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This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
SPA17 (Sperm Autoantigenic Protein 17) is a Protein Coding gene. Diseases associated with SPA17 include Ovarian Cancer and Pelvic Varices. Gene Ontology (GO) annotations related to this gene include calmodulin binding. An important paralog of this gene is GAP43.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15257753 |
GO:0005516 | calmodulin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 18421703 |
GO:0005929 | cilium | IDA | 18421703 |
GO:0009897 | external side of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003351 | epithelial cilium movement | NAS | 18421703 |
GO:0007283 | spermatogenesis | TAS | 8688458 |
GO:0007338 | single fertilization | TAS | 8688458 |
GO:0007339 | binding of sperm to zona pellucida | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SPA17 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SPA17 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SPA17 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Spa17 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Spa17 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SPA17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SPA17 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SPA17 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | spa17 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | spa17 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | F39H12.3 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1045156 | CNV | loss | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|
|
pelvic varices |
|
|
male infertility |
|
|