA17
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SPA17 Gene
Publications for SPA17 Gene
- Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. (PMID: 8688458) Lea IA … O'Rand MG (Biochimica et biophysica acta 1996) 2 3 4 22 58
- A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies. (PMID: 17551920) Li Z … Lim SH (International journal of cancer 2007) 3 4 22 58
- Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. (PMID: 12393185) Buchli R … Robbins DL (Biochimica et biophysica acta 2002) 3 4 22 58
- Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. (PMID: 19685492) Kausar T … Ralhan R (International journal of cancer 2010) 3 22 58
- Sperm protein 17 is expressed in the sperm fibrous sheath. (PMID: 19604394) Chiriva-Internati M … Kast WM (Journal of translational medicine 2009) 3 22 58
Products for SPA17 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for SPA17
- VectorBuilder custom plasmid, inducible vectors for SPA17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPA17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 57 available SPA17 Antibodies ranked by validation data
- Compare Top SPA17 Antibodies
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- GeneTex SPA17 antibody for SPA17
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- ViGene Biosciences adenoviral particle packaged cDNA for SPA17 gene
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- genomics-online: cdna clones - Search results for 85 available SPA17 gene related products
- Overview of 85 available SPA17 gene related products
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- Overview of 85 available SPA17 gene related products
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- Overview of 85 available SPA17 gene related products
Sources for SPA17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
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