Aliases for SPA17 Gene
External Ids for SPA17 Gene
Previous GeneCards Identifiers for SPA17 Gene
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
GeneCards Summary for SPA17 Gene
SPA17 (Sperm Autoantigenic Protein 17) is a Protein Coding gene. Diseases associated with SPA17 include Ovarian Cancer and Pelvic Varices. Gene Ontology (GO) annotations related to this gene include calmodulin binding. An important paralog of this gene is GAP43.
UniProtKB/Swiss-Prot Summary for SPA17 Gene
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).